scholarly journals High TSPAN8 expression in epithelial cancer cell‐derived small extracellular vesicles promote confined diffusion and pronounced uptake

2021 ◽  
Vol 10 (13) ◽  
Author(s):  
Teng Wang ◽  
Xin Wang ◽  
Haobin Wang ◽  
Luhan Li ◽  
Chenhong Zhang ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Extracellular Vesicles ◽  
Epithelial Cancer

Invasion Suppressor Role of E-Cadherin in Epithelial Cancer Cell Lines

1997 ◽  
Vol 9 (4) ◽  
pp. 263
Author(s):  
Joo Young Roh ◽  
Chong Ju Lee
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Epithelial Cancer ◽  
E Cadherin

scholarly journals Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles

2017 ◽  
Vol 6 (1) ◽  
pp. 1354645 ◽  
Author(s):  
Elisa Lázaro-Ibáñez ◽  
Maarit Neuvonen ◽  
Maarit Takatalo ◽  
Uma Thanigai Arasu ◽  
Cristian Capasso ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Extracellular Vesicles ◽  
Prostate Cancer Cell

scholarly journals Pre-treatment with tannic acid inhibits the intracellular IL-8 production by chitosan in a human oral epithelial cancer cell line

2009 ◽  
Vol 13 (4) ◽  
pp. 135-141 ◽  
Author(s):  
Hidetaka Ishizaki ◽  
Shizuka Yamada ◽  
Kajiro Yanagiguchi ◽  
Zenya Koyama ◽  
Takeshi Ikeda ◽  
...  
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Tannic Acid ◽  
Cancer Cell Line ◽  
Epithelial Cancer ◽  
Pre Treatment ◽  
Oral Epithelial

scholarly journals The n-10 Fatty Acids Family in the Lipidome of Human Prostatic Adenocarcinoma Cell Membranes and Extracellular Vesicles

2020 ◽  
Author(s):  
Carla Ferreri ◽  
Anna Sansone ◽  
Sandra Buratta ◽  
Lorena Urbanelli ◽  
Eva Costanzi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Extracellular Vesicles ◽  
Cell Membranes ◽  
Saturated Fatty Acids ◽  
Prostatic Adenocarcinoma ◽  
Fatty Acid Isomer ◽  
Adenocarcinoma Cell

A new pathway leading to the n-10 fatty acid series has been recently evidenced, starting from sapienic acid - a monounsaturated fatty acid (MUFA) resulting from the transformation of palmitic acid by delta-6 desaturase. Sapienic acid attracts attention as novel marker of cancer cell plasticity. Here, we analyzed fatty acids including the n-10 fatty acid contents, and compared for the first time cell membranes and the corresponding extracellular vesicles (EV) of two human prostatic adenocarcinoma cell lines of different aggressiveness (PC3 and LNCaP). The n-10 components were 9-13% of the total fatty acids in both cancer cell lines and EVs, with total MUFA levels significantly higher in EVs of the most aggressive cell type (PC3). High sapienic/palmitoleic ratios indicated the preference for delta-6 vs. delta-9 desaturase enzymatic activity in these cell lines. The expressions analysis of enzymes involved in desaturation and elongation by qRT-PCR showed a higher desaturase activity in PC3 and a higher elongase activity toward polyunsaturated fatty acids than toward saturated fatty acids, compared to LNCaP cells. Our results improve the present knowledge in cancer fatty acid metabolism and lipid phenotypes, highlighting EV lipidomics to monitor positional fatty acid isomer profiles and MUFA levels in cancer.

scholarly journals Cancer Alters the Metabolic Fingerprint of Extracellular Vesicles

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3292
Author(s):  
Mari Palviainen ◽  
Kirsi Laukkanen ◽  
Zeynep Tavukcuoglu ◽  
Vidya Velagapudi ◽  
Olli Kärkkäinen ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Extracellular Vesicles ◽  
Western Blotting ◽  
Cell Metabolism ◽  
Cancer Cell Lines ◽  
Cancerous Cell ◽  
Metabolic Fingerprint ◽  
And Control

Cancer alters cell metabolism. How these changes are manifested in the metabolite cargo of cancer-derived extracellular vesicles (EVs) remains poorly understood. To explore these changes, EVs from prostate, cutaneous T-cell lymphoma (CTCL), colon cancer cell lines, and control EVs from their noncancerous counterparts were isolated by differential ultracentrifugation and analyzed by nanoparticle tracking analysis (NTA), electron microscopy (EM), Western blotting, and liquid chromatography-mass spectrometry (LC-MS). Although minor differences between the cancerous and non-cancerous cell-derived EVs were observed by NTA and Western blotting, the largest differences were detected in their metabolite cargo. Compared to EVs from noncancerous cells, cancer EVs contained elevated levels of soluble metabolites, e.g., amino acids and B vitamins. Two metabolites, proline and succinate, were elevated in the EV samples of all three cancer types. In addition, folate and creatinine were elevated in the EVs from prostate and CTCL cancer cell lines. In conclusion, we present the first evidence in vitro that the altered metabolism of different cancer cells is reflected in common metabolite changes in their EVs. These results warrant further studies on the significance and usability of this metabolic fingerprint in cancer.

Evaluation of the effects of extracellular vesicles derived from Faecalibacterium prausnitzii on lung cancer cell line

Biologia ◽  
2019 ◽  
Vol 74 (7) ◽  
pp. 889-898 ◽  
Author(s):  
Behnoush Jafari ◽  
Ramazan Ali Khavari Nejad ◽  
Farzam Vaziri ◽  
Seyed Davar Siadat
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Extracellular Vesicles ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell ◽  
Faecalibacterium Prausnitzii
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