Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury

Objective: to evaluate the performance of the quickSOFA scores and Systemic Inflammatory Response Syndrome as predictors of clinical outcomes in patients admitted to an emergency service. Method: a retrospective cohort study, involving adult clinical patients admitted to the emergency service. Analysis of the ROC curve was performed to assess the prognostic indexes between scores and outcomes of interest. Multivariate analysis used Poisson regression with robust variance, evaluating the relationship between variables with biological plausibility and outcomes. Results: 122 patients were selected, 58.2% developed sepsis. Of these, 44.3% had quickSOFA ≥2 points, 87% developed sepsis, 55.6% septic shock and 38.9% died. In the evaluation of Systemic Inflammatory Response Syndrome, 78.5% obtained results >2 points; of these, 66.3% developed sepsis, 40% septic shock and 29.5% died. quickSOFA ≥2 showed greater specificity for diagnosis of sepsis in 86% of the cases, for septic shock 70% and for mortality 64%, whereas the second score showed better results for sensitivity with diagnosis of sepsis in 87.5%, septic shock in 92.7% and death in 90.3%. Conclusion: quickSOFA showed by its practicality that it can be used clinically within the emergency services, bringing clinical applicability from the risk classification of patients for the early recognition of unfavorable outcomes.

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CEREBROPROTEIN HYDROLYSATE INDUCED SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS): A CASE REPORT

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i1.15138 ◽

2016 ◽

Vol 9 (1) ◽

pp. 321 ◽

Cited By ~ 1

Author(s):

Tarali Devi ◽

Subhash Sarma ◽

Urmi Choudhury

Keyword(s):

Traumatic Brain Injury ◽

Case Report ◽

Side Effects ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Therapeutic Agent ◽

Systemic Inflammatory Response ◽

Promising Therapeutic Agent

<p>Cerebroprotein hydrolysate is a newer pharmacological neurotropic agent and considered as a promising therapeutic agent for dementia, Alzheimer’s disease, traumatic brain injury and acute ischaemic stroke. Studies revealed that most of the side effects are minor. Here, we reported a case of Systemic inflammatory response syndrome (SIRS) probably due to use of Cerebroprotein hydrolysate in a patient with acute ischaemic stroke.</p>

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THE RELATIONSHIP OF PACKED CELL TRANSFUSION TO RED BLOOD CELL DEFORMABILITY IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROME PATIENTS

Shock ◽

10.1097/00024382-199802000-00002 ◽

1998 ◽

Vol 9 (2) ◽

pp. 84-88 ◽

Cited By ~ 21

Author(s):

Melanie H. Friedlander ◽

Ronald Simon ◽

George W. Machiedo

Keyword(s):

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Blood Cell ◽

Red Blood Cell ◽

Systemic Inflammatory Response ◽

Cell Deformability ◽

Red Blood Cell Deformability ◽

Packed Cell Transfusion ◽

Relationship Of ◽

The Relationship

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The relationship between intraoperative blood transfusion and postoperative systemic inflammatory response syndrome

The American Journal of Surgery ◽

10.1016/j.amjsurg.2012.07.042 ◽

2013 ◽

Vol 205 (4) ◽

pp. 457-465 ◽

Cited By ~ 21

Author(s):

Victor A. Ferraris ◽

Erik Q. Ballert ◽

Angela Mahan

Keyword(s):

Blood Transfusion ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Systemic Inflammatory Response ◽

The Relationship

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Upregulation of TLR2/4 Expression in Mononuclear Cells in Postoperative Systemic Inflammatory Response Syndrome after Liver Transplantation

Mediators of Inflammation ◽

10.1155/2010/519589 ◽

2010 ◽

Vol 2010 ◽

pp. 1-7 ◽

Cited By ~ 12

Author(s):

Ziqing Hei ◽

Xinjin Chi ◽

Nan Cheng ◽

Gangjian Luo ◽

Shangrong Li

Keyword(s):

Liver Transplantation ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Mononuclear Cells ◽

