scholarly journals Quadriceps muscle volume positively contributes to ACL volume

2021 ◽  
Author(s):  
Sandra J. Shultz ◽  
Randy J. Schmitz ◽  
Anthony S. Kulas ◽  
Jeffrey D. Labban ◽  
Hsin‐Min Wang
Keyword(s):  
Quadriceps Muscle ◽  
Muscle Volume

Comparison of methods to assess quadriceps muscle volume using magnetic resonance imaging

2009 ◽  
Vol 30 (5) ◽  
pp. 1116-1123 ◽  
Author(s):  
Antoine Nordez ◽  
Erwan Jolivet ◽  
Ingrid Südhoff ◽  
Dominique Bonneau ◽  
Jacques A. de Guise ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Quadriceps Muscle ◽  
Muscle Volume ◽  
Comparison Of Methods ◽  
Resonance Imaging

scholarly journals Dietary protein intake does not modulate daily myofibrillar protein synthesis rates or loss of muscle mass and function during short-term immobilization in young men: a randomized controlled trial

2020 ◽  
Author(s):  
Sean Paul Kilroe ◽  
Jonathan Fulford ◽  
Sarah Jackman ◽  
Andrew Holwerda ◽  
Annemie Gijsen ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Dietary Protein ◽  
Protein Intake ◽  
Quadriceps Muscle ◽  
Myofibrillar Protein ◽  
Muscle Volume ◽  
Dietary Protein Intake ◽  
Short Term ◽  
Muscle Disuse ◽  
Myofibrillar Protein Synthesis

ABSTRACT Background Short-term (<1 wk) muscle disuse lowers daily myofibrillar protein synthesis (MyoPS) rates resulting in muscle mass loss. The understanding of how daily dietary protein intake influences such muscle deconditioning requires further investigation. Objectives To assess the influence of graded dietary protein intakes on daily MyoPS rates and the loss of muscle mass during 3 d of disuse. Methods Thirty-three healthy young men (aged 22 ± 1 y; BMI = 23 ± 1 kg/m2) initially consumed the same standardized diet for 5 d, providing 1.6 g protein/kg body mass/d. Thereafter, participants underwent a 3-d period of unilateral leg immobilization during which they were randomly assigned to 1 of 3 eucaloric diets containing relatively high, low, or no protein (HIGH: 1.6, LOW: 0.5, NO: 0.15 g protein/kg/d; n = 11 per group). One day prior to immobilization participants ingested 400 mL deuterated water (D2O) with 50-mL doses consumed daily thereafter. Prior to and immediately after immobilization upper leg bilateral MRI scans and vastus lateralis muscle biopsies were performed to measure quadriceps muscle volume and daily MyoPS rates, respectively. Results Quadriceps muscle volume of the control legs remained unchanged throughout the experiment (P > 0.05). Immobilization led to 2.3 ± 0.4%, 2.7 ± 0.2%, and 2.0 ± 0.4% decreases in quadriceps muscle volume (P < 0.05) of the immobilized leg in the HIGH, LOW, and NO groups (P < 0.05), respectively, with no significant differences between groups (P > 0.05). D2O ingestion resulted in comparable plasma free [2H]-alanine enrichments during immobilization (∼2.5 mole percentage excess) across groups (P > 0.05). Daily MyoPS rates during immobilization were 30 ± 2% (HIGH), 26 ± 3% (LOW), and 27 ± 2% (NO) lower in the immobilized compared with the control leg, with no significant differences between groups (P > 0.05). Conclusions Three days of muscle disuse induces considerable declines in muscle mass and daily MyoPS rates. However, daily protein intake does not modulate any of these muscle deconditioning responses. Clinical trial registry number: NCT03797781

scholarly journals Automated assessment of regional muscle volume and hypertrophy using MRI

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mirko Mandić ◽  
Eric Rullman ◽  
Per Widholm ◽  
Mats Lilja ◽  
Olof Dahlqvist Leinhard ◽  
...  
Keyword(s):  
Knee Extensor ◽  
Quadriceps Muscle ◽  
Muscle Volume ◽  
Manual Segmentation ◽  
Automated Method ◽  
Fully Automatic ◽  
Automated Technique ◽  
Exercise Induced ◽  
Clinical Conditions ◽  
Regional Muscle

