Choline chloride modulates learning, memory, and synaptic plasticity impairments in maternally separated adolescent male rats

2021 ◽  
Author(s):  
Sarieh Shahraki ◽  
Khadijeh Esmaeilpour ◽  
Mohammad Shabani ◽  
Gholamreza Sepehri ◽  
Mohammad Amin Rajizadeh ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Choline Chloride ◽  
Male Rats ◽  
Adolescent Male

scholarly journals Nandrolone administration abolishes hippocampal fEPSP-PS potentiation and passive avoidance learning of adolescent male rats

2019 ◽  
Vol 97 (2) ◽  
pp. 130-139 ◽  
Author(s):  
Fatemeh Zarei ◽  
Farshad Moradpour ◽  
Ahmad Ali Moazedi ◽  
Ali Pourmotabbed ◽  
Mozhgan Veisi
Keyword(s):  
Synaptic Plasticity ◽  
Passive Avoidance ◽  
Avoidance Learning ◽  
Serum Levels ◽  
Acute Effect ◽  
Passive Avoidance Learning ◽  
Male Rats ◽  
Adolescent Male ◽  
Excitatory Postsynaptic Potential ◽  
Postsynaptic Potential

Despite the chronic effects of nandrolone decanoate (ND), the acute effects of ND on passive avoidance learning (PAL) and memory and its mechanism have not been investigated. This research examines the acute effect of ND on PAL, CA1 synaptic plasticity, testosterone and corticosterone serum levels, and the role of androgenic receptors (ARs). Adolescent male rats were treated with ND, 30 min before training and retention and after training test. AR antagonist was applied 15 min before ND. Hippocampal slices were perfused by ND. ND administration had an inverted U-shape effect on acquisition of PAL and on testosterone and corticosterone serum levels. The consolidation was only affected by high dose of ND. ND significantly decreased the retention of PAL across all doses. The magnitude of field excitatory postsynaptic potential long term potentiation was lower than that of control slices. In addition, an attenuation of field excitatory postsynaptic potential population spike coupling was also observed. Nilutamide could nullify the ND impairment effect. We concluded although a single dose of ND could affect all stages of PAL, its effects were more potent on retrieval, possibly arising from the acute effect of ND on the alterations of CA1 synaptic plasticity. In addition, ND may induce its effects directly through ARs and indirectly through plasma testosterone and corticosterone.

Anastrozole Eliminates the Improvement Effects of Nandrolone on Hippocampal Synaptic Plasticity in Adolescent Male Rats

2021 ◽  
Vol 48 (6) ◽  
pp. 783-792
Author(s):  
Zahra Salimi ◽  
Ali Pourmotabbed ◽  
Seyed Ershad Nedaei ◽  
Mohammad Rasool Khazaei ◽  
Farshad Moradpour ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Male Rats ◽  
Adolescent Male ◽  
Hippocampal Synaptic Plasticity

scholarly journals Adolescent male rats exposed to social defeat exhibit altered anxiety behavior and limbic monoamines as adults.

2009 ◽  
Vol 123 (3) ◽  
pp. 564-576 ◽  
Author(s):  
Michael J. Watt ◽  
Andrew R. Burke ◽  
Kenneth J. Renner ◽  
Gina L. Forster
Keyword(s):  
Social Defeat ◽  
Male Rats ◽  
Adolescent Male ◽  
Anxiety Behavior

scholarly journals Discordant Effects of Cannabinoid 2 Receptor Antagonism/Inverse Agonism During Adolescence on Pavlovian and Instrumental Reward Learning in Adult Male Rats

2021 ◽  
Vol 13 ◽  
Author(s):  
Danna Ellner ◽  
Bryana Hallam ◽  
Jude A. Frie ◽  
Hayley H. A. Thorpe ◽  
Muhammad Shoaib ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Critical Role ◽  
Behavioral Outcomes ◽  
Endocannabinoid System ◽  
Developmental Trajectory ◽  
Male Rats ◽  
Reward Learning ◽  
Adolescent Male ◽  
High Dose ◽  
Lever Pressing

The endocannabinoid system is responsible for regulating a spectrum of physiological activities and plays a critical role in the developing brain. During adolescence, the endocannabinoid system is particularly sensitive to external insults that may change the brain’s developmental trajectory. Cannabinoid receptor type 2 (CB2R) was initially thought to predominantly function in the peripheral nervous system, but more recent studies have implicated its role in the mesolimbic pathway, a network largely attributed to reward circuitry and reward motivated behavior, which undergoes extensive changes during adolescence. It is therefore important to understand how CB2R modulation during adolescence can impact reward-related behaviors in adulthood. In this study, adolescent male rats (postnatal days 28–41) were exposed to a low or high dose of the CB2R antagonist/inverse agonist SR144528 and Pavlovian autoshaping and instrumental conditional behavioral outcomes were measured in adulthood. SR144528-treated rats had significantly slower acquisition of the autoshaping task, seen by less lever pressing behavior over time [F(2, 19) = 5.964, p = 0.010]. Conversely, there was no effect of adolescent SR144528 exposure on instrumental conditioning. These results suggest that modulation of the CB2R in adolescence differentially impacts reward-learning behaviors in adulthood.

