scholarly journals Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis

2018 ◽  
Vol 110 (9) ◽  
pp. 1035-1038 ◽  
Author(s):  
James Yarmolinsky ◽  
Carolina Bonilla ◽  
Philip C Haycock ◽  
Ryan J Q Langdon ◽  
Luca A Lotta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

Abstract 1270: Vitamin E related genetic variants and prostate cancer risk: A Mendelian randomization analysis

2017 ◽  
Author(s):  
Tracy M. Layne ◽  
Shakira M. Nelson ◽  
Stephanie J. Weinstein ◽  
Eric Karlins ◽  
Stephen J. Chanock ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin E ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

2017 ◽  
Author(s):  
James Yarmolinsky ◽  
Carolina Bonilla ◽  
Philip C Haycock ◽  
Ryan JQ Langdon ◽  
Luca A Lotta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Type 2 Diabetes ◽  
Cancer Risk ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk ◽  
Selenium Supplementation ◽  
High Grade ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

AbstractIn the Selenium and Vitamin E Cancer Prevention Trial (SELECT), selenium supplementation (causing a median 114 μg/L increase in circulating selenium) did not lower overall prostate cancer risk, but increased risk of high-grade prostate cancer and type 2 diabetes. Mendelian randomization analysis uses genetic variants to proxy modifiable risk factors and can strengthen causal inference in observational studies. We constructed a genetic risk score comprising eleven single-nucleotide polymorphisms robustly (P<5x10−8) associated with circulating selenium in genome-wide association studies. In a Mendelian randomization analysis of 72,729 men in the PRACTICAL Consortium (44,825 cases, 27,904 controls), 114 μg/L higher genetically-elevated circulating selenium was not associated with prostate cancer (OR: 1.01; 95% CI: 0.89-1.13). Concordant with findings from SELECT, selenium was weakly associated with advanced (including high-grade) prostate cancer (OR: 1.21; 95% CI: 0.98-1.49) and type 2 diabetes (OR: 1.18; 95% CI: 0.97-1.43; in a type 2 diabetes GWAS meta-analysis with up to 49,266 cases, 249,906 controls). Mendelian randomization mirrored the outcome of selenium supplementation in SELECT and may offer an approach for the prioritization of interventions for follow-up in large-scale randomized controlled trials.

scholarly journals Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis

2016 ◽  
Vol 140 (2) ◽  
pp. 322-328 ◽  
Author(s):  
Amy E. Taylor ◽  
Richard M. Martin ◽  
Milan S. Geybels ◽  
Janet L. Stanford ◽  
Irene Shui ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk ◽  
Coffee Consumption ◽  
Causal Role ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Depression and prostate cancer risk: A Mendelian randomization study

2020 ◽  
Vol 9 (23) ◽  
pp. 9160-9167
Author(s):  
Xiong Chen ◽  
Jianqiu Kong ◽  
Xiayao Diao ◽  
Jiahao Cai ◽  
Junjiong Zheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk

scholarly journals 237P Breast cancer risk in patients with polycystic ovary syndrome: A Mendelian randomization analysis

2020 ◽  
Vol 31 ◽  
pp. S335
Author(s):  
X. Wu ◽  
Y. Wen ◽  
H. Peng ◽  
C. Li ◽  
H. Liang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Polycystic Ovary Syndrome ◽  
Mendelian Randomization ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Appraising the role of previously reported risk factors in epithelial ovarian cancer risk: A Mendelian randomization analysis

PLoS Medicine ◽  
2019 ◽  
Vol 16 (8) ◽  
pp. e1002893 ◽  
Author(s):  
James Yarmolinsky ◽  
Caroline L. Relton ◽  
Artitaya Lophatananon ◽  
Kenneth Muir ◽  
Usha Menon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ovarian Cancer ◽  
Cancer Risk ◽  
Epithelial Ovarian Cancer ◽  
Mendelian Randomization ◽  
Ovarian Cancer Risk ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Appraising causal relationships of dietary, nutritional and physical-activity exposures with overall and aggressive prostate cancer: two-sample Mendelian-randomization study based on 79 148 prostate-cancer cases and 61 106 controls

2019 ◽  
Vol 49 (2) ◽  
pp. 587-596 ◽  
Author(s):  
Nabila Kazmi ◽  
Philip Haycock ◽  
Konstantinos Tsilidis ◽  
Brigid M Lynch ◽  
Therese Truong ◽  
...  
Keyword(s):  
Physical Activity ◽  
Prostate Cancer ◽  
Risk Factors ◽  
Cancer Risk ◽  
Serum Iron ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk ◽  
Uk Biobank ◽  
Monounsaturated Fat ◽  
Aggressive Prostate Cancer

Abstract Background Prostate cancer is the second most common male cancer worldwide, but there is substantial geographical variation, suggesting a potential role for modifiable risk factors in prostate carcinogenesis. Methods We identified previously reported prostate cancer risk factors from the World Cancer Research Fund (WCRF)’s systematic appraisal of the global evidence (2018). We assessed whether each identified risk factor was causally associated with risk of overall (79 148 cases and 61 106 controls) or aggressive (15 167 cases and 58 308 controls) prostate cancer using Mendelian randomization (MR) based on genome-wide association-study summary statistics from the PRACTICAL and GAME-ON/ELLIPSE consortia. We assessed evidence for replication in UK Biobank (7844 prostate-cancer cases and 204 001 controls). Results WCRF identified 57 potential risk factors, of which 22 could be instrumented for MR analyses using single nucleotide polymorphisms. For overall prostate cancer, we identified evidence compatible with causality for the following risk factors (odds ratio [OR] per standard deviation increase; 95% confidence interval): accelerometer-measured physical activity, OR = 0.49 (0.33–0.72; P = 0.0003); serum iron, OR = 0.92 (0.86–0.98; P = 0.007); body mass index (BMI), OR = 0.90 (0.84–0.97; P = 0.003); and monounsaturated fat, OR = 1.11 (1.02–1.20; P = 0.02). Findings in our replication analyses in UK Biobank were compatible with our main analyses (albeit with wide confidence intervals). In MR analysis, height was positively associated with aggressive-prostate-cancer risk: OR = 1.07 (1.01–1.15; P = 0.03). Conclusions The results for physical activity, serum iron, BMI, monounsaturated fat and height are compatible with causality for prostate cancer. The results suggest that interventions aimed at increasing physical activity may reduce prostate-cancer risk, although interventions to change other risk factors may have negative consequences on other diseases.

scholarly journals Blood lipids and prostate cancer: a Mendelian randomization analysis

2016 ◽  
Vol 5 (6) ◽  
pp. 1125-1136 ◽  
Author(s):  
Caroline J. Bull ◽  
Carolina Bonilla ◽  
Jeff M. P. Holly ◽  
Claire M. Perks ◽  
Neil Davies ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Blood Lipids ◽  
Mendelian Randomization ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis
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