Regional gene therapy for bone healing using a 3D printed scaffold in a rat femoral defect model

2021 ◽  
Author(s):  
H Paco Kang ◽  
Hansel Ihn ◽  
Djani M Robertson ◽  
Xiao Chen ◽  
Osamu Sugiyama ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bone Healing ◽  
Defect Model ◽  
Femoral Defect ◽  
3D Printed ◽  
Regional Gene

scholarly journals 3D printed hyperelastic “bone” scaffolds and regional gene therapy: A novel approach to bone healing

2018 ◽  
Vol 106 (4) ◽  
pp. 1104-1110 ◽  
Author(s):  
Ram Alluri ◽  
Adam Jakus ◽  
Sofia Bougioukli ◽  
William Pannell ◽  
Osamu Sugiyama ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bone Healing ◽  
Bone Scaffolds ◽  
Novel Approach ◽  
3D Printed ◽  
Regional Gene

scholarly journals Regional gene therapy with 3D printed scaffolds to heal critical sized bone defects in a rat model

2019 ◽  
Vol 107 (10) ◽  
pp. 2174-2182 ◽  
Author(s):  
Ram Alluri ◽  
Xuan Song ◽  
Sofia Bougioukli ◽  
William Pannell ◽  
Venus Vakhshori ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Rat Model ◽  
Bone Defects ◽  
3D Printed ◽  
Regional Gene

scholarly journals Topical cutaneous application of CO2 accelerates bone healing in a rat femoral defect model

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Yu Kuroiwa ◽  
Tomoaki Fukui ◽  
Shunsuke Takahara ◽  
Sang Yang Lee ◽  
Keisuke Oe ◽  
...  
Keyword(s):  
Bone Healing ◽  
Defect Model ◽  
Femoral Defect ◽  
Cutaneous Application

scholarly journals Serum albumin enhances bone healing in a nonunion femoral defect model in rats: a computer tomography micromorphometry study

2013 ◽  
Vol 37 (4) ◽  
pp. 741-745 ◽  
Author(s):  
Gábor Skaliczki ◽  
Károly Schandl ◽  
Miklós Weszl ◽  
Tibor Major ◽  
Miklós Kovács ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Computer Tomography ◽  
Bone Healing ◽  
Defect Model ◽  
Femoral Defect

Compromised bone healing following spacer removal in a rat femoral defect model

2012 ◽  
Vol 99 (2) ◽  
pp. 223-232 ◽  
Author(s):  
Gábor Skaliczki ◽  
M. Weszl ◽  
K. Schandl ◽  
T. Major ◽  
M. Kovács ◽  
...  
Keyword(s):  
Bone Healing ◽  
Defect Model ◽  
Femoral Defect

scholarly journals Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Ariane Zamarioli ◽  
Zachery R. Campbell ◽  
Kevin A. Maupin ◽  
Paul J. Childress ◽  
Joao P. B. Ximenez ◽  
...  
Keyword(s):  
Bone Loss ◽  
Mechanical Loading ◽  
Bone Healing ◽  
Space Flight ◽  
Bone Fracture ◽  
Local Administration ◽  
Systemic Effects ◽  
Human Presence ◽  
Femoral Defect ◽  
Healing Agent

AbstractWith increased human presence in space, bone loss and fractures will occur. Thrombopoietin (TPO) is a recently patented bone healing agent. Here, we investigated the systemic effects of TPO on mice subjected to spaceflight and sustaining a bone fracture. Forty, 9-week-old, male, C57BL/6 J were divided into 4 groups: (1) Saline+Earth; (2) TPO + Earth; (3) Saline+Flight; and (4) TPO + Flight (n = 10/group). Saline- and TPO-treated mice underwent a femoral defect surgery, and 20 mice were housed in space (“Flight”) and 20 mice on Earth for approximately 4 weeks. With the exception of the calvarium and incisor, positive changes were observed in TPO-treated, spaceflight bones, suggesting TPO may improve osteogenesis in the absence of mechanical loading. Thus, TPO, may serve as a new bone healing agent, and may also improve some skeletal properties of astronauts, which might be extrapolated for patients on Earth with restraint mobilization and/or are incapable of bearing weight on their bones.

scholarly journals Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xinchen Du ◽  
Le Wu ◽  
Hongyu Yan ◽  
Zhuyan Jiang ◽  
Shilin Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Shape Recovery ◽  
Parenchymal Cell ◽  
Gelatin Sponge ◽  
Defect Model ◽  
Liver Parenchymal Cell ◽  
E Coli ◽  
Tissue Integration ◽  
3D Printed

AbstractDeveloping an anti-infective shape-memory hemostatic sponge able to guide in situ tissue regeneration for noncompressible hemorrhages in civilian and battlefield settings remains a challenge. Here we engineer hemostatic chitosan sponges with highly interconnective microchannels by combining 3D printed microfiber leaching, freeze-drying, and superficial active modification. We demonstrate that the microchannelled alkylated chitosan sponge (MACS) exhibits the capacity for water and blood absorption, as well as rapid shape recovery. We show that compared to clinically used gauze, gelatin sponge, CELOX™, and CELOX™-gauze, the MACS provides higher pro-coagulant and hemostatic capacities in lethally normal and heparinized rat and pig liver perforation wound models. We demonstrate its anti-infective activity against S. aureus and E. coli and its promotion of liver parenchymal cell infiltration, vascularization, and tissue integration in a rat liver defect model. Overall, the MACS demonstrates promising clinical translational potential in treating lethal noncompressible hemorrhage and facilitating wound healing.

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