Evaluation of the effect of cafeteria diet on the kidney Na,K‐ATPase activity, and oxidative stress

2019 ◽  
Vol 120 (11) ◽  
pp. 19052-19063
Author(s):  
Isadora Reis Restier Pinheiro ◽  
Marina Fátima Nunes Melo ◽  
Sarah Vivas Sousa ◽  
Bárbara Gatti Cardoso ◽  
Thaís Marques da Silva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atpase Activity ◽  
Cafeteria Diet ◽  
And Oxidative Stress

scholarly journals A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats

2017 ◽  
Vol 117 (2) ◽  
pp. 218-229 ◽  
Author(s):  
K. Gil-Cardoso ◽  
I. Ginés ◽  
M. Pinent ◽  
A. Ardévol ◽  
X. Terra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intestinal Inflammation ◽  
Cafeteria Diet ◽  
Zucker Rats ◽  
Standard Diet ◽  
Metabolic Alterations ◽  
Genetic Obesity ◽  
Obesogenic Diet ◽  
The Impact ◽  
And Oxidative Stress

AbstractThe gastrointestinal alterations associated with the consumption of an obesogenic diet, such as inflammation, permeability impairment and oxidative stress, have been poorly explored in both diet-induced obesity (DIO) and genetic obesity. The aim of the present study was to examine the impact of an obesogenic diet on the gut health status of DIO rats in comparison with the Zucker (fa/fa) rat leptin receptor-deficient model of genetic obesity over time. For this purpose, female Wistar rats (n 48) were administered a standard or a cafeteria diet (CAF diet) for 12, 14·5 or 17 weeks and were compared with fa/fa Zucker rats fed a standard diet for 10 weeks. Morphometric variables, plasma biochemical parameters, myeloperoxidase (MPO) activity and reactive oxygen species (ROS) levels in the ileum were assessed, as well as the expressions of proinflammatory genes (TNF-α and inducible nitric oxide synthase (iNOS)) and intestinal permeability genes (zonula occludens-1, claudin-1 and occludin). Both the nutritional model and the genetic obesity model showed increased body weight and metabolic alterations at the final time point. An increase in intestinal ROS production and MPO activity was observed in the gastrointestinal tracts of rats fed a CAF diet but not in the genetic obesity model. TNF-α was overexpressed in the ileum of both CAF diet and fa/fa groups, and ileal inflammation was associated with the degree of obesity and metabolic alterations. Interestingly, the 17-week CAF group and the fa/fa rats exhibited alterations in the expressions of permeability genes. Relevantly, in the hyperlipidic refined sugar diet model of obesity, the responses to chronic energy overload led to time-dependent increases in gut inflammation and oxidative stress.

scholarly journals Swimming training prevents pentylenetetrazol-induced inhibition of Na+, K+-ATPase activity, seizures, and oxidative stress

Epilepsia ◽  
2009 ◽  
Vol 50 (4) ◽  
pp. 811-823 ◽  
Author(s):  
Mauren Assis Souza ◽  
Mauro Schneider Oliveira ◽  
Ana Flávia Furian ◽  
Leonardo Magno Rambo ◽  
Leandro Rodrigo Ribeiro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atpase Activity ◽  
Swimming Training ◽  
And Oxidative Stress

GM1 ganglioside prevents seizures, Na+,K+-ATPase activity inhibition and oxidative stress induced by glutaric acid and pentylenetetrazole

2006 ◽  
Vol 22 (3) ◽  
pp. 611-623 ◽  
Author(s):  
Michele Rechia Fighera ◽  
Luiz Fernando Freire Royes ◽  
Ana Flávia Furian ◽  
Mauro Schneider Oliveira ◽  
Natália Gindri Fiorenza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atpase Activity ◽  
Glutaric Acid ◽  
Gm1 Ganglioside ◽  
Activity Inhibition ◽  
And Oxidative Stress

scholarly journals The Role of Mitochondria in Sex-Dependent Differences in Hepatic Steatosis and Oxidative Stress in Response to Cafeteria Diet-Induced Obesity in Mice

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1618
Author(s):  
Juliana Morais Mewes ◽  
Fabiana Rodrigues Silva Gasparin ◽  
Tiago Yoshida ◽  
Mariana Amâncio Daniel da Silva ◽  
Maria Raquel Marçal Natali ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acid ◽  
Er Stress ◽  
Fatty Acid Oxidation ◽  
Liver Steatosis ◽  
Cafeteria Diet ◽  
Acid Oxidation ◽  
Standard Diet ◽  
Mitochondrial Energy Metabolism ◽  
And Oxidative Stress

Female mice fed a cafeteria diet (FCaf) develop higher liver steatosis and oxidative stress than males (MCaf) as a consequence of unresolved ER stress. Here, we investigated whether mitochondria play a role in this sex difference. The isolated mitochondria from FCaf showed more signs of oxidative stress than those of MCaf, correlated with a reduced content of GSH, increased amount of reactive oxygen species (ROS), and lower activities of enzymes involved in ROS neutralisation. Mitochondria from FCaf and MCaf livers exhibited lower rates of succinate-driven state III respiration and reduced ATPase activity in intact coupled mitochondria compared to their controls fed a standard diet (FC and MC), with no differences between the sexes. Fatty acid oxidation in mitochondria and peroxisomes was higher in MCaf and FCaf compared to their respective controls. In the intact perfused liver, there was no difference between sex or diet regarding the fatty acid oxidation rate. These results indicated that cafeteria diet did not affect mitochondrial energy metabolism, even in FCaf livers, which have higher steatosis and cellular oxidative stress. Nevertheless, the increase in mitochondrial ROS generation associated with a decrease in the antioxidant defence capacity, probably contributes to inducing or reinforcing the ER stress in FCaf livers.

Quercetin treatment regulates the Na + ,K + -ATPase activity, peripheral cholinergic enzymes, and oxidative stress in a rat model of demyelination

2018 ◽  
Vol 55 ◽  
pp. 45-56 ◽  
Author(s):  
Fabiano B. Carvalho ◽  
Jessié M. Gutierres ◽  
Diego Beckmann ◽  
Rosmarini P. Santos ◽  
Gustavo R. Thomé ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atpase Activity ◽  
Rat Model ◽  
And Oxidative Stress ◽  
Quercetin Treatment

Na+,K+-ATPase activity impairment after experimental traumatic brain injury: Relationship to spatial learning deficits and oxidative stress

2008 ◽  
Vol 193 (2) ◽  
pp. 306-310 ◽  
Author(s):  
Frederico Diniz Lima ◽  
Mauren Assis Souza ◽  
Ana Flávia Furian ◽  
Leonardo Magno Rambo ◽  
Leandro Rodrigo Ribeiro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Atpase Activity ◽  
Spatial Learning ◽  
Activity Impairment ◽  
Learning Deficits ◽  
And Oxidative Stress ◽  
Experimental Traumatic Brain Injury

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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