Nicotine-induced impairments of spatial cognition and long-term potentiation in adolescent male rats

2013 ◽  
Vol 33 (2) ◽  
pp. 203-213 ◽  
Author(s):  
G Han ◽  
L An ◽  
B Yang ◽  
L Si ◽  
T Zhang
Keyword(s):  
Young Adult ◽  
Learning And Memory ◽  
Long Term Potentiation ◽  
Male Rats ◽  
Adolescent Male ◽  
Control Group ◽  
Adult Offspring ◽  
Behavioral Impairment ◽  
Term Potentiation

The aim of the present study was to investigate whether cognitive behavioral impairment, induced by nicotine in offspring rats, was associated with the alteration of hippocampal short-term potentiation (STP) and long-term potentiation (LTP) and to discuss the potential underlying mechanism. Young adult offspring rats were randomly divided into three groups. The groups include: control group (CC), nicotine group 1 (NC), in which their mothers received nicotine from gestational day 3 (GD3) to GD18, and nicotine group 2 (CN), in which young adult offspring rats received nicotine from postnatal day 42 (PD42) to PD56. Morris water maze (MWM) test was performed and then field excitatory postsynaptic potentials elicited by the stimulation of perforant pathway were recorded in the hippocampal dentate gyrus region. The results of the MWM test showed that learning and memory were impaired by either prenatal or postnatal nicotine exposure. In addition, it was found that there was no statistical difference of the MWM data between both nicotine treatments. In the electrophysiological test, LTP and STP were significantly inhibited in both NC and CN groups in comparison with the CC group. Notably, STP in CN group was also lower than that in the NC group. These findings suggested that both prenatal and postnatal exposure to nicotine induced learning and memory deficits, while the potential mechanism might be different from each other due to their dissimilar impairments of synaptic plasticity.

scholarly journals Effects of long‐term paroxetine or bupropion treatment on puberty onset, reproductive and feeding parameters in adolescent male rats

Andrologia ◽  
2019 ◽  
Vol 51 (6) ◽  
pp. e13268 ◽  
Author(s):  
Ahmet Yardimci ◽  
Nazife Ulker ◽  
Ozgur Bulmus ◽  
Nalan Kaya ◽  
Neriman Colakoglu ◽  
...  
Keyword(s):  
Male Rats ◽  
Adolescent Male ◽  
Feeding Parameters ◽  
Puberty Onset

Repeated exposure to chlorpyrifos alters the performance of adolescent male rats in animal models of depression and anxiety

2011 ◽  
Vol 32 (4) ◽  
pp. 355-361 ◽  
Author(s):  
Wen-Qiang Chen ◽  
Li Yuan ◽  
Rui Xue ◽  
Yun-Feng Li ◽  
Rui-Bin Su ◽  
...  
Keyword(s):  
Animal Models ◽  
Repeated Exposure ◽  
Male Rats ◽  
Adolescent Male ◽  
Depression And Anxiety ◽  
Animal Models Of Depression

scholarly journals The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats

2018 ◽  
Vol 34 (3) ◽  
pp. 525-537 ◽  
Author(s):  
Katarzyna Kamińska ◽  
Karolina Noworyta-Sokołowska ◽  
Anna Górska ◽  
Joanna Rzemieniec ◽  
Agnieszka Wnuk ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Glutamate Release ◽  
Cortical Cell ◽  
Synaptic Cleft ◽  
In Vivo Microdialysis ◽  
Male Rats ◽  
Adolescent Male ◽  
Turnover Rates ◽  
Adult Rats

Abstract According to the European Drug Report (2016), the use of synthetic cathinones, such as mephedrone, among young people has rapidly increased in the last years. Studies in humans indicate that psychostimulant drug use in adolescence increases risk of drug abuse in adulthood. Mephedrone by its interaction with transporters for dopamine (DAT) and serotonin (SERT) stimulates their release to the synaptic cleft. In animal studies, high repeated doses of mephedrone given to adolescent but not adult mice or rats induced toxic changes in 5-hydroxytryptamine (5-HT) neurons. The aim of our study was to investigate the effects of mephedrone given in adolescence on brain neurotransmission and possible neuronal injury in adult rats. Adolescent male rats were given mephedrone (5 mg/kg) for 8 days. In vivo microdialysis in adult rats showed an increase in dopamine (DA), 5-HT, and glutamate release in the nucleus accumbens and frontal cortex but not in the striatum in response to challenge dose in animals pretreated with mephedrone in adolescence. The 5-HT and 5-hydroxyindoleacetic acid contents decreased in the striatum and nucleus accumbens while DA turnover rates were decreased in the striatum and nucleus accumbens. The oxidative damage of DNA assessed with the alkaline comet assay was found in the cortex of adult rats. Therefore, the administration of repeated low doses of mephedrone during adolescence does not seem to induce injury to 5-HT and DA neurons. The oxidative stress seems to be responsible for possible damage of cortical cell bodies which causes maladaptive changes in serotonergic and dopaminergic neurons.

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