MRI‐Based Deep‐Learning Model for Distant Metastasis‐Free Survival in Locoregionally Advanced Nasopharyngeal Carcinoma

2020 ◽  
Vol 53 (1) ◽  
pp. 167-178
Author(s):  
Lu Zhang ◽  
Xiangjun Wu ◽  
Jing Liu ◽  
Bin Zhang ◽  
Xiaokai Mo ◽  
...  
Keyword(s):  
Deep Learning ◽  
Nasopharyngeal Carcinoma ◽  
Distant Metastasis ◽  
Learning Model ◽  
Free Survival ◽  
Distant Metastasis Free Survival ◽  
Deep Learning Model

scholarly journals Clinical Study of Nasopharyngeal Carcinoma Treated by Helical Tomotherapy in China: 5-Year Outcomes

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Lei Du ◽  
Xin-Xin Zhang ◽  
Lin Ma ◽  
Lin-Chun Feng ◽  
Fang Li ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Overall Survival ◽  
Nasopharyngeal Carcinoma ◽  
Distant Metastasis ◽  
Helical Tomotherapy ◽  
Antibody Therapy ◽  
Monoclonal Antibody Therapy ◽  
Relapse Free Survival ◽  
Free Survival ◽  
Distant Metastasis Free Survival

Background.To evaluate the outcomes of nasopharyngeal carcinoma (NPC) patients treated with helical tomotherapy (HT).Methods.Between September 2007 and August 2012, 190 newly diagnosed NPC patients were treated with HT. Thirty-one patients were treated with radiation therapy as single modality, 129 with additional cisplatin-based chemotherapy with or without anti-EGFR monoclonal antibody therapy, and 30 with concurrent anti-EGFR monoclonal antibody therapy.Results.Acute radiation related side effects were mainly grade 1 or 2. Grade 3 and greater toxicities were rarely noted. The median followup was 32 (3–38) months. The local relapse-free survival (LRFS), nodal relapse-free survival (NRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were 96.1%, 98.2%, 92.0%, and 86.3%, respectively, at 3 years. Cox multivariate regression analysis showed that age and T stage were independent predictors for 3-year OS.Conclusions.Helical tomotherapy for NPC patients achieved excellent 3-year locoregional control, distant metastasis-free survival, and overall survival, with relatively minor acute and late toxicities. Age and T stage were the main prognosis factors.

scholarly journals Elevated Levels of TNF-α and Decreased Levels of CD68-Positive Macrophages in Primary Tumor Tissues Are Unfavorable for the Survival of Patients With Nasopharyngeal Carcinoma

2019 ◽  
Vol 18 ◽  
pp. 153303381987480 ◽  
Author(s):  
Yahui Yu ◽  
Liangru Ke ◽  
Wei-Xiong Xia ◽  
Yanqun Xiang ◽  
Xing Lv ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Necrosis Factor ◽  
Distant Metastasis ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Prognostic Models ◽  
Free Survival ◽  
Distant Metastasis Free Survival ◽  
Factor Α ◽  
Necrosis Factor

Due to the critical role of inflammation in nasopharyngeal carcinoma, we aim to investigate the correlation between nasopharyngeal carcinoma prognosis and the levels of tumor necrosis factor α and macrophages for the development of new prognostic models. The levels of tumor necrosis factor-α and CD68-positive macrophages were measured in 111 primary nasopharyngeal carcinoma specimens by immunohistochemistry. Kaplan-Meier analysis showed that, compared with nonelevated tumor necrosis factor-α levels, elevated tumor necrosis factor α levels were correlated with poorer 10-year distant metastasis-free survival (24.5% vs 5.2%, P = .004) and bone metastasis-free survival (17.0% vs 0.0%, P = .001). Multivariate analysis revealed that tumor necrosis factor α level was an independent prognostic factor for distant metastasis-free survival (hazard ratio = 16.765, P = .001), while the level of CD68-positive macrophages was a favorable independent prognostic factor for cancer-specific survival (hazard ratio = 0.481, P = .023) and disease-free survival (hazard ratio = 0.403, P = .010). Additionally, several prognostic models that considered tumor-node-metastasis stage alone or in combination with tumor necrosis factor α and/or CD68-positive macrophage levels were compared by receiver operating characteristic curve analysis. Interestingly, the T_score model, which considered the tumor necrosis factor α level alone, could better predict the distant metastasis-free survival and bone metastasis-free survival, whereas the MT model, which considered the combination of T stage and CD68-positive macrophage level, could better predict the cancer-specific survival and disease-free survival of patients with nasopharyngeal carcinoma. Elevated tumor necrosis factor-α levels and decreased CD68-positive macrophage levels in primary nasopharyngeal carcinoma tissues are unfavorable prognostic indicators in nasopharyngeal carcinoma. The T_score model or the MT model could be better prognostic models than those currently available for nasopharyngeal carcinoma and could be used to select high-risk patients and aid in the design of individualized immunotherapy.