AbstractThis study aimed to validate a fully automatic method to quantify knee-extensor muscle volume and exercise-induced hypertrophy. By using a magnetic resonance imaging-based fat-water separated two-point Dixon sequence, the agreement between automated and manual segmentation of a specific ~15-cm region (partial volume) of the quadriceps muscle was assessed. We then explored the sensitivity of the automated technique to detect changes in both complete and partial quadriceps volume in response to 8 weeks of resistance training in 26 healthy men and women. There was a very strong correlation (r = 0.98, P < 0.0001) between the manual and automated method for assessing partial quadriceps volume, yet the volume was 9.6% greater with automated compared with manual analysis (P < 0.0001, 95% limits of agreement −93.3 ± 137.8 cm3). Partial muscle volume showed a 6.0 ± 5.0% (manual) and 4.8 ± 8.3% (automated) increase with training (P < 0.0001). Similarly, the complete quadriceps increased 5.1 ± 5.5% with training (P < 0.0001). The intramuscular fat proportion decreased (P < 0.001) from 4.1% to 3.9% after training. In conclusion, the automated method showed excellent correlation with manual segmentation and could detect clinically relevant magnitudes of exercise-induced muscle hypertrophy. This method could have broad application to accurately measure muscle mass in sports or to monitor clinical conditions associated with muscle wasting and fat infiltration.

scholarly journals Damaging eccentric exercise attenuates disuse induced declines in daily myofibrillar protein synthesis and transiently prevents muscle atrophy in healthy men.

2021 ◽  
Author(s):  
Tom S. O. Jameson ◽  
Sean P Kilroe ◽  
Jonathan Fulford ◽  
Doaa Reda Abdelrahman ◽  
Andrew John Murton ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Eccentric Exercise ◽  
Vastus Lateralis ◽  
Quadriceps Muscle ◽  
Quadriceps Strength ◽  
Myofibrillar Protein ◽  
Muscle Volume ◽  
Vastus Lateralis Muscle ◽  
Deuterated Water ◽  
Myofibrillar Protein Synthesis

Introduction: Short-term disuse leads to muscle loss driven by lowered daily myofibrillar protein synthesis (MyoPS). However, disuse commonly results from muscle damage, and its influence on muscle deconditioning during disuse is unknown. Methods: 21 males (20±1 y, BMI=24±1 kg·m-2 (±SEM)) underwent 7 days of unilateral leg immobilization immediately preceded by 300 bilateral, maximal, muscle-damaging eccentric quadriceps contractions (DAM; n=10) or no exercise (CON; n=11). Participants ingested deuterated water and underwent temporal bilateral thigh MRI scans and vastus lateralis muscle biopsies of immobilized (IMM) and non-immobilized (N-IMM) legs. Results: N-IMM quadriceps muscle volume remained unchanged throughout in both groups. IMM quadriceps muscle volume declined after 2 days by 1.7±0.5% in CON (P=0.031; and by 1.3±0.6% when corrected to N-IMM; P=0.06) but did not change in DAM, and declined equivalently in CON (by 6.4±1.1% [5.0±1.6% when corrected to N-IMM]) and DAM (by 2.6±1.8% [4.0±1.9% when corrected to N-IMM]) after 7 days. Immobilization began to decrease MyoPS compared with N-IMM in both groups after 2 days (P=0.109), albeit with higher MyoPS rates in DAM compared with CON (P=0.035). Frank suppression of MyoPS was observed between days 2-7 in CON (IMM=1.04±0.12, N-IMM=1.86±0.10%·d-1; P=0.002) but not DAM (IMM=1.49±0.29, N-IMM=1.90±0.30%·d-1; P>0.05). Declines in MyoPS and quadriceps volume after 7 days correlated positively in CON (R2=0.403; P=0.035) but negatively in DAM (R2=0.483; P=0.037). Quadriceps strength declined following immobilization in both groups, but to a greater extent in DAM. Conclusion: Prior muscle damaging eccentric exercise increases MyoPS and prevents loss of quadriceps muscle volume after 2 (but not 7) days of disuse.

scholarly journals Muscle Atrophy and Functional Deficits of Knee Extensors and Flexors in People With Chronic Stroke

2012 ◽  
Vol 92 (3) ◽  
pp. 429-439 ◽  
Author(s):  
Christiane L. Prado-Medeiros ◽  
Milla P. Silva ◽  
Giovanna C. Lessi ◽  
Marcela Z. Alves ◽  
Alberto Tannus ◽  
...  
Keyword(s):  
Motor Function ◽  
Muscle Atrophy ◽  
Peak Torque ◽  
Quadriceps Muscle ◽  
Chronic Stroke ◽  
Muscle Volume ◽  
Knee Extensors ◽  
Control Group ◽  
Hamstring Muscle ◽  
Paretic Limb

