Complement: A Host Defense Mechanism Ready for Pharmacological Manipulation?

1977 ◽  
Vol 66 (10) ◽  
pp. 1367-1377 ◽  
Author(s):  
Brian J. Johnson
Keyword(s):  
Host Defense ◽  
Defense Mechanism ◽  
Pharmacological Manipulation ◽  
Host Defense Mechanism

Alterations of the Host Defense Mechanism in Burned Patients

1987 ◽  
Vol 67 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Kevin Moran ◽  
Andrew M. Munster
Keyword(s):  
Host Defense ◽  
Defense Mechanism ◽  
Host Defense Mechanism

scholarly journals Human Serum Albumin Is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication

2018 ◽  
Vol 218 (9) ◽  
pp. 1424-1435 ◽  
Author(s):  
Alessandra di Masi ◽  
Loris Leboffe ◽  
Fabio Polticelli ◽  
Federica Tonon ◽  
Cristina Zennaro ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Host Defense ◽  
Defense Mechanism ◽  
Essential Component ◽  
Host Defense Mechanism

scholarly journals Autophagy-activating strategies to promote innate defense against mycobacteria

2019 ◽  
Vol 51 (12) ◽  
pp. 1-10 ◽  
Author(s):  
Yi Sak Kim ◽  
Prashanta Silwal ◽  
Soo Yeon Kim ◽  
Tamotsu Yoshimori ◽  
Eun-Kyeong Jo
Keyword(s):  
Host Defense ◽  
Defense Mechanism ◽  
Multidrug Resistant ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Innate Defense ◽  
Host Defense Mechