T2 Relaxometry Evidence of Microstructural Changes in Diffusely Abnormal White Matter in Relapsing–Remitting Multiple Sclerosis and Clinically Isolated Syndrome: Impact on Visuomotor Performance

2021 ◽  
Author(s):  
Efrosini Papadaki ◽  
Vasileios Mastorodemos ◽  
Theodora Panou ◽  
Styliani Pouli ◽  
Eirini Spyridaki ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Clinically Isolated Syndrome ◽  
T2 Relaxometry ◽  
Microstructural Changes ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Visuomotor Performance

Normal-appearing grey and white matter T1 abnormality in early relapsing–remitting multiple sclerosis: a longitudinal study

2007 ◽  
Vol 13 (2) ◽  
pp. 169-177 ◽  
Author(s):  
Gr Davies ◽  
A Hadjiprocopis ◽  
DR Altmann ◽  
Dt Chard ◽  
Cm Griffin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Peak Height ◽  
Therapeutic Monitoring ◽  
Fast Spin Echo ◽  
Proton Density ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

Objective To investigate the presence and evolution of T1 relaxation time abnormalities in normal-appearing white matter (NAWM) and grey matter (GM), early in the course of relapsing–remitting multiple sclerosis (MS). Methods Twenty-three patients with early relapsing–remitting MS and 14 healthy controls were imaged six monthly for up to three years. Mean follow-up was 26 months for MS patients and 24 months for controls. Dual-echo fast-spin echo and gradient-echo proton-density and T1-weighted data sets (permitting the calculation of a T1 map) were acquired in all subjects. GM and NAWM T1 histograms were produced and a hierarchical regression model was used to investigate changes in T1 over time. Results At baseline, significant patient-control differences were seen, both in NAWM (P = 0.001) and in GM (P = 0.01). At follow-up, there was no evidence for a serial change in either mean T1 or peak-location for either NAWM or GM. There was weak evidence for a decline in patient NAWM peak-height and also evidence for a decline in control GM peak-height. Conclusion There are significant and persistent abnormalities of NAWM and GM T1 in early relapsing-remitting MS. Further studies should address whether such T1 measures have a role in prognosis or therapeutic monitoring. Multiple Sclerosis 2007; 13:169–177. http://msj.sagepub.com

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