Age-Related Changes in the Concentration of Cytosolic Androgen Receptors in the Epididymis, Vas Deferens and Seminal Vesicle of Maturing Male Mice

1989 ◽  
Vol 10 (3) ◽  
pp. 188-194 ◽  
Author(s):  
G. VEYSSIERE ◽  
M. BERGER ◽  
M. De TURCKHEIM

Gerontology ◽  
1988 ◽  
Vol 34 (3) ◽  
pp. 128-133 ◽  
Author(s):  
Kishio Ono ◽  
Masafumi Haji ◽  
Hajime Nawata ◽  
Toshio Maki ◽  
Ken-ichi Kato ◽  
...  


Author(s):  
Ika Fidianingsih ◽  
Dwi Nur Ahsani

Introduction<br />Aging is characterized by gradual impairment in all physiological functions. Increases in free radicals and changes in organ morphology occur with aging. The purpose of this study was to determine age-related changes in serum free radicals, body weight, organ weights, and relative organ weights in male mice. <br /><br />Methods<br />An experimental animal study was performed on 25 male mice (Mus musculus), which were randomized into 5 groups according to age at termination, i.e. 12 (group K1), 24 (K2), 32 (K3), 40 (K4) and 48 weeks (K5), respectively. Retro-orbital venous blood was taken for examination of malondialdehyde (MDA) levels. After termination, liver, heart, kidneys, testes, brain, thymus and spleen were weighed using an analytical balance. ANOVA and Kruskal Wallis tests were used to analyze the data, with p&lt;0.05 being considered significant. <br /><br />Results<br />Significant changes were found with age in serum MDA level (p=0.000), body weight (p=0.000), and weights of all organs except thymus (p&gt;0.05) (liver p=0.023, heart p=0.000, kidneys p=0.002, testes p=0.000, brain p=0.012 and spleen p=0.006). Significant changes in relative weight of brain (p=0.001) and spleen (p=0.049) were also found with age. <br /><br />Conclusion<br />This study demonstrated increases in serum MDA levels, body weight, and weights of the liver, heart, kidneys, testes, brain and spleen with age. Peak increases in weights of kidneys and thymus were found earlier than those in MDA levels and weights of other organs.



2004 ◽  
Vol 24 (1-2) ◽  
pp. 53-66 ◽  
Author(s):  
Makoto Yono ◽  
Jamshid Latifpour ◽  
Wataru Takahashi ◽  
Mehdi Pouresmail ◽  
Parviz Afiatpour ◽  
...  




1995 ◽  
Vol 82 (1) ◽  
pp. 19-29 ◽  
Author(s):  
G. Sánchez-Visconti ◽  
L. Herrero ◽  
M. Rabadán ◽  
I. Pereira ◽  
A. Ruiz-Torres


2004 ◽  
Vol 998 (2) ◽  
pp. 164-173 ◽  
Author(s):  
Sachi Kuwahara ◽  
Dwi Kesuma Sari ◽  
Yasuhiro Tsukamoto ◽  
Shin Tanaka ◽  
Fumihiko Sasaki


2012 ◽  
Vol 295 (5) ◽  
pp. 886-895 ◽  
Author(s):  
Eduardo M. Chaves ◽  
Claudia Aguilera-Merlo ◽  
Albana Cruceño ◽  
Teresa Fogal ◽  
Ramón Piezzi ◽  
...  


1984 ◽  
Vol 102 (1) ◽  
pp. 103-107 ◽  
Author(s):  
Ch. Jean-Faucher ◽  
M. Berger ◽  
M. De Turckheim ◽  
G. Veyssiere ◽  
Cl. Jean

ABSTRACT Cyproterone acetate was administered every 2 days from 1 to 39 days of age to male mice which were killed 24 h or 20 days after the last injection. Cyproterone acetate caused a significant reduction in the relative weights of the epididymis, vas deferens, seminal vesicle and preputial gland, which was still evident at 60 days after birth. Testicular and epididymal androgens (testosterone and dihydrotestosterone) and circulating LH and FSH concentrations were equal to or higher than those of controls at 60 days. Cyproterone acetate did not inhibit spermatogenesis but all males were infertile. The results suggest that the peripheral effects of testosterone are necessary, during early stages of sexual maturation, in order to obtain subsequent full development of the accessory sex organs. J. Endocr. (1984) 102, 103–107





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