New approach for vertical bone regeneration usingin situgelling and sustained BMP-2 releasing poly(phosphazene) hydrogel system on peri-implant site with critical defect in a canine model

2017 ◽  
Vol 106 (2) ◽  
pp. 751-759 ◽  
Author(s):  
Bo-Bae Seo ◽  
Hae-Im Chang ◽  
Hyuck Choi ◽  
Jeong-Tae Koh ◽  
Kwi-Dug Yun ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Canine Model ◽  
New Approach ◽  
Critical Defect ◽  
Hydrogel System

scholarly journals Alginate-nanohydroxyapatite hydrogel system: Optimizing the formulation for enhanced bone regeneration

2019 ◽  
Vol 105 ◽  
pp. 109985 ◽  
Author(s):  
J. Barros ◽  
M.P. Ferraz ◽  
J. Azeredo ◽  
M.H. Fernandes ◽  
P.S. Gomes ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Hydrogel System

Guided Bone Engineering: Healing of Large Bone Defects

2006 ◽  
Vol 49 ◽  
pp. 181-188
Author(s):  
Jan Schrooten ◽  
Tim Van Cleynenbreugel ◽  
Saartje Impens ◽  
Jan Luyten ◽  
Astrid Bakker ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Animal Experiments ◽  
3D Scaffold ◽  
Cell Behaviour ◽  
New Approach ◽  
Bearing Defects ◽  
Quantitative Screening ◽  
Large Bone ◽  
Large Bone Defects

Tissue engineering (TE) aims/seeks to achieve the substitution of organ transplantation by the creation of living, functional tissues. It has been suggested that biocompatible porous materials (scaffolds) and a controllable 3D environment are required to aid in the 3D cell organisation and their development into functional tissue. Our research envisions a TE-approach towards the repair of large, load bearing defects in long bones. In vitro standardised, systematic, quantitative screening of potential bone scaffolds is required to understand how scaffolds can affect cell behaviour. This screening will avoid a trial-and-error approach and thus limit the number of animal experiments. Such a screening should be based on the knowledge of mechanical, physical and (bio)chemical scaffold properties and their interaction with cell behaviour. In addition, the design and production of a clinically relevant scaffold requires control over its mechanical behaviour and a new approach for cell seeding in a 3D scaffold, as well as providing nutrition for the engrafted cells. The objective of this research is to gain substantial knowledge about guided bone regeneration and to develop quantitative methodologies that can lead to consistent and reproducible bone regeneration.

Valproic Acid Prevents Brain Injury in a Canine Model of Hypothermic Circulatory Arrest: A Promising New Approach to Neuroprotection During Cardiac Surgery

2006 ◽  
Vol 81 (6) ◽  
pp. 2235-2242 ◽  
Author(s):  
Jason A. Williams ◽  
Christopher J. Barreiro ◽  
Lois U. Nwakanma ◽  
Mary S. Lange ◽  
Lisa E. Kratz ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Cardiac Surgery ◽  
Brain Injury ◽  
Circulatory Arrest ◽  
Canine Model ◽  
Hypothermic Circulatory Arrest ◽  
New Approach

Shell Scaffolds: A new approach towards high strength bioceramic scaffolds for bone regeneration

2010 ◽  
Vol 64 (2) ◽  
pp. 203-206 ◽  
Author(s):  
Devis Bellucci ◽  
Valeria Cannillo ◽  
Antonella Sola
Keyword(s):  
Bone Regeneration ◽  
High Strength ◽  
New Approach

scholarly journals Fabrication of silver nanoparticles/gelatin hydrogel system for bone regeneration and fracture treatment

Drug Delivery ◽  
2021 ◽  
Vol 28 (1) ◽  
pp. 319-324
Author(s):  
Xingwen Han ◽  
Jingjing He ◽  
Zhan Wang ◽  
Zhongtian Bai ◽  
Peng Qu ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Bone Regeneration ◽  
Fracture Treatment ◽  
Gelatin Hydrogel ◽  
Hydrogel System

scholarly journals PRGF-Modified Collagen Membranes for Guided Bone Regeneration: Spectroscopic, Microscopic and Nano-Mechanical Investigations

2019 ◽  
Vol 9 (5) ◽  
pp. 1035 ◽  
Author(s):  
Cristian Ratiu ◽  
Marcel Brocks ◽  
Traian Costea ◽  
Liviu Moldovan ◽  
Simona Cavalu
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Enzymatic Degradation ◽  
Young Modulus ◽  
Guided Bone Regeneration ◽  
Fiber Density ◽  
New Approach ◽  
Before And After ◽  
Collagen Membranes ◽  
Membrane Type

The aim of our study was to evaluate the properties of different commercially available resorbable collagen membranes for guided bone regeneration, upon addition of plasma rich in growth factors (PRGF). The structural and morphological details, mechanical properties, and enzymatic degradation were investigated in a new approach, providing clinicians with new data in order to help them in a successful comparison and better selection of membranes with respect to their placement and working condition. Particular characteristics such as porosity, fiber density, and surface topography may influence the mechanical behavior and performances of the membranes, as revealed by SEM/AFM and nanoindentation measurements. The mechanical properties and enzymatic degradation of the membranes were analyzed in a comparative manner, before and after PRGF-modification. The changes in Young modulus values are correlated with the ultrastructural properties of each membrane type. The enzymatic (trypsin) degradation test also emphasized that PRGF-modified membranes exhibit a slower degradation compared to the native ones.

Synthesis and characterization of a novel injectable alginate–collagen–hydroxyapatite hydrogel for bone tissue regeneration

2015 ◽  
Vol 3 (15) ◽  
pp. 3081-3090 ◽  
Author(s):  
Stephanie T. Bendtsen ◽  
Mei Wei
Keyword(s):  
Bone Regeneration ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Gelation Time ◽  
Bone Tissue Regeneration ◽  
Synthesis And Characterization ◽  
Injectable Hydrogel ◽  
Surgical Setting ◽  
Hydrogel System

This novel fabrication process allowed for the development of an injectable hydrogel system with a gelation time suitable for a surgical setting and components necessary for promoting enhanced bone regeneration.

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