Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion

2005 ◽  
Vol 204 (1) ◽  
pp. 198-209 ◽  
Author(s):  
Shelly R. Peyton ◽  
Andrew J. Putnam
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Motility ◽  
Muscle Cell ◽  
Matrix Rigidity

scholarly journals Chronic Mineral Dysregulation Promotes Vascular Smooth Muscle Cell Adaptation and Extracellular Matrix Calcification

2009 ◽  
Vol 21 (1) ◽  
pp. 103-112 ◽  
Author(s):  
Rukshana C. Shroff ◽  
Rosamund McNair ◽  
Jeremy N. Skepper ◽  
Nichola Figg ◽  
Leon J. Schurgers ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Adaptation

scholarly journals A link between smooth muscle cell death and extracellular matrix degradation during vascular atrophy

2011 ◽  
Vol 54 (1) ◽  
pp. 182-191.e24 ◽  
Author(s):  
Richard D. Kenagy ◽  
Seung-Kee Min ◽  
Eileen Mulvihill ◽  
Alexander W. Clowes
Keyword(s):  
Extracellular Matrix ◽  
Cell Death ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Matrix Degradation ◽  
Extracellular Matrix Degradation

scholarly journals SUN2 accumulation contributes to vascular smooth muscle cell alterations induced by matrix rigidity

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Néjma Bélaadi ◽  
Gilliane Chadeuf ◽  
Luan Nguyen ◽  
Marc Rio ◽  
Guy Louarn ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Matrix Rigidity ◽  
Cell Alterations

Comparable Inhibitory Action of PGE1 and 13,14-dihydro-PGE1 on Smooth Muscle Cell Activity and Extracellular Matrix Production

1991 ◽  
pp. 33-38
Author(s):  
I. Neumann ◽  
P. Fitscha ◽  
J. O’grady ◽  
B. A. Peskar ◽  
H. Sinzinger
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Inhibitory Action ◽  
Cell Activity ◽  
Extracellular Matrix Production ◽  
Matrix Production

Role of PTP-1B in aortic smooth muscle cell motility and tyrosine phosphorylation of focal adhesion proteins

1999 ◽  
Vol 277 (1) ◽  
pp. H192-H198 ◽  
Author(s):  
Aviv Hassid ◽  
Shile Huang ◽  
Jian Yao
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Motility ◽  
Muscle Cell ◽  
Focal Adhesion ◽  
Adhesion Proteins ◽  
Focal Adhesion Proteins ◽  
Base Mismatch ◽  
Ptp 1B

Recent studies have focused attention on the role of protein tyrosine kinases in vascular smooth muscle cell biology, but similar information regarding protein tyrosine phosphatases (PTP) is sparse. PTP-1B is a ubiquitous nonreceptor phosphatase with uncertain function and substrates that are mostly unidentified. We used antisense oligodeoxynucleotides (ODN) against PTP-1B to investigate the role of endogenous PTP-1B in motility of primary cultures of rat aortic smooth muscle cells (RASMC). Antisense ODN decreased PTP-1B protein levels and activity in a concentration-dependent fashion, whereas sense, scrambled, or three-base mismatch antisense ODN had little or no effect. Treatment of cells with antisense ODN, but not sense, scrambled, or three-base mismatch antisense ODN, enhanced cell motility and increased tyrosine phosphorylation levels of focal adhesion proteins paxillin, p130cas, and focal adhesion kinase. Our findings indicate that PTP-1B is a negative regulator of RASMC motility via modulation of phosphotyrosine levels in several focal adhesion proteins and suggest the involvement of PTP-1B in events such as atherosclerosis and restenosis, which are associated with increased vascular smooth muscle cell motility.

Extracellular matrix presentation modulates vascular smooth muscle cell mechanotransduction

2015 ◽  
Vol 41 ◽  
pp. 36-43 ◽  
Author(s):  
Olga V. Sazonova ◽  
Brett C. Isenberg ◽  
Jacob Herrmann ◽  
Kristen L. Lee ◽  
Alberto Purwada ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell

scholarly journals Involvement of cAMP-response element binding protein-1 in arachidonic acid-induced vascular smooth muscle cell motility

2005 ◽  
Vol 47 (4) ◽  
pp. 767-777 ◽  
Author(s):  
Nagadhara Dronadula ◽  
Farhan Rizvi ◽  
Eva Blaskova ◽  
Quanyi Li ◽  
Gadiparthi N. Rao
Keyword(s):  
Arachidonic Acid ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Motility ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Camp Response Element Binding ◽  
Camp Response Element ◽  
Element Binding Protein

Smooth muscle cell biglycan overexpression results in increased lipoprotein retention on extracellular matrix: implications for the retention of lipoproteins in atherosclerosis

2004 ◽  
Vol 177 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Kevin D. O’Brien ◽  
Katherine Lewis ◽  
Jens W. Fischer ◽  
Pamela Johnson ◽  
Jin-Yong Hwang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Lipoprotein Retention

Impact of Endothelial Cells and Mechanical Conditioning on Smooth Muscle Cell Extracellular Matrix Production and Differentiation

2009 ◽  
Vol 15 (4) ◽  
pp. 815-825 ◽  
Author(s):  
Allen S. Bulick ◽  
Dany J. Muñoz-Pinto ◽  
Xin Qu ◽  
Mousami Mani ◽  
Deissy Cristancho ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cells ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Mechanical Conditioning ◽  
Extracellular Matrix Production ◽  
Matrix Production
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