PLK2 protects retinal ganglion cells from oxidative stress by potentiating Nrf2 signaling via GSK‐3β

2021 ◽  
Author(s):  
Yazhi Fan ◽  
Jianming Wang ◽  
Na He ◽  
Haixiao Feng
Keyword(s):  
Oxidative Stress ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Gsk 3Β

Renin–angiotensin system involvement in the oxidative stress-induced neurodegeneration of cultured retinal ganglion cells

2012 ◽  
Vol 57 (1) ◽  
pp. 126-132 ◽  
Author(s):  
Yoko Ozawa ◽  
Kenya Yuki ◽  
Reiko Yamagishi ◽  
Kazuo Tsubota ◽  
Makoto Aihara
Keyword(s):  
Oxidative Stress ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Renin Angiotensin System ◽  
Retinal Ganglion ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
System Involvement

The Effects of Oxidative Stress on Mitochondrial Transmembrane Potential in Retinal Ganglion Cells

2003 ◽  
Vol 5 (5) ◽  
pp. 641-646 ◽  
Author(s):  
Christopher J. Lieven ◽  
Joshua P. Vrabec ◽  
Leonard A. Levin
Keyword(s):  
Oxidative Stress ◽  
Retinal Ganglion Cells ◽  
Transmembrane Potential ◽  
Ganglion Cells ◽  
Mitochondrial Transmembrane Potential ◽  
Retinal Ganglion

The Extract of Chlorella vulgaris Protects Transformed Retinal Ganglion Cells from Oxidative Stress-induced Cells Death

2013 ◽  
Vol 38 (2) ◽  
pp. 129-139 ◽  
Author(s):  
Kyung-A Kim ◽  
Kwang Hyun Cha ◽  
Soon-Jung Choi ◽  
Cheol-Ho Pan ◽  
Sang Hoon Jung
Keyword(s):  
Oxidative Stress ◽  
Retinal Ganglion Cells ◽  
Chlorella Vulgaris ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Cells Death

scholarly journals Expression of the cystine-glutamate exchanger (xc −) in retinal ganglion cells and regulation by nitric oxide and oxidative stress

2006 ◽  
Vol 324 (2) ◽  
pp. 189-202 ◽  
Author(s):  
Y. Dun ◽  
B. Mysona ◽  
T. Van Ells ◽  
L. Amarnath ◽  
M. Shamsul Ola ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
And Oxidative Stress

scholarly journals Down-regulated LAMA4 inhibits oxidative stress-induced apoptosis of retinal ganglion cells through the MAPK signaling pathway in rats with glaucoma

Cell Cycle ◽  
2019 ◽  
Vol 18 (9) ◽  
pp. 932-948 ◽  
Author(s):  
Chong Wang ◽  
Ya-Lin Ren ◽  
Jin Zhai ◽  
Xiao-Yan Zhou ◽  
Jing Wu
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Retinal Ganglion ◽  
Induced Apoptosis

scholarly journals Brazilian Green Propolis Protects against Retinal Damage In Vitro and In Vivo

2006 ◽  
Vol 3 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Yuta Inokuchi ◽  
Masamitsu Shimazawa ◽  
Yoshimi Nakajima ◽  
Shinsuke Suemori ◽  
Satoshi Mishima ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Water Soluble ◽  
Retinal Damage ◽  
Retinal Ganglion ◽  
Neuroprotective Effects ◽  
Brazilian Green Propolis

Propolis, a honeybee product, has gained popularity as a food and alternative medicine. Its constituents have been shown to exert pharmacological (anticancer, antimicrobial and anti-inflammatory) effects. We investigated whether Brazilian green propolis exerts neuroprotective effects in the retinain vitroand/orin vivo.In vitro, retinal damage was induced by 24 h hydrogen peroxide (H2O2) exposure, and cell viability was measured by Hoechst 33342 and YO-PRO-1 staining or by a resazurin–reduction assay. Propolis inhibited the neurotoxicity and apoptosis induced in cultured retinal ganglion cells (RGC-5, a rat ganglion cell line transformed using E1A virus) by 24 h H2O2 exposure. Propolis also inhibited the neurotoxicity induced in RGC-5 cultures by staurosporine. Regarding the possible underlying mechanism, in pig retina homogenates propolis protected against oxidative stress (lipid peroxidation), as also did trolox (water-soluble vitamin E). In micein vivo, propolis (100 mg kg−1; intraperitoneally administered four times) reduced the retinal damage (decrease in retinal ganglion cells and in thickness of inner plexiform layer) induced by intravitrealin vivo N-methyl-d-aspartate injection. These findings indicate that Brazilian green propolis has neuroprotective effects against retinal damage bothin vitroandin vivo, and that a propolis-induced inhibition of oxidative stress may be partly responsible for these neuroprotective effects.

The compound isolated from the leaves of Phyllostachys nigra protects oxidative stress-induced retinal ganglion cells death

2010 ◽  
Vol 48 (6) ◽  
pp. 1721-1727 ◽  
Author(s):  
Hee Ju Lee ◽  
Kyung-A Kim ◽  
Kui Dong Kang ◽  
Eun Ha Lee ◽  
Chul Young Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Phyllostachys Nigra ◽  
Cells Death
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