Retinoic acid priming potentiates the induction of urokinase-type plasminogen activator by cyclic adenosine monophosphate in mouse mammary carcinoma cells

1991 ◽  
Vol 147 (1) ◽  
pp. 46-54 ◽  
Author(s):  
Rafael Mira-Y-Lopez
Keyword(s):  
Retinoic Acid ◽  
Plasminogen Activator ◽  
Mammary Carcinoma ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Carcinoma Cells ◽  
Mouse Mammary Carcinoma ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Mammary Carcinoma Cells

scholarly journals Activation and proliferation signals in murine macrophages. Biochemical signals controlling the regulation of macrophage urokinase-type plasminogen activator activity by colony-stimulating factors and other agents

Blood ◽  
1991 ◽  
Vol 77 (3) ◽  
pp. 616-627 ◽  
Author(s):  
JA Hamilton ◽  
G Vairo ◽  
KR Knight ◽  
BG Cocks
Keyword(s):  
Plasminogen Activator ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Peritoneal Macrophages ◽  
Mrna Levels ◽  
Hematopoietic Growth Factors ◽  
Murine Bone Marrow ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Biochemical Signals

Abstract Purified hematopoietic growth factors such as colony-stimulating factor- 1 (CSF-1) or macrophage CSF, granulocyte-macrophage CSF, and interleukin-3 or multi-CSF, stimulate the urokinase-type plasminogen activator (u-PA) activity of murine bone marrow-derived macrophages (BMM) and resident peritoneal macrophages. Granulocyte-CSF was inactive. The increases in BMM u-PA activity were inhibited by the glucocorticoid dexamethasone, and by agents that raise intracellular cyclic adenosine monophosphate levels, including prostaglandin E2 and cholera toxin. These changes in u-PA activity were paralleled by corresponding changes in u-PA mRNA levels. Evidence was obtained for protein kinase C and phospholipase C-mediated stimulation of BMM u-PA activity and mRNA levels; however, no evidence was found for an involvement of Na+/H+ exchange or Na+, K(+)-ATPase activity, Ca2+ fluxes, or pertussis toxin-sensitive G proteins. Several findings point to a dissociation between macrophage u-PA expression and DNA synthesis.

scholarly journals Activation and proliferation signals in murine macrophages. Biochemical signals controlling the regulation of macrophage urokinase-type plasminogen activator activity by colony-stimulating factors and other agents

Blood ◽  
1991 ◽  
Vol 77 (3) ◽  
pp. 616-627
Author(s):  
JA Hamilton ◽  
G Vairo ◽  
KR Knight ◽  
BG Cocks
Keyword(s):  
Plasminogen Activator ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Peritoneal Macrophages ◽  
Mrna Levels ◽  
Hematopoietic Growth Factors ◽  
Murine Bone Marrow ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Biochemical Signals

Purified hematopoietic growth factors such as colony-stimulating factor- 1 (CSF-1) or macrophage CSF, granulocyte-macrophage CSF, and interleukin-3 or multi-CSF, stimulate the urokinase-type plasminogen activator (u-PA) activity of murine bone marrow-derived macrophages (BMM) and resident peritoneal macrophages. Granulocyte-CSF was inactive. The increases in BMM u-PA activity were inhibited by the glucocorticoid dexamethasone, and by agents that raise intracellular cyclic adenosine monophosphate levels, including prostaglandin E2 and cholera toxin. These changes in u-PA activity were paralleled by corresponding changes in u-PA mRNA levels. Evidence was obtained for protein kinase C and phospholipase C-mediated stimulation of BMM u-PA activity and mRNA levels; however, no evidence was found for an involvement of Na+/H+ exchange or Na+, K(+)-ATPase activity, Ca2+ fluxes, or pertussis toxin-sensitive G proteins. Several findings point to a dissociation between macrophage u-PA expression and DNA synthesis.

Nucleolar Succinic Dehydrogenase in Mouse Mammary Carcinoma Cells

Nature ◽  
1961 ◽  
Vol 192 (4799) ◽  
pp. 285-286 ◽  
Author(s):  
P. DE ◽  
R. CHATTERJEE ◽  
S. MITRA
Keyword(s):  
Mammary Carcinoma ◽  
Succinic Dehydrogenase ◽  
Carcinoma Cells ◽  
Mouse Mammary Carcinoma ◽  
Mammary Carcinoma Cells

scholarly journals Identification of Histone H2A.X as a Growth Factor Secreted by an Androgen-independent Subline of Mouse Mammary Carcinoma Cells

1996 ◽  
Vol 271 (41) ◽  
pp. 25126-25130 ◽  
Author(s):  
Yoshio Watabe ◽  
Hiroaki Kuramochi ◽  
Yuzo Furuya ◽  
Nobuya Inagaki ◽  
Susumu Seino ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mammary Carcinoma ◽  
Carcinoma Cells ◽  
Mouse Mammary Carcinoma ◽  
Mammary Carcinoma Cells ◽  
Androgen Independent

scholarly journals Tumorigenic WAP-T Mouse Mammary Carcinoma Cells: A Model for a Self-Reproducing Homeostatic Cancer Cell System

PLoS ONE ◽  
2010 ◽  
Vol 5 (8) ◽  
pp. e12103 ◽  
Author(s):  
Florian Wegwitz ◽  
Mark-Andreas Kluth ◽  
Claudia Mänz ◽  
Benjamin Otto ◽  
Katharina Gruner ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Mammary Carcinoma ◽  
Cell System ◽  
Carcinoma Cells ◽  
Mouse Mammary Carcinoma ◽  
Mammary Carcinoma Cells
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