Anacardic Acid, Salicylic Acid, and Oleic Acid Differentially Alter Cellular Bioenergetic Function in Breast Cancer Cells

2016 ◽  
Vol 117 (11) ◽  
pp. 2521-2532 ◽  
Author(s):  
Brandie N. Radde ◽  
Negin Alizadeh-Rad ◽  
Stephanie M. Price ◽  
David J. Schultz ◽  
Carolyn M. Klinge
Keyword(s):  
Breast Cancer ◽  
Salicylic Acid ◽  
Oleic Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Anacardic Acid

scholarly journals Transcriptomic response of breast cancer cells to anacardic acid

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
David J. Schultz ◽  
Abirami Krishna ◽  
Stephany L. Vittitow ◽  
Negin Alizadeh-Rad ◽  
Penn Muluhngwi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Anacardic Acid ◽  
Transcriptomic Response

Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells

2013 ◽  
Vol 88 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Adriana Soto-Guzman ◽  
Socrates Villegas-Comonfort ◽  
Pedro Cortes-Reynosa ◽  
Eduardo Perez Salazar
Keyword(s):  
Breast Cancer ◽  
Arachidonic Acid ◽  
Oleic Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Acid Metabolism ◽  
Arachidonic Acid Metabolism

Oleic acid promotes migration on MDA-MB-231 breast cancer cells through an arachidonic acid-dependent pathway

2010 ◽  
Vol 42 (2) ◽  
pp. 306-317 ◽  
Author(s):  
Napoleon Navarro-Tito ◽  
Adriana Soto-Guzman ◽  
Luis Castro-Sanchez ◽  
Raul Martinez-Orozco ◽  
Eduardo Perez Salazar
Keyword(s):  
Breast Cancer ◽  
Arachidonic Acid ◽  
Oleic Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Dependent Pathway

scholarly journals Genome-wide miRNA response to anacardic acid in breast cancer cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184471 ◽  
Author(s):  
David J. Schultz ◽  
Penn Muluhngwi ◽  
Negin Alizadeh-Rad ◽  
Madelyn A. Green ◽  
Eric C. Rouchka ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Anacardic Acid ◽  
Genome Wide

scholarly journals Oleic acid induces migration through a FFAR1/4, EGFR and AKT-dependent pathway in breast cancer cells

2019 ◽  
Vol 8 (3) ◽  
pp. 252-265 ◽  
Author(s):  
Cleofas Marcial-Medina ◽  
Alejandra Ordoñez-Moreno ◽  
Christian Gonzalez-Reyes ◽  
Pedro Cortes-Reynosa ◽  
Eduardo Perez Salazar
Keyword(s):  
Breast Cancer ◽  
Signal Transduction ◽  
Oleic Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Binding Activity ◽  
Migration And Invasion ◽  
Signal Transduction Pathways ◽  
Dna Binding Activity ◽  
Dependent Pathway

Free fatty acids (FFAs) are an energy source, and induce activation of signal transduction pathways that mediate several biological processes. In breast cancer cells, oleic acid (OA) induces proliferation, matrix metalloproteinase-9 (MMP-9) secretion, migration and invasion. However, the signal transduction pathways that mediate migration and invasion induced by OA in breast cancer cells have not been studied in detail. We demonstrate here that FFAR1 and FFAR4 mediate migration induced by OA in MDA-MB-231 and MCF-7 breast cancer cells. Moreover, OA induces migration, invasion, AKT1 and AKT2 activation, 12-LOX secretion and an increase of NFκB-DNA binding activity in breast cancer cells. Cell migration requires FFAR1, FFAR4, EGFR, AKT and PI3K activity, whereas invasion is mediated though a PI3K/Akt-dependent pathway. Furthermore, OA promotes relocalization of paxillin to focal contacts and it requires PI3K and EGFR activity, whereas NFκB-DNA binding activity requires PI3K and AKT activity.

Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells

2001 ◽  
Vol 37 (3) ◽  
pp. 402-413 ◽  
Author(s):  
J.A. Menéndez ◽  
M. del Mar Barbacid ◽  
S. Montero ◽  
E. Sevilla ◽  
E. Escrich ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oleic Acid ◽  
Cancer Cells ◽  
Linolenic Acid ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Gamma Linolenic Acid

scholarly journals High Metastaticgastric and Breast Cancer Cells Consume Oleic Acid in an AMPK Dependent Manner

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97330 ◽  
Author(s):  
Shuai Li ◽  
Ti Zhou ◽  
Cen Li ◽  
Zhiyu Dai ◽  
Di Che ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oleic Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Dependent Manner
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