Studies on the prevalence of oncogenic HPV types among Lithuanian women with cervical pathology

ABSTRACTHuman papillomavirus (HPV) is the etiological agent for all cervical cancers, a significant number of other anogenital cancers, and a growing number of head and neck cancers. Two licensed vaccines offer protection against the most prevalent oncogenic types, 16 and 18, responsible for approximately 70% of cervical cancer cases worldwide and one of these also offers protection against types 6 and 11, responsible for 90% of genital warts. The vaccines are comprised of recombinantly expressed major capsid proteins that self-assemble into virus-like particles (VLPs) and prevent infection by eliciting neutralizing antibodies. Adding the other frequently identified oncogenic types 31, 33, 45, 52, and 58 to a vaccine would increase the coverage against HPV-induced cancers to approximately 90%. We describe the generation and characterization of panels of monoclonal antibodies to these five additional oncogenic HPV types, and the selection of antibody pairs that were high affinity and type specific and recognized conformation-dependent neutralizing epitopes. Such characteristics make these antibodies useful tools for monitoring the production and potency of a prototype vaccine as well as monitoring vaccine-induced immune responses in the clinic.

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Prophylaxis of Cervical Cancer and Related Cervical Disease: A Review of the Cost-Effectiveness of Vaccination Against Oncogenic HPV Types

Journal of Managed Care Pharmacy ◽

10.18553/jmcp.2010.16.3.217 ◽

2010 ◽

Vol 16 (3) ◽

pp. 217-230 ◽

Cited By ~ 38

Author(s):

Edward P. Armstrong

Keyword(s):

Cervical Cancer ◽

Cost Effectiveness ◽

Cervical Disease ◽

Hpv Types ◽

The Cost ◽

Oncogenic Hpv

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Risk of CIN3 or worse with persistence of 13 individual oncogenic HPV types

International Journal of Cancer ◽

10.1002/ijc.31883 ◽

2019 ◽

Vol 144 (8) ◽

pp. 1975-1982 ◽

Cited By ~ 10

Author(s):

Freja Lærke Sand ◽

Christian Munk ◽

Kirsten Frederiksen ◽

Jette Junge ◽

Thomas Iftner ◽

...

Keyword(s):

Hpv Types ◽

Oncogenic Hpv

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Prevalence of Oncogenic HPV Types in Sardinia (Italy): Implications for the Impact of Prophylactic Anti-HPV Vaccines

American Journal of Infectious Diseases ◽

10.3844/ajidsp.2007.134.141 ◽

2007 ◽

Vol 3 (3) ◽

pp. 134-141

Author(s):

Stefania Montisci ◽

Sabrina Pitzalis ◽

Marianna Greco ◽

Alberto Orani ◽

Marco Rais ◽

...

Keyword(s):

Hpv Vaccines ◽

Hpv Types ◽

The Impact ◽

Oncogenic Hpv

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Seroprevalences of Herpes Simplex Virus Type 2, Five Oncogenic Human Papillomaviruses, and Chlamydia trachomatis in Katowice, Poland

Clinical and Vaccine Immunology ◽

10.1128/cvi.00260-07 ◽

2008 ◽

Vol 15 (4) ◽

pp. 675-680 ◽

Cited By ~ 5

Author(s):

Staffan Görander ◽

Teresa Lagergård ◽

Malgorzata Romanik ◽

Raphael P. Viscidi ◽

Gayane Martirosian ◽

...

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Chlamydia Trachomatis ◽

Blood Donors ◽

Human Papillomaviruses ◽

Igg Antibodies ◽

Hpv Types ◽

Simplex Virus ◽

Oncogenic Hpv

ABSTRACT Herpes simplex virus type 2 (HSV-2), human papillomaviruses (HPVs), and Chlamydia trachomatis are the most common pathogens causing sexually transmitted infections (STIs). There is limited information about the prevalences of these STIs in Poland. Here, we estimated the occurrence of immunoglobulin G (IgG) antibodies against HSV-2, HPV, and C. trachomatis in 199 blood donors and 110 patients of both genders attending an STI clinic in Katowice in southern Poland. The seroprevalences of HSV-2 were 5% for blood donors and 14% in the STI cohort. The seroprevalences of the five potentially oncogenic HPV types 16, 18, 31, 35, and 51 were 15%, 7%, 5%, 5%, and 17%, respectively, in blood donors and 37%, 8%, 12%, 5%, and 21%, respectively, in the STI cohort. The majority of HPV-infected individuals showed antibodies against more than one type, i.e., had been infected with multiple HPV types. Anti-C. trachomatis IgG antibodies were detected in 6% of blood donors and 13% of individuals attending the STI clinic. The relatively high prevalence of HPV-51 may have implications for future vaccine programs, as the newly introduced HPV vaccines are based on the potentially oncogenic HPV types 16 and 18.

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Association of detection of aflatoxin in plasma of Kenyan women with increased detection of oncogenic HPV.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.5530 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. 5530-5530

Author(s):

Jianjun Zhiang ◽

Elkanah Omenge ◽

Titus Maina ◽

Kapten Muthoka ◽

Stephen Kiptoo ◽

...