BackgroundFurther clarification is needed with regard to the degree of atrophy in individual muscle groups and its possible relationship to joint torque deficit poststroke.ObjectiveThe purpose of this study was to investigate quadriceps and hamstring muscle volume and strength deficits of the knee extensors and flexors in people with chronic hemiparesis compared with a control group.DesignThis was a cross-sectional study.MethodsThirteen individuals with hemiparesis due to chronic stroke (hemiparetic group) and 13 individuals who were healthy (control group) participated in this study. Motor function, quadriceps and hamstring muscle volume, and maximal concentric and eccentric contractions of the knee extensors and flexors were assessed.ResultsOnly the quadriceps muscle of the paretic limb showed reduced muscle volume (24%) compared with the contralateral (nonparetic) limb. There were no differences in muscle volume between the hemiparetic and control groups. The peak torque of the paretic-limb knee extensors and flexors was reduced in both contraction modes and velocities compared with the nonparetic limb (36%–67%) and with the control group (49%–75%). The nonparetic limb also showed decreased extensor and flexor peak torque compared with the control group (17%–23%). Power showed similar deficits in strength (12%–78%). There were significant correlations between motor function and strength deficits (.54–.67).LimitationsMagnetic resonance imaging coil length did not allow measurement of the proximal region of the thigh.ConclusionsThere were different responses between quadriceps and hamstring muscle volumes in the paretic limb that had quadriceps muscle atrophy only. However, both paretic and nonparetic limbs showed knee extensor and flexor torque and power reduction.

Relationship between muscle volume and contractile properties of the human knee extensors

2016 ◽  
Vol 41 (1) ◽  
pp. 110-113 ◽  
Author(s):  
Martin Behrens ◽  
Niklas Brown ◽  
Robert Bollinger ◽  
Dieter Bubeck ◽  
Anett Mau-Moeller ◽  
...  
Keyword(s):  
Knee Flexion ◽  
Femoral Nerve ◽  
Quadriceps Muscle ◽  
Muscle Volume ◽  
Contractile Properties ◽  
Knee Extensors ◽  
Resonance Imaging ◽  
Human Knee ◽  
The Relationship ◽  
Stimulation Of

The present study was designed to investigate the relationship between volume and electrically evoked twitch properties of the quadriceps muscle. Supramaximal single and doublet stimulation of the femoral nerve was used to assess contractile properties at 45° and 80° knee flexion. Muscle volume was measured using a 1.5-Tesla magnetic resonance imaging scanner. Quadriceps muscle volume was only significantly correlated (r = 0.629) with peak twitch torque induced by doublet stimulation at 80° but not at 45° knee flexion.

A More Efficient Magnetic Resonance Imaging???Based Strategy for Measuring Quadriceps Muscle Volume

2003 ◽  
Vol 35 (3) ◽  
pp. 425-433 ◽  
Author(s):  
BRIAN L. TRACY ◽  
FRED M. IVEY ◽  
E. JEFFREY METTER ◽  
JEROME L. FLEG ◽  
ELIOT L. SIEGEL ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Quadriceps Muscle ◽  
Muscle Volume ◽  
Resonance Imaging

scholarly journals Body composition skeletal muscle analysis in cancer cachexia studies: Is there a place for 3T MRI analysis?

2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Elaine Sandra Rogers ◽  
William Ormiston ◽  
Rachel Heron ◽  
Beau Pontré ◽  
Roderick MacLeod ◽  
...  
Keyword(s):  
Resistance Training ◽  
Cancer Cachexia ◽  
Essential Amino Acids ◽  
Quadriceps Muscle ◽  
Muscle Volume ◽  
Percentage Change ◽  
Volume Percentage ◽  
3T Mri ◽  
Cox 2 ◽  
End Stage

Background: Cancer cachexia is a condition often seen in end stage Non-Small Cell Lung Cancer (NSCLC) patients. Recent developments include the use of pharmaceutical agents and/or exercise to induce stability/hypertrophy of muscle volume. This requires accurate assessment of the change in both quantity and quality of the muscle during cancer cachexia clinical studies. 3T Magnetic Resonance Imaging (MRI) is appropriately placed to address both of these factors. Methods: Auckland’s Cancer Cachexia evaluating Resistance Training (ACCeRT) study is a randomised controlled feasibility study investigating eicosapentaenoic acid (EPA) and cyclo-oxygenase-2 (COX-2) inhibitor (celebrex) (Arm A) versus EPA, COX-2 inhibitor (celebrex), Progressive Resistance Training (PRT) plus essential amino acids (EAAs) high in leucine (Arm B) in NSCLC cachectic patients. All participants underwent 3T MRI scanning at baseline and at last or end of trial (EOT) visit.Results: Analysis showed a mean total quadriceps muscle volume percentage change from baseline to EOT of +12.47% (Arm A), compared with -2.96% (Arm B). There was a difference in muscle volume between genders. Arm B participant data showed a percentage change of +4.23% within females (n=2) compared with ˗10.15% (n=2) within males at EOT visit. All EOT results suggests the use of EPA and celecoxib +/- PRT and EAAs could potentially preserve muscle volume loss during refractory cachexia.Conclusion: ACCeRT is the first study to utilise 3T MRI total quadriceps muscle volume within a cancer cachexia study, along with the first in an end-stage/refractory cachexia population. These results can be used for baseline/reference for future cancer cachexia studies targeting the anabolic muscle pathways in end˗stage/refractory cachexia patients.

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