scholarly journals Preoperative CT-based Deep Learning Model for Predicting Disease-Free Survival in Patients with Lung Adenocarcinomas

Radiology ◽  
2020 ◽  
Vol 296 (1) ◽  
pp. 216-224 ◽  
Author(s):  
Hyungjin Kim ◽  
Jin Mo Goo ◽  
Kyung Hee Lee ◽  
Young Tae Kim ◽  
Chang Min Park
Keyword(s):  
Deep Learning ◽  
Disease Free Survival ◽  
Learning Model ◽  
Free Survival ◽  
Preoperative Ct ◽  
Lung Adenocarcinomas ◽  
Deep Learning Model ◽  
Disease Free

scholarly journals Association of neutrophil-to-lymphocyte ratio, neutrophil count, and VEGF on metastasis in patients with nasopharyngeal carcinoma

2020 ◽  
Author(s):  
Xingming Ye ◽  
Tianzhu Lu ◽  
Wendong Bai ◽  
Jing Jia ◽  
Lin Wang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Neutrophil Count ◽  
Distant Metastasis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Vegf Expression ◽  
Free Survival ◽  
Lymphocyte Ratio ◽  
Distant Metastasis Free Survival ◽  
Stage Disease ◽  
N Stage

Abstract Background Systemic inflammatory responses have important roles in the development and progression of cancer, including the propensity for metastasis. A high neutrophil-to-lymphocyte ratio (NLR) is associated with poor prognosis in nasopharyngeal carcinoma (NPC), but the underlying mechanisms are not clear. Vascular endothelial growth factor (VEGF) has been reported to be involved in the recruitment of pro-angiogenic neutrophils in tumor metastasis progress. Therefore, we focused on the correlations among NLR, neutrophil count, and VEGF during metastasis and explored the reasons for changes of NLR in advanced NPC. Methods Consecutive patients who had been investigated with magnetic resonance imaging and irradiated with intensity-modulated radiotherapy(IMRT) from November 2011 to December 2012 were studied retrospectively. Clinical parameters (NLR, neutrophil count) were measured and their association with NPC stage advancement and VEGF were assessed using the Kruskal–Wallis test. Associations with patient survival were analyzed using the Kaplan–Meier method and log-rank test. Results NLR was elevated in advanced N stage (P < 0.0001) and M stage disease (P = 0.0034), but not T stage disease (P = 0.7049). Changes to the NLR in advanced N stage and M stage disease were affected most strongly by neutrophil count (P = 0.0074 and P = 0.0064, respectively) and higher NLR levels were associated with higher neutrophil count (P < 0.0001). NLR > 2.26 and positive VEGF expression (+++) correlated significantly with distant metastasis-free survival (P = 0.0340 and P = 0.0023, respectively). Neutrophil counts correlated positively with VEGF expression (P = 0.0024) in NPC tissue. Conclusion Our results demonstrate a positive correlation between NLR, neutrophil count, and VEGF expression in NPC. Higher NLR and VEGF expression are associated with distant metastasis-free survival among patients with NPC, which implies that they set a basis of immune activation in advanced nasopharyngeal carcinoma.

scholarly journals Diffusion-weighted MRI for predicting treatment response in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Min Kyoung Lee ◽  
Yangsean Choi ◽  
So-Lyung Jung
Keyword(s):  
Overall Survival ◽  
Nasopharyngeal Carcinoma ◽  
Treatment Response ◽  
Distant Metastasis ◽  
Meta Analysis ◽  
Local Relapse ◽  
Relapse Free Survival ◽  
Free Survival ◽  
Distant Metastasis Free Survival ◽  
Hazard Ratios

AbstractEarly prediction of treatment response in nasopharyngeal carcinoma is clinically relevant for optimizing treatment strategies. This meta-analysis was performed to evaluate whether apparent diffusion coefficient (ADC) from diffusion-weighted imaging (DWI) can predict treatment response of patients with nasopharyngeal carcinoma. A systematic search of PubMed-MEDLINE and Embase was performed to identify relevant original articles until July 22, 2021. We included studies which performed DWI for predicting locoregional treatment response in nasopharyngeal carcinoma treated with neoadjuvant chemotherapy, definitive chemoradiation, or radiation therapy. Hazard ratios were meta-analytically pooled using a random-effects model for the pooled estimates of overall survival, local relapse-free survival, distant metastasis-free survival and their 95% CIs. ADC showed a pooled sensitivity of 87% (95% CI 72–94%) and specificity of 70% (95% CI 56–80%) for predicting treatment response. Significant between-study heterogeneity was observed for both pooled sensitivity (I2 = 68.5%) and specificity (I2 = 92.2%) (P < 0.01). The pooled hazard ratios of low pretreatment ADC for assessing overall survival, local relapse-free survival, and distant metastasis-free survival were 1.42 (95% CI 1.09–1.85), 2.31 (95% CI 1.42–3.74), and 1.35 (95% CI 1.05–1.74), respectively. In patients with nasopharyngeal carcinoma, pretreatment ADC demonstrated good predictive performance for treatment response.

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