Optimisation of Drug Delivery 2. Principles of Drug Delivery and Limitations of Conventional Non-Oral Dosage Forms

1997 ◽  
Vol 27 (4) ◽  
pp. 313-320
Author(s):  
Heather AE Benson ◽  
Richard J Prankerd
Keyword(s):  
Drug Delivery ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Oral Dosage Forms

scholarly journals Hot-melt extrusion and prilling as contemporary and promising techniques in the solvent free production of solid oral dosage forms, based on solid dispersions

2016 ◽  
Vol 62 (1) ◽  
pp. 3-24 ◽  
Author(s):  
Aleksandar Aleksovski ◽  
Chris Vervaet ◽  
Rok Dreu
Keyword(s):  
Drug Delivery ◽  
Hot Melt Extrusion ◽  
Dosage Forms ◽  
Solvent Free ◽  
Oral Dosage ◽  
Drug Dissolution ◽  
Melt Extrusion ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms ◽  
Hot Melt

Hot melt extrusion and prilling are gaining importance as solvent free and continuous techniques in the production of solid oral dosage forms with added value, by incorporating active compound in a molten carrier which is further solidified to form solid dispersion. This article reviews these two techniques in terms of understanding process basics, equipment characteristics, required properties of processed materials and application of the processes for development of solid oral dosage forms. Studies revealed that both hot-melt extrusion and prilling are regarded as simple, robust and continuous methods for processing different types of materials and production of solid dosage forms based on solid matrices. However, understanding of their concepts and requirements together with careful material selection is crucial for stable material processing and obtaining stable products of high-quality. Hot-melt extrusion proved to be a suitable method for production of modified release dosage forms, taste masked dosage forms and dosage forms offering improved drug dissolution rate and solubility. Prilling till now has been successfully applied just in the production of multiple unit drug delivery systems for immediate and sustained drug delivery. Further studies on product development and process understanding are required for full implementation of prilling in the pharmaceutical field.

scholarly journals Fast dissolving tablets: waterless patient compliance dosage forms

2019 ◽  
Vol 9 (1) ◽  
pp. 303-317
Author(s):  
SANTOSH KUMAR RADA ◽  
Annu Kumari
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Oral Route ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Oral Drug ◽  
Self Medication ◽  
Existing Problems ◽  
Solid Dosage ◽  
Oral Dosage Forms

Drug delivery by the oral route is the most prescribable and acceptable route in terms of patient’s compliance. Improvement of patient’s compliance has always a challenge towards the development of oral drug delivery system. In the market different types of oral dosage forms are available in which tablets, capsules, syrups, suspensions are preferred ones. Oral solid drug delivery faces drawback in case of swallowing especially with paediatrics and geriatric psychotic patients. Therefore scientists attracted towards fast mouth dissolving drug delivery systems to encounter existing problems with unique property of palatability and rapid disintegration. The concept of fast dissolving tablet came into existence in late 1970 and further improvements are still going on in connection with its preparation and methodology. Fast dissolving tablets have faster disintegration and dissolution rate and releases within 30 seconds as they come in contact with saliva. These systems also obviate the requirement of carry water during drug administration. This facilitate drug delivery to the patients of dysphasic, psychic, paediatrics, geriatric and bed-ridden, unconscious population. As fast dissolving tablets falls under desired expectation of safer, convenient and economical solid dosage forms, several techniques have been developed to improve disintegration quality in the recent past years. This article mainly focuses on formulation and evaluation technologies with recent advancement made so far in the field of fast dissolving tablets. Keywords: Fast disintegration; Dysphasia; Mouth dissolving; Self-medication.

Patent Perspective on Orodispersible Films

2020 ◽  
Vol 14 (2) ◽  
pp. 88-97 ◽  
Author(s):  
Suresh Gupta ◽  
Tegginamath Pramod Kumar ◽  
Devegowda Vishakante Gowda
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Dosage Forms ◽  
Review Article ◽  
New Drugs ◽  
Oral Dosage ◽  
Orodispersible Films ◽  
The Cost ◽  
Oral Dosage Forms ◽  
Novel Drug

: The traditional oral dosage forms (tablets, capsules, syrups, and elixirs) suffer from various disadvantages. They are pretty challenging to administer to patients with dysphagia, mucositis, and vomiting tendency. Therefore, gaining patient compliance using conventional dosage forms is highly cumbersome. One of the most transformative and innovative approaches to overcome such challenges is Orodispersible Films, a Novel Drug Delivery System. They are easy to consume, no need to chew or swallow and they do not even require water for consumption. Therefore, several drugs have been converted into orodispersible films to gain patient compliance. With the advent of these film formulations, new innovations are erupting and accordingly, companies in India are actively protecting them by filing ordinary patent applications in India and internationally under the Patent Cooperation Treaty. Patenting in India poses unique patentability challenges when compared with rest of the world. Nonetheless, meeting all the challenges and obtaining a valid patent not only help in recouping the cost involved in developing new drugs and its novel drug delivery systems but also helps in taking legal action against alleged infringers. This review article identifies key active Indian players in the domain of ODF based on their patent filings in India (and abroad) and also identifies the challenges they face to obtain a grant.

Sign in / Sign up

Export Citation Format

Share Document