scholarly journals Population Pharmacokinetic Modeling and Dosing Simulations of Nitrogen‐Scavenging Compounds: Disposition of Glycerol Phenylbutyrate and Sodium Phenylbutyrate in Adult and Pediatric Patients with Urea Cycle Disorders

2013 ◽  
Vol 53 (7) ◽  
pp. 699-710 ◽  
Author(s):  
Jon P. R. Monteleone ◽  
M. Mokhtarani ◽  
G. A. Diaz ◽  
W. Rhead ◽  
U. Lichter‐Konecki ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Urea Cycle ◽  
Pharmacokinetic Modeling ◽  
Population Pharmacokinetic ◽  
Urea Cycle Disorders ◽  
Population Pharmacokinetic Modeling ◽  
Cycle Disorders ◽  
Nitrogen Scavenging ◽  
Sodium Phenylbutyrate

scholarly journals Ammonia control in children with urea cycle disorders (UCDs); Phase 2 comparison of sodium phenylbutyrate and glycerol phenylbutyrate

2011 ◽  
Vol 103 (4) ◽  
pp. 323-329 ◽  
Author(s):  
Uta Lichter-Konecki ◽  
G.A. Diaz ◽  
J.L. Merritt ◽  
A. Feigenbaum ◽  
C. Jomphe ◽  
...  
Keyword(s):  
Urea Cycle ◽  
Urea Cycle Disorders ◽  
Phase 2 ◽  
Cycle Disorders ◽  
Sodium Phenylbutyrate

scholarly journals Sodium phenylbutyrate decreases plasma branched-chain amino acids in patients with urea cycle disorders

2014 ◽  
Vol 113 (1-2) ◽  
pp. 131-135 ◽  
Author(s):  
Lindsay C. Burrage ◽  
Mahim Jain ◽  
Laura Gandolfo ◽  
Brendan H. Lee ◽  
Sandesh C.S. Nagamani
Keyword(s):  
Amino Acids ◽  
Urea Cycle ◽  
Branched Chain Amino Acids ◽  
Urea Cycle Disorders ◽  
Branched Chain ◽  
Cycle Disorders ◽  
Sodium Phenylbutyrate

scholarly journals Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: Safety, pharmacokinetics and ammonia control

2010 ◽  
Vol 100 (3) ◽  
pp. 221-228 ◽  
Author(s):  
Brendan Lee ◽  
William Rhead ◽  
George A. Diaz ◽  
Bruce F. Scharschmidt ◽  
Asad Mian ◽  
...  
Keyword(s):  
Urea Cycle ◽  
Urea Cycle Disorders ◽  
Phase 2 ◽  
Cycle Disorders ◽  
Sodium Phenylbutyrate

Population Pharmacokinetic Modeling of Epoetin Delta in Pediatric Patients With Chronic Kidney Disease

2008 ◽  
Vol 48 (7) ◽  
pp. 837-848 ◽  
Author(s):  
William Knebel ◽  
Mary Palmen ◽  
James A. Dowell ◽  
Marc Gastonguay
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Pediatric Patients ◽  
Pharmacokinetic Modeling ◽  
Population Pharmacokinetic ◽  
Population Pharmacokinetic Modeling

scholarly journals Gentamicin Population Pharmacokinetics in Pediatric Patients—A Prospective Study with Data Analysis Using the saemix Package in R

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1596
Author(s):  
Paolo Paioni ◽  
Vera F. Jäggi ◽  
Romy Tilen ◽  
Michelle Seiler ◽  
Philipp Baumann ◽  
...  
Keyword(s):  
Prospective Study ◽  
Plasma Levels ◽  
Pediatric Patients ◽  
Plasma Concentrations ◽  
Compartment Model ◽  
R Package ◽  
Pharmacokinetic Modeling ◽  
Therapeutic Window ◽  
Population Pharmacokinetic ◽  
Population Pharmacokinetic Modeling

The aminoglycoside gentamicin is used for the empirical treatment of pediatric infections. It has a narrow therapeutic window. In this prospective study at University Children’s Hospital Zurich, Switzerland, we aimed to characterize the pharmacokinetics of gentamicin in pediatric patients and predict plasma concentrations at typical recommended doses. We recruited 109 patients aged from 1 day to 14 years, receiving gentamicin (7.5 mg/kg at age ≥ 7 d or 5 mg/kg). Plasma levels were determined 30 min, 4 h and 24 h after the infusion was stopped and then transferred, together with patient data, to the secure BioMedIT node Leonhard Med. Population pharmacokinetic modeling was performed with the open-source R package saemix on the SwissPKcdw platform in Leonhard Med. Data followed a two-compartment model. Bodyweight, plasma creatinine and urea were identified as covariates for clearance, with bodyweight as a covariate for central and peripheral volumes of distribution. Simulations with 7.5 mg/kg revealed a 95% CI of 13.0–21.2 mg/L plasma concentration at 30 min after the stopping of a 30-min infusion. At 24 h, 95% of simulated plasma levels were < 1.8 mg/L. Our study revealed that the recommended dosing is appropriate. It showed that population pharmacokinetic modeling using R provides high flexibility in a secure environment.

Liver transplantation for urea cycle disorders in pediatric patients: A single-center experience

2013 ◽  
Vol 17 (2) ◽  
pp. 158-167 ◽  
Author(s):  
Irene K. Kim ◽  
Anna-Kaisa Niemi ◽  
Casey Krueger ◽  
Clark A. Bonham ◽  
Waldo Concepcion ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Pediatric Patients ◽  
Urea Cycle ◽  
Urea Cycle Disorders ◽  
Single Center ◽  
Single Center Experience ◽  
Cycle Disorders
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