Protective effect of cholecystokinin octapeptide on angiotensin II‐induced apoptosis in H9c2 cardiomyoblast cells

2019 ◽  
Vol 121 (7) ◽  
pp. 3560-3569
Author(s):  
Can Wang ◽  
Huan Yu ◽  
Limu Wei ◽  
Jingqi Zhang ◽  
Mingyang Hong ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Protective Effect ◽  
Cholecystokinin Octapeptide ◽  
Induced Apoptosis ◽  
H9c2 Cardiomyoblast Cells

scholarly journals Protective effect of Danggui (Radix Angelicae Sinensis) on angiotensin II-induced apoptosis in H9c2 cardiomyoblast cells

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Chih-Yang Huang ◽  
Wei-Wen Kuo ◽  
Chia-Hua Kuo ◽  
Fuu-Jen Tsai ◽  
Peng-Yu Liu ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Protective Effect ◽  
Radix Angelicae Sinensis ◽  
Induced Apoptosis ◽  
Angelicae Sinensis ◽  
H9c2 Cardiomyoblast Cells

scholarly journals Protective Effect of Boerhaavia diffusa L. against Mitochondrial Dysfunction in Angiotensin II Induced Hypertrophy in H9c2 Cardiomyoblast Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e96220 ◽  
Author(s):  
Ayyappan Prathapan ◽  
Vadavanath Prabhakaran Vineetha ◽  
Kozhiparambil Gopalan Raghu
Keyword(s):  
Angiotensin Ii ◽  
Protective Effect ◽  
Mitochondrial Dysfunction ◽  
Boerhaavia Diffusa ◽  
H9c2 Cardiomyoblast Cells

The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway

2014 ◽  
Vol 327 (2) ◽  
pp. 264-275 ◽  
Author(s):  
Dae-Eun Kim ◽  
Bokyung Kim ◽  
Hwa-Sup Shin ◽  
Ho Jeong Kwon ◽  
Eun-Seok Park
Keyword(s):  
Hydrogen Peroxide ◽  
Protective Effect ◽  
Signaling Pathway ◽  
Gsk 3Β ◽  
Induced Apoptosis ◽  
H9c2 Cardiomyoblast Cells

Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats

Phytomedicine ◽  
2019 ◽  
Vol 57 ◽  
pp. 1-8 ◽  
Author(s):  
Yeh-Peng Chen ◽  
Kalaiselvi Sivalingam ◽  
Marthandam Asokan Shibu ◽  
Rajendran Peramaiyan ◽  
Cecilia Hsuan Day ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Protective Effect ◽  
Akt Signaling ◽  
Spontaneous Hypertension ◽  
H9c2 Cells ◽  
Induced Apoptosis

Cardioprotective effects of rhamnetin in H9c2 cardiomyoblast cells under H2O2-induced apoptosis

2014 ◽  
Vol 153 (3) ◽  
pp. 552-560 ◽  
Author(s):  
Eun-Seok Park ◽  
Jun Chul Kang ◽  
Yong Chang Jang ◽  
Jong Seok Park ◽  
Shin Yi Jang ◽  
...  
Keyword(s):  
Cardioprotective Effects ◽  
Induced Apoptosis ◽  
H9c2 Cardiomyoblast Cells

scholarly journals Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells

2001 ◽  
Vol 87 (4) ◽  
pp. 289-296 ◽  
Author(s):  
XinShou Ouyang ◽  
Kyoko Takahashi ◽  
Katsuko Komatsu ◽  
Norio Nakamura ◽  
Masao Hattori ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Protective Effect ◽  
Salvia Miltiorrhiza ◽  
Cardiac Cells ◽  
Neonatal Rat

Protective Effect of Docosahexaenoic Acid on Oxidative Stress-Induced Apoptosis of Retina Photoreceptors

2003 ◽  
Vol 44 (5) ◽  
pp. 2252 ◽  
Author(s):  
Nora P. Rotstein ◽  
Luis E. Politi ◽  
O. Lorena German ◽  
Romina Girotti
Keyword(s):  
Oxidative Stress ◽  
Docosahexaenoic Acid ◽  
Protective Effect ◽  
Induced Apoptosis

Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro

2004 ◽  
Vol 286 (3) ◽  
pp. H1063-H1069 ◽  
Author(s):  
Jin-Jiang Pang ◽  
Rong-Kun Xu ◽  
Xiang-Bin Xu ◽  
Ji-Min Cao ◽  
Chao Ni ◽  
...  
Keyword(s):  
Heart Failure ◽  
Angiotensin Ii ◽  
Caspase 3 ◽  
Cardiomyocyte Apoptosis ◽  
Protective Effects ◽  
Ang Ii ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Rat Cardiomyocytes ◽  
Induced Apoptosis

Loss of cardiomyocytes by apoptosis is proposed to cause heart failure. Angiotensin II (ANG II), an important neurohormonal factor during heart failure, can induce cardiomyocyte apoptosis. Inasmuch as hexarelin has been reported to have protective effects in this process, we examined whether hexarelin can prevent cardiomyocytes from ANG II-induced cell death. Cultured cardiomyocytes from neonatal rats were stimulated with ANG II. Apoptosis was evaluated using fluorescence microscopy, TdT-mediated dUTP nick-end labeling (TUNEL) method, flow cytometry, DNA laddering, and analysis of cell viability by (3,4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). It was found that incubation with 0.1 μmol/l ANG II for 48 h increased cardiomyocyte apoptosis. Administration of 0.1 μmol/l hexarelin significantly decreased this ANG II-induced apoptosis and DNA fragmentation and increased myocyte viability. To further investigate the underlying mechanisms, caspase-3 activity assay and mRNA expression of Bax, Bcl-2, and growth hormone secretagogue receptor (GHS-R; the supposed hexarelin binding site) were examined. GHS-R mRNA was abundantly expressed in cardiomyocytes and was upregulated after administration of hexarelin. These results suggest that hexarelin abates cardiomyocytes from ANG II-induced apoptosis possibly via inhibiting the increased caspase-3 activity and Bax expression induced by ANG II and by increasing the expression of Bcl-2, which is depressed by ANG II. Whether the upregulated expression of GHS-R induced by hexarelin is associated with this antiapoptotic effect deserves further investigation.

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