Immunoinformatics based designing a multi‐epitope vaccine against pathogenic Chandipura vesiculovirus

2021 ◽  
Author(s):  
Debashrito Deb ◽  
Srijita Basak ◽  
Tamalika Kar ◽  
Utkarsh Narsaria ◽  
Filippo Castiglione ◽  
...  
Keyword(s):  
Epitope Vaccine

A Novel Recombinant Multi-Epitope Vaccine Could Induce Specific Cytotoxic T Lymphocyte Response In Vitro and In Vivo

2017 ◽  
Vol 24 (6) ◽  
Author(s):  
Yahong Wu ◽  
Wenjie Zhai ◽  
Meng Sun ◽  
Zhe Zou ◽  
Xiuman Zhou ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Response ◽  
Epitope Vaccine ◽  
Cytotoxic T Lymphocyte Response

Epitope vaccine design for the iraqi infectious Bronchitis strains

2018 ◽  
Vol 9 (3) ◽  
Author(s):  
ZAHRA M ◽  
AL- KHAFAJI
Keyword(s):  
Vaccine Design ◽  
Epitope Vaccine ◽  
Infectious Bronchitis

scholarly journals Immunoinformatics-guided design of a multi-epitope vaccine based on the structural proteins of severe acute respiratory syndrome coronavirus 2

RSC Advances ◽  
2021 ◽  
Vol 11 (29) ◽  
pp. 18103-18121
Author(s):  
Ahmad J. Obaidullah ◽  
Mohammed M. Alanazi ◽  
Nawaf A. Alsaif ◽  
Hussam Albassam ◽  
Abdulrahman A. Almehizia ◽  
...  
Keyword(s):  
Tract Infection ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Structural Proteins ◽  
Epitope Vaccine

COVID-19 is caused by SARS-CoV-2, resulting in a contagious respiratory tract infection. For designing a multi-epitope vaccine, we utilized the four structural proteins from the SARS-CoV-2 by using bioinformatics and immunoinformatics analysis.

scholarly journals Protective efficacy by a novel multi-epitope vaccine, including MIC3, ROP8, and SAG1, against acute Toxoplasma gondii infection in BALB/c mice

2021 ◽  
Vol 153 ◽  
pp. 104764
Author(s):  
Samira Dodangeh ◽  
Mahdi Fasihi-Ramandi ◽  
Ahmad Daryani ◽  
Reza Valadan ◽  
Hossein Asgarian-Omran ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Protective Efficacy ◽  
Epitope Vaccine ◽  
Toxoplasma Gondii Infection

scholarly journals Design of a new Multi-Epitope vaccine against Brucella based on T and B cell epitopes using bioinformatics methods

2021 ◽  
pp. 1-41
Author(s):  
Zhiqiang Chen ◽  
Yuejie Zhu ◽  
Tong Sha ◽  
Zhiwei Li ◽  
Yujiao Li ◽  
...  
Keyword(s):  
B Cell ◽  
Epitope Vaccine ◽  
B Cell Epitopes

scholarly journals Design of a multi-epitope vaccine against cervical cancer using immunoinformatics approaches

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Samira Sanami ◽  
Fatemeh Azadegan-Dehkordi ◽  
Mahmoud Rafieian-Kopaei ◽  
Majid Salehi ◽  
Maryam Ghasemi-Dehnoo ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
T Lymphocytes ◽  
Tertiary Structure ◽  
Therapeutic Vaccine ◽  
Epitope Prediction ◽  
Therapeutic Effects ◽  
Epitope Vaccine ◽  
In Vivo Experiments

AbstractCervical cancer, caused by human papillomavirus (HPV), is the fourth most common type of cancer among women worldwide. While HPV prophylactic vaccines are available, they have no therapeutic effects and do not clear up existing infections. This study aims to design a therapeutic vaccine against cervical cancer using reverse vaccinology. In this study, the E6 and E7 oncoproteins from HPV16 were chosen as the target antigens for epitope prediction. Cytotoxic T lymphocytes (CTL) and helper T lymphocytes (HTL) epitopes were predicted, and the best epitopes were selected based on antigenicity, allergenicity, and toxicity. The final vaccine construct was composed of the selected epitopes, along with the appropriate adjuvant and linkers. The multi-epitope vaccine was evaluated in terms of physicochemical properties, antigenicity, and allergenicity. The tertiary structure of the vaccine construct was predicted. Furthermore, several analyses were also carried out, including molecular docking, molecular dynamics (MD) simulation, and in silico cloning of the vaccine construct. The results showed that the final proposed vaccine could be considered an effective therapeutic vaccine for HPV; however, in vitro and in vivo experiments are required to validate the efficacy of this vaccine candidate.

scholarly journals In-silico design of envelope based multi-epitope vaccine candidate against Kyasanur forest disease virus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sathishkumar Arumugam ◽  
Prasad Varamballi
Keyword(s):  
Disease Virus ◽  
In Silico ◽  
Hemorrhagic Fever ◽  
Epitope Vaccine ◽  
Epitope Region ◽  
Vaccine Candidates ◽  
Forest Disease ◽  
In Silico Design ◽  
Antigenic Properties ◽  
Kyasanur Forest Disease

AbstractKyasanur forest disease virus (KFDV) causing tick-borne hemorrhagic fever which was earlier endemic to western Ghats, southern India, it is now encroaching into new geographic regions, but there is no approved medicine or effective vaccine against this deadly disease. In this study, we did in-silico design of multi-epitope subunit vaccine for KFDV. B-cell and T-cell epitopes were predicted from conserved regions of KFDV envelope protein and two vaccine candidates (VC1 and VC2) were constructed, those were found to be non-allergic and possess good antigenic properties, also gives cross-protection against Alkhurma hemorrhagic fever virus. The 3D structures of vaccine candidates were built and validated. Docking analysis of vaccine candidates with toll-like receptor-2 (TLR-2) by Cluspro and PatchDock revealed strong affinity between VC1 and TLR2. Ligplot tool was identified the intermolecular hydrogen bonds between vaccine candidates and TLR-2, iMOD server confirmed the stability of the docking complexes. JCAT sever ensured cloning efficiency of both vaccine constructs and in-silico cloning into pET30a (+) vector by SnapGene showed successful translation of epitope region. IMMSIM server was identified increased immunological responses. Finally, multi-epitope vaccine candidates were designed and validated their efficiency, it may pave the way for up-coming vaccine and diagnostic kit development.

scholarly journals DNA epitope vaccine containing complement component C3d enhances anti-amyloid-β antibody production and polarizes the immune response towards a Th2 phenotype

2008 ◽  
Vol 205 (1-2) ◽  
pp. 57-63 ◽  
Author(s):  
Nina Movsesyan ◽  
Mikayel Mkrtichyan ◽  
Irina Petrushina ◽  
Ted M. Ross ◽  
David H. Cribbs ◽  
...  
Keyword(s):  
Immune Response ◽  
Antibody Production ◽  
Amyloid Β ◽  
Complement Component ◽  
Epitope Vaccine

scholarly journals Designing a multi-epitope vaccine against the Lassa virus through reverse vaccinology, subtractive proteomics, and immunoinformatics approaches

2021 ◽  
pp. 100683
Author(s):  
Akinyemi Ademola Omoniyi ◽  
Samuel Sunday Adebisi ◽  
Sunday Abraham Musa ◽  
James Oliver Nzalak ◽  
Barnabas Danborno ◽  
...  
Keyword(s):  
Reverse Vaccinology ◽  
Lassa Virus ◽  
Epitope Vaccine ◽  
Subtractive Proteomics
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