Perioperative Period ◽

Systemic Inflammatory Response ◽

Anhepatic Phase ◽

Induction Of Anaesthesia ◽

The Relationship ◽

Necrosis Factor

Background. To explore the relationship between Toll-like rpheral blood mononuclear cells (PBMC) and systemic inflammatory response syndrome (SIRS) in postoperative patients of liver transplantation (LT).Methods. Blood samples of 27 patients receiving LT were collected at T1 (after induction of anaesthesia), T2 (25 minutes after the beginning of anhepatic phase), T3 (3 hours after graft reperfusion), and T4 (24 hours after graft reperfusion). The expression of TLR2/4 on PBMC and serum concentration of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-8 were measured. The patients were divided into SIRS group (n=12) and non-SIRS group (n=15) for analysis.Results. Blood loss and transfusion were higher in the SIRS group than in the non-SIRS group. Both the preanhepatic and anhepatic phase were significantly longer in the SIRS group. The TLR2/4 expression on PBMC as well as serum TNF-α, IL-1β, and IL-8 were significantly higher at T3 and T4 than that at T1 and T2 in the SIRS patients. The expression of TLR4 on PBMC is positively correlated to serum TNF-α, IL-8. Expression of TLR2/4 on PBMC and serum concentrations of TNF-α, IL-1β, did not differ among the 4-time points in non-SIRS patients.Conclusions. Upregulation of TLR2/4 expression on PBMC may contribute to the development of postoperative SIRS during perioperative period of LT.

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Systemic inflammatory response syndrome, infection, and outcome in intracerebral hemorrhage

Neurology Neuroimmunology & Neuroinflammation ◽

10.1212/nxi.0000000000000428 ◽

2017 ◽

Vol 5 (2) ◽

pp. e428 ◽

Cited By ~ 6

Author(s):

Amelia K. Boehme ◽

Mary E. Comeau ◽

Carl D. Langefeld ◽

Aaron Lord ◽

Charles J. Moomaw ◽

...

Keyword(s):

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Intracerebral Hemorrhage ◽

Systemic Inflammatory Response ◽

Infection Age ◽

Racial Variations ◽

Poor Outcomes ◽

Ich Score ◽

The Relationship ◽

Admission Glasgow Coma Scale

Objective:Systemic inflammatory response syndrome (SIRS) may be related to poor outcomes after intracerebral hemorrhage (ICH).Methods:The Ethnic/Racial Variations of Intracerebral Hemorrhage study is an observational study of ICH in whites, blacks, and Hispanics throughout the United Sates. SIRS was defined by standard criteria as 2 or more of the following on admission: (1) body temperature <36°C or >38°C, (2) heart rate >90 beats per minute, (3) respiratory rate >20 breaths per minute, or (4) white blood cell count <4,000/mm3 or >12,000/mm3. The relationship among SIRS, infection, and poor outcome (modified Rankin Scale [mRS] 3–6) at discharge and 3 months was assessed.Results:Of 2,441 patients included, 343 (14%) met SIRS criteria at admission. Patients with SIRS were younger (58.2 vs 62.7 years; p < 0.0001) and more likely to have intraventricular hemorrhage (IVH; 53.6% vs 36.7%; p < 0.0001), higher admission hematoma volume (25.4 vs 17.5 mL; p < 0.0001), and lower admission Glasgow Coma Scale (GCS; 10.7 vs 13.1; p < 0.0001). SIRS on admission was significantly related to infections during hospitalization (adjusted odds ratio [OR] 1.36, 95% confidence interval [CI] 1.04–1.78). In unadjusted analyses, SIRS was associated with poor outcomes at discharge (OR 1.96, 95% CI 1.42–2.70) and 3 months (OR 1.75, 95% CI 1.35–2.33) after ICH. In analyses adjusted for infection, age, IVH, hematoma location, admission GCS, and premorbid mRS, SIRS was no longer associated with poor outcomes.Conclusions:SIRS on admission is associated with ICH score on admission and infection, but it was not an independent predictor of poor functional outcomes after ICH.

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