Accurate mass measurement and tandem mass spectrometry of intact globin chains identify the low proportion variant hemoglobin Lepore–Boston–Washington from the blood of a heterozygote

2004 ◽  
Vol 39 (3) ◽  
pp. 289-294 ◽  
Author(s):  
Dilip K. Rai ◽  
Brian N. Green ◽  
Britta Landin ◽  
Gunvor Alvelius ◽  
William J. Griffiths



2005 ◽  
Vol 11 (1) ◽  
pp. 73-82 ◽  
Author(s):  
Christine Eckers ◽  
John J. Monaghan ◽  
Jean-Claude Wolff

This work describes electrospray ionisation tandem mass spectrometry studies of trimethoprim and a series of structurally similar compounds containing alkoxy-phenyl groups, using accurate mass measurement to confirm the proposed fragmentations. Radical cations were observed in the spectra obtained for some of the compounds, as well as uncommon fragmentations showing losses of CH4 and C2H6, whereas other compounds showed the formation of even electron ions. Possible structures for the fragment ions have been proposed and explanations for the different types of fragmentation based on the structures of the compounds. In addition an alternate structure for a fragment ion previously reported for tandem mass spectrometry of trimethoprim has been proposed, based on accurate mass measurement.



2002 ◽  
Vol 37 (4) ◽  
pp. 357-371 ◽  
Author(s):  
John M. Koomen ◽  
William K. Russell ◽  
Shane E. Tichy ◽  
David H. Russell




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