Abbreviated Gadoxetic Acid‐Enhanced MRI for the Detection of Liver Metastases in Patients With Potentially Resectable Pancreatic Ductal Adenocarcinoma

2022 ◽  
Author(s):  
Takeru Yamaguchi ◽  
Keitaro Sofue ◽  
Eisuke Ueshima ◽  
Yoshiko Ueno ◽  
Yushi Tsujita ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Gadoxetic Acid ◽  
Ductal Adenocarcinoma ◽  
Enhanced Mri

Hepatobiliary contrast uptake patterns on gadoxetic acid–enhanced MRI in liver metastases from pancreatic ductal adenocarcinoma: can it predict prognosis?

2020 ◽  
Vol 31 (1) ◽  
pp. 276-282
Author(s):  
Yoshifumi Noda ◽  
Toru Tochigi ◽  
Vinit Baliyan ◽  
Hamed Kordbacheh ◽  
Avinash Kambadakone
Keyword(s):  
Liver Metastases ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Gadoxetic Acid ◽  
Ductal Adenocarcinoma ◽  
Enhanced Mri

scholarly journals The Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response—Response

2021 ◽  
Vol 27 (14) ◽  
pp. 4127-4127
Author(s):  
Henry C.-H. Law ◽  
Emalie J. Clement ◽  
Paul M. Grandgenett ◽  
Michael A. Hollingsworth ◽  
Nicholas T. Woods
Keyword(s):  
Liver Metastases ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Clinical Response ◽  
Molecular Subtypes ◽  
Ductal Adenocarcinoma

scholarly journals Liver Metastases in Newly Diagnosed Pancreatic Ductal Adenocarcinoma: A Population Based Analysis

2020 ◽  
Author(s):  
Guoyi Wu ◽  
Xiaoben Pan ◽  
Baohua Wang ◽  
Xiaolei Zhu ◽  
Jing Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Metastases ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Tumor Size ◽  
Cox Regression ◽  
Population Based ◽  
The Body ◽  
Ductal Adenocarcinoma ◽  
Rank Test ◽  
Factors Associated

Abstract Background Estimates of the incidence and prognosis of developing liver metastases at the pancreatic ductal adenocarcinoma (PDAC) diagnosis are lacking.Methods In this study, we analyzed the association of liver metastases and the PDAC patients outcome. The risk factors associated with liver metastases in PDAC patients were analyzed using multivariable logistic regression analysis. The overall survival (OS) was estimated using Kaplan-Meier curves and log-rank test. Cox regression was performed to identify factors associated with OS.Results Patients with primary PDAC in the tail of the pancreas had a higher incidence of liver metastases (62.2%) than those with PDAC in the head (28.6%). Female gender, younger age, primary PDAC in the body or tail of the pancreas, and larger primary PDAC tumor size were positively associated with the occurrence of liver metastases. The median survival of patients with liver metastases was significantly shorter than that of patients without liver metastases. Older age, unmarried status, primary PDAC in the tail of the pancreas, and tumor size ≥4 cm were risk factors for OS in the liver metastases cohort.Conclusions Population-based estimates of the incidence and prognosis of PDAC with liver metastases may help decide whether diffusion-weighted magnetic resonance imaging should be performed in patients with primary PDAC in the tail or body of the pancreas. The location of primary PDAC should be considered during the diagnosis and treatment of primary PDAC.

scholarly journals Complete Response of Synchronous Liver Metastasis in a Pancreatic Ductal Adenocarcinoma, When Surgery Could Represent a Therapeutic Option

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Antonella Argentiero ◽  
Angela Calabrese ◽  
Angela Monica Sciacovelli ◽  
Sabina Delcuratolo ◽  
Antonio Giovanni Solimando ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Lung Metastases ◽  
Therapeutic Option ◽  
Disease Free Survival ◽  
Complete Response ◽  
Ductal Adenocarcinoma ◽  
Pancreatic Lesion ◽  
Link Type ◽  
Multiple Liver Metastases

Metastatic pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis and short survival. Today, the use of new polytherapeutic regimens increases clinical outcome of these patients opening new clinical scenario. A crucial issue related to the actual improvement achieved with these new regimens is represented by the occasional possibility to observe a radiological complete response of metastatic lesions in patients with synchronous primary tumor. What could be the best therapeutic management of these patients? Could surgery represent an indication? Herein, we reported a case of a patient with PDAC of the head with multiple liver metastases, who underwent first-line chemotherapy with mFOLFIRINOX. After 10 cycles, he achieved a complete radiological response of liver metastases and a partial response of pancreatic lesion. A duodenocephalopancreasectomy was performed. Due to liver a lung metastases after 8 months from surgery, a second-line therapy was started with a disease-free survival and overall survival of 8 months and 45 months, respectively. Improvement in the molecular characterization of PDAC could help in the selection of patients suitable for multimodal treatments. This trial is registered with NCT02892305 and NCT00855634.

scholarly journals The Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response

2019 ◽  
Vol 26 (5) ◽  
pp. 1065-1076 ◽  
Author(s):  
Henry C.-H. Law ◽  
Dragana Lagundžin ◽  
Emalie J. Clement ◽  
Fangfang Qiao ◽  
Zachary S. Wagner ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Clinical Response ◽  
Molecular Subtypes ◽  
Ductal Adenocarcinoma

scholarly journals Additional value of gadoxetic acid-enhanced MRI to conventional extracellular gadolinium-enhanced MRI for the surgical management of colorectal and neuroendocrine liver metastases

HPB ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. 710-715 ◽  
Author(s):  
Claudya Morin ◽  
Sebastien Drolet ◽  
Carl Daigle ◽  
Isabelle Deshaies ◽  
Jean-Francois Ouellet ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Surgical Management ◽  
Gadoxetic Acid ◽  
Enhanced Mri ◽  
Additional Value ◽  
Neuroendocrine Liver Metastases
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