Stability‐indicating reversed‐phase/normal‐phase high‐performance thin‐layer chromatography technique for the determination of arbidol: Green analytical chemistry viewpoint

2021 ◽  
Author(s):  
Prawez Alam ◽  
Mounir M. Salem‐Bekhit ◽  
Muzaffar Iqbal ◽  
Md. Khalid Anwer ◽  
Mohammed H. Alqarni ◽  
...  
Keyword(s):  
Analytical Chemistry ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Reversed Phase ◽  
Normal Phase ◽  
Green Analytical Chemistry ◽  
Layer Chromatography ◽  
Phase Normal

scholarly journals Simultaneous Determination of Caffeine and Paracetamol in Commercial Formulations Using Greener Normal-Phase and Reversed-Phase HPTLC Methods: A Contrast of Validation Parameters

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 405
Author(s):  
Prawez Alam ◽  
Faiyaz Shakeel ◽  
Abuzer Ali ◽  
Mohammed H. Alqarni ◽  
Ahmed I. Foudah ◽  
...  
Keyword(s):  
Thin Layer ◽  
Simultaneous Determination ◽  
High Performance ◽  
Analytical Techniques ◽  
Reversed Phase ◽  
Normal Phase ◽  
Validation Parameters ◽  
Analytical Approaches ◽  
Layer Chromatography

There has been no assessment of the greenness of the described analytical techniques for the simultaneous determination (SMD) of caffeine and paracetamol. As a result, in comparison to the greener normal-phase high-performance thin-layer chromatography (HPTLC) technique, this research was conducted to develop a rapid, sensitive, and greener reversed-phase HPTLC approach for the SMD of caffeine and paracetamol in commercial formulations. The greenness of both techniques was calculated using the AGREE method. For the SMD of caffeine and paracetamol, the greener normal-phase and reversed-phase HPTLC methods were linear in the 50–500 ng/band and 25–800 ng/band ranges, respectively. For the SMD of caffeine and paracetamol, the greener reversed-phase HPTLC approach was more sensitive, accurate, precise, and robust than the greener normal-phase HPTLC technique. For the SMD of caffeine paracetamol in commercial PANEXT and SAFEXT tablets, the greener reversed-phase HPTLC technique was superior to the greener normal-phase HPTLC approach. The AGREE scores for the greener normal-phase and reversed-phase HPTLC approaches were estimated as 0.81 and 0.83, respectively, indicated excellent greenness profiles for both analytical approaches. The greener reversed-phase HPTLC approach is judged superior to the greener normal-phase HPTLC approach based on numerous validation parameters and pharmaceutical assays.

scholarly journals Ecofriendly densitometric RP-HPTLC method for determination of rivaroxaban in nanoparticle formulations using green solvents

RSC Advances ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 2133-2140 ◽  
Author(s):  
Prawez Alam ◽  
Essam Ezzeldin ◽  
Muzaffar Iqbal ◽  
Md. Khalid Anwer ◽  
Gamal A. E. Mostafa ◽  
...  
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Reversed Phase ◽  
Literature Survey ◽  
Green Solvents ◽  
Layer Chromatography ◽  
Hptlc Method

A literature survey revealed no suitable “reversed phase-high performance thin layer chromatography (RP-HPTLC)” method for the analysis of rivaroxaban in nanoparticle (NP) formulations.

Determination of losartan and its degradates in COZAAR® tablets by reversed-phase high-performance thin-layer chromatography

1998 ◽  
Vol 17 (4-5) ◽  
pp. 671-677 ◽  
Author(s):  
Kathleen E McCarthy ◽  
Qingxi Wang ◽  
Eric W Tsai ◽  
Rebecca E Gilbert ◽  
Dominic P Ip ◽  
...  
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Reversed Phase ◽  
Layer Chromatography
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