Keyword(s):

Cervical Cancer ◽

Cervical Dysplasia ◽

Hpv Infection ◽

Immunosuppressive Agent ◽

Sub Saharan Africa ◽

Hpv Testing ◽

Hpv 16 ◽

Kenyan Women ◽

Hpv Types ◽

Oncogenic Hpv

5530 Background: Cervical cancer is the leading cause of cancer-related deaths among women living in Africa. Only a small proportion of HPV-infected women develop cervical cancer and other cofactors may increase a woman’s risk of developing cervical cancer. Aflatoxin, a potent carcinogen and immunosuppressive agent, is produced by fungi that contaminate corn and other staple foods in sub-Saharan Africa. Women who ingest aflatoxin may be more likely to have persistent infections with oncogenic HPV type. Methods: Demographics, behavioral data, plasma, and cervical swabs were collected from HIV-uninfected women 18 and 45 years of age who presented for cervical cancer screening at Moi Referral and Teaching Hospital (Eldoret, Kenya) and had normal VIA examination. HPV testing was performed on cervical swabs using the Roche Linear Array Assay. Aflatoxin-albumin adduct (AFB1-lys) was detected and quantified in plasma. The association of plasma AFB1-lys detection and concentration and the detection of HPV was examined. Results: Sufficient plasma was available from 88 HIV-uninfected women and was transported to the U.S. for aflatoxin testing. Valid HPV testing results were available for 86 of these women (mean age 34.0 years); 49 women (57.0%) had detectable AFB1-lys and 37 (43.0%) had no detection. Substantial variation existed in plasma AFB1-lys concentrations among the 49 women (range 0.02 to 0.21 pg/µL). Detection of AFB1-lys was not associated with age, and other behavioral factors such as number of lifetime partners, marital status and age at first sex. AFB1-lys detection was associated with detection of A9 HPV types (HPV 16, 31, 33, 35, 52, and 58) as a group in cervical swabs (p = 0.029) as well as A9 types excluding HPV 16 (p = 0.020), but not with individual A9 types, A7 HPV types (such as HPV 18), or low-risk HPV types. A concentration dependent association of AFB1-lys was seen with detection of A9 HPV types as a group (p = 0.009), non-HPV 16 A9 types (p = 0.005), and HPV 52 (p = 0.042), but not with the A7 HPV types. Conclusions: AFB1-lys was detected in 57% of HIV-uninfected Kenyan women without cervical dysplasia. AFB1-lys-positive women were more likely than AFB1-lys-negative women to have oncogenic HPV A9 types detected. Higher plasma AFB1-lys concentrations were associated with increased likelihood of oncogenic HPV A9 type detection. Further studies are needed to determine if chronic exposure to aflatoxin interacts with HPV infection (and possibly HIV co-infection) to modulate the risk of cervical cancer in women in Kenya and other developing countries.

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Comparison of MY09/11 consensus PCR and type-specific PCRs in the detection of oncogenic HPV types

Journal of Cellular and Molecular Medicine ◽

10.1111/j.1582-4934.2007.00073.x ◽

2007 ◽

Vol 11 (4) ◽

pp. 881-891 ◽

Cited By ~ 75

Author(s):

C. E. Depuydt ◽

G. A. V. Boulet ◽

C. A. J. Horvath ◽

I. H. Benoy ◽

A. J. Vereecken ◽

...

Keyword(s):

Hpv Types ◽

Oncogenic Hpv

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HPV Types 16, 18, 45 and 31: The Most Important Oncogenic HPV Types Worldwide

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2008.05.102 ◽

2008 ◽

Vol 12 ◽

pp. e23

Author(s):

F.X. Bosch

Keyword(s):

Hpv Types ◽

Oncogenic Hpv

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Vaginal microbiota and human papillomavirus infection among young Swedish women

npj Biofilms and Microbiomes ◽

10.1038/s41522-020-00146-8 ◽

2020 ◽

Vol 6 (1) ◽

Cited By ~ 1

Author(s):

Liqin Cheng ◽

Johanna Norenhag ◽

Yue O. O. Hu ◽

Nele Brusselaers ◽

Emma Fransson ◽

...

Keyword(s):

Human Papillomavirus ◽

Alpha Diversity ◽

Hpv Infection ◽

Cross Sectional Study ◽

Vaginal Microbiota ◽

Microbial Composition ◽

Cross Sectional ◽

Sexually Transmitted ◽

Hpv Types ◽

Oncogenic Hpv

Abstract Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. To define the HPV-associated microbial community among a high vaccination coverage population, we carried out a cross-sectional study with 345 young Swedish women. The microbial composition and its association with HPV infection, including 27 HPV types, were analyzed. Microbial alpha-diversity was found significantly higher in the HPV-infected group (especially with oncogenic HPV types and multiple HPV types), compared with the HPV negative group. The vaginal microbiota among HPV-infected women was characterized by a larger number of bacterial vaginosis-associated bacteria (BVAB), Sneathia, Prevotella, and Megasphaera. In addition, the correlation analysis demonstrated that twice as many women with non-Lactobacillus-dominant vaginal microbiota were infected with oncogenic HPV types, compared with L. crispatus-dominated vaginal microbiota. The data suggest that HPV infection, especially oncogenic HPV types, is strongly associated with a non-Lactobacillus-dominant vaginal microbiota, regardless of age and vaccination status.

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