MicroRNA-19b Reduces Hepatic Stellate Cell Proliferation by Targeting GRB2 in Hepatic Fibrosis Models In Vivo and In Vitro as Part of the Inhibitory Effect of Estradiol

2015 ◽  
Vol 116 (11) ◽  
pp. 2455-2464 ◽  
Author(s):  
Shanfei Ge ◽  
Jianping Xie ◽  
Fei Liu ◽  
Jinni He ◽  
Jinwen He
Keyword(s):  
Cell Proliferation ◽  
Hepatic Fibrosis ◽  
Hepatic Stellate Cell ◽  
Stellate Cell ◽  
Inhibitory Effect

Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis

1999 ◽  
Vol 117 (5) ◽  
pp. 1198-1204 ◽  
Author(s):  
Jianliang Zhu ◽  
Jian Wu ◽  
Edward Frizell ◽  
Shu-Ling Liu ◽  
Reza Bashey ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Stellate Cell ◽  
In Vivo Model ◽  
Proliferation In Vitro

CAT1 silencing inhibits TGF-β1-induced mouse hepatic stellate cell activation in vitro and hepatic fibrosis in vivo

Cytokine ◽  
2020 ◽  
Vol 136 ◽  
pp. 155288
Author(s):  
Feng Peng ◽  
Yi Tian ◽  
Jing Ma ◽  
Zhenyu Xu ◽  
Sujuan Wang ◽  
...  
Keyword(s):  
Hepatic Fibrosis ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Hepatic Stellate Cell Activation ◽  
Tgf Β1

scholarly journals Inhibitory effect of oestradiol on activation of rat hepatic stellate cells in vivo and in vitro

Gut ◽  
1999 ◽  
Vol 44 (1) ◽  
pp. 127-136 ◽  
Author(s):  
I Shimizu ◽  
Y Mizobuchi ◽  
M Yasuda ◽  
M Shiba ◽  
Y-R Ma ◽  
...  
Keyword(s):  
Hepatic Fibrosis ◽  
Hepatic Stellate Cells ◽  
Stellate Cell ◽  
Stellate Cells ◽  
Inhibitory Effect ◽  
Type I ◽  
Mrna Levels ◽  
Pig Serum

BackgroundHepatic stellate cells play a key role in the pathogenesis of hepatic fibrosis.AimsTo examine the inhibitory effect of oestradiol on stellate cell activation.MethodsIn vivo, hepatic fibrosis was induced in rats by dimethylnitrosamine or pig serum. In vitro, rat stellate cells were activated by contact with plastic dishes resulting in their transformation into myofibroblast-like cells.ResultsIn the dimethylnitrosamine and pig serum models, treatment with oestradiol at gestation related doses resulted in a dose dependent suppression of hepatic fibrosis with restored content of hepatic retinyl palmitate, reduced collagen content, lower areas of stellate cells which express α smooth muscle actin (α-SMA) and desmin, and lower procollagen type I and III mRNA levels in the liver. In cultured stellate cells, oestradiol inhibited type I collagen production, α-SMA expression, and cell proliferation. These findings suggest that oestradiol is a potent inhibitor of stellate cell transformation.ConclusionThe antifibrogenic role of oestradiol in the liver may contribute to the sex associated differences in the progression from hepatic fibrosis to cirrhosis.

Fungus thielavia minor blocks hepatic stellate cell proliferation and inhibits experemental hepatic fibrosis in rats

1998 ◽  
Vol 114 ◽  
pp. A1348
Author(s):  
H. Sugawara ◽  
T. Ueno ◽  
S. Tamaki ◽  
M. Sakamoto ◽  
T. Torimura ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Hepatic Fibrosis ◽  
Hepatic Stellate Cell ◽  
Stellate Cell
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