scholarly journals Circulating long noncoding RNA ANRIL downregulation correlates with increased risk, higher disease severity and elevated pro-inflammatory cytokines in patients with acute ischemic stroke

2018 ◽  
Vol 33 (1) ◽  
pp. e22629 ◽  
Author(s):  
Lijuan Feng ◽  
Jun Guo ◽  
Fen Ai
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Disease Severity ◽  
Inflammatory Cytokines ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Increased Risk ◽  
Pro Inflammatory Cytokines

Acute Ischemic Stroke is Associated with Increased Serum Levels of Pro-inflammatory Cytokines

2020 ◽  
Author(s):  
Bhagirath Ramawat ◽  
Alvee Saluja ◽  
Jayashree Bhatacharjee ◽  
Anshuman Srivastava ◽  
Rajinder K. Dhamija
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Inflammatory Cytokines ◽  
Serum Levels ◽  
Pro Inflammatory Cytokines

scholarly journals Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Coral Torres-Querol ◽  
Pascual Torres ◽  
Noemí Vidal ◽  
Manel Portero-Otín ◽  
Gloria Arque ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Mouse Model ◽  
Human Brain ◽  
Acute Ischemic Stroke ◽  
Brain Tissue ◽  
Inflammatory Cytokines ◽  
Microglial Cells ◽  
Infarct Area ◽  
Secretory Phenotype ◽  
Pro Inflammatory Cytokines

AbstractSenescent cells are capable of expressing a myriad of inflammatory cytokines and this pro-inflammatory phenomenon is known as senescence-associated secretory phenotype (SASP). The contribution of this phenomenon in brain ischemia was scarce. A mouse model of transient focal cerebral ischemia by compressing the distal middle cerebral artery (tMCAo) for 60 min was used. SASP, pro-inflammatory cytokines and cell cycle mRNAs levels were quantified at 30-min and 72 h post-surgery. Immunohistochemistry in paraffin embedded human brain slides and mouse brain tissue was performed. Our results showed an increase of both p16 and p21 mRNA restricted to the infarct area in the tMCAo brain. Moreover, there was an induction of Il6, Tnfa, Cxc11, and its receptor Cxcr2 mRNA pro-inflammatory cytokines with a high positive correlation with p16/p21 mRNA levels. The p16 was mainly shown in cytoplasm of neurons and cytoplasm/membrane of microglial cells. The p21 was observed in membrane of neurons and also it showed a mixed cytoplasmic and membranous pattern in the microglial cells. In a human stroke patient, an increase of P16 in the perimeter of the MCA infarct area was observed. These suggest a role of SASP in tMCAo mouse model and in human brain tissue. SASP potentially has a physiological role in acute ischemic stroke and neurological function loss.

Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome

2008 ◽  
Vol 41 (16-17) ◽  
pp. 1330-1334 ◽  
Author(s):  
Vanja Basic Kes ◽  
Ana-Maria Simundic ◽  
Nora Nikolac ◽  
Elizabeta Topic ◽  
Vida Demarin
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Inflammatory Cytokines ◽  
Neurological Deficit ◽  
Stroke Outcome ◽  
Anti Inflammatory
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