Design, Synthesis and Molecular Modeling of Nonsteroidal Anti‐inflammatory Drugs Tagged Substituted 1,2,3‐Triazole Derivatives and Evaluation of Their Biological Activities

2019 ◽  
Vol 56 (4) ◽  
pp. 1318-1329 ◽  
Author(s):  
Srinivasa Rao Dasari ◽  
Subbaiah Tondepu ◽  
Lakshmana Rao Vadali ◽  
Nareshvarma Seelam
Keyword(s):  
Molecular Modeling ◽  
Biological Activities ◽  
Design Synthesis ◽  
Triazole Derivatives ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Synthesis and Anti-Inflammatory Activity of 3-Aryloxylindolizine Derivatives via Sonogashira Coupling/5-endo-trig Cycloisomerization Domino Strategy

2013 ◽  
Vol 781-784 ◽  
pp. 1093-1097 ◽  
Author(s):  
Yong Wei ◽  
Cheng Qiao Cao ◽  
Jian Feng Chen ◽  
Kun Zou ◽  
Zhang Shuang Deng ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Elemental Analysis ◽  
Biological Activities ◽  
Bacterial Lipopolysaccharide ◽  
Sonogashira Coupling ◽  
Propargyl Ether ◽  
Mouse Cells ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Stimulation Of

With the aim of obtaining potential IL-6 inhibitor for the treatment of rheumatoid arthritis, four 3-aryloxylindolizine derivatives were synthesized from the 2-bromopyridine and aryl propargyl ether through the Sonogashira coupling/5-endo-trigcycloisomerization domino strategy. These compounds were characterized by NMR, IR, EI-MS and elemental analysis. Their biological activities were evaluated by the bacterial lipopolysaccharide (LPS) stimulation of mouse cells on the RAW264.7 inflammation model. All the compounds revealed good anti-inflammatory activities with the inhibitions of 71~82% against IL-6 at 100 μM. The bioactive 3-aryloxylindolizines might be used as potential anti-inflammatory drugs.

scholarly journals Interaction of indomethacin with calf thymus DNA: a multi-spectroscopic, thermodynamic and molecular modelling approach

MedChemComm ◽  
2017 ◽  
Vol 8 (6) ◽  
pp. 1283-1296 ◽  
Author(s):  
Mohammed Amir Husain ◽  
Hassan Mubarak Ishqi ◽  
Tarique Sarwar ◽  
Sayeed Ur Rehman ◽  
Mohammad Tabish
Keyword(s):  
Acetic Acid ◽  
Acid Derivative ◽  
Molecular Modelling ◽  
Biological Activities ◽  
Calf Thymus Dna ◽  
Calf Thymus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Modelling Approach

Indomethacin belongs to the acetic acid derivative class of non-steroidal anti-inflammatory drugs with diverse pharmacological and biological activities.

scholarly journals Design, synthesis and biological evaluation of hybrid nitroxide-based non-steroidal anti-inflammatory drugs

2018 ◽  
Vol 147 ◽  
pp. 34-47 ◽  
Author(s):  
Komba Thomas ◽  
Terry W. Moody ◽  
Robert T. Jensen ◽  
Jason Tong ◽  
Cassie L. Rayner ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Synthesis And Biological Evaluation

Anti-neuropathic and anticonvulsant activities of various substituted triazoles analogues

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Review Article ◽  
Biological Profile ◽  
Triazole Derivatives ◽  
Anti Inflammatory ◽  
New Compounds ◽  
Anticonvulsant Activities

Various heterocyclic compounds along their derivatives were evaluated for their biological activities as antiviral, antitumor, anticonvulsant, antibacterial, antifungal, antituberculosis, analgesic, anti-inflammatory, antidiabetic, antihistamine and other biological activities. The triazole moiety seems to be very small, but in the biological profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. The triazole derivatives possess a great importance in medicinal chemistry and can be used for the synthesis of numerous heterocyclic compounds with different biological activities. This review article covers the information of triazoles derivatives having different psychopharmacological actions. Thus triazole acts as a promising medicinal agent for the scientists working over this field. This review can be helpful to develop various more new compounds possessing triazoles moiety that could be better in terms of efficacy and lesser toxicity.

Antiviral and antiparasitic activities of various substituted triazole derivatives: A mini review

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Biological Activities ◽  
Chemical Properties ◽  
Membered Ring ◽  
Ring Systems ◽  
Triazole Derivatives ◽  
Heterocyclic Derivatives ◽  
Interesting Class ◽  
Anti Inflammatory ◽  
And Chemical Properties

The presence of three nitrogen hetero-atoms in five-membered ring systems defines an interesting class of compounds, the triazole. This may be of two types, the 1,2,3-triazoles and the 1,2,4-triazoles. Out of the two triazoles, 1,2,4-triazole have drawn great attention due to its wide variety of activities, low toxicities and good pharmacokinetic and pharmacodynamic profiles. Chemistry of triazoles and their fused heterocyclic derivatives has received considerable attention owing to their effective biological activities such as anti inflammatory, analeptic, sedatives, antianxiety, antimicrobial, antimycotic and other pharmacological and chemical properties. In this article, antiviral and antiparasitic activities of triazole derivatives are discussed.

Sign in / Sign up

Export Citation Format

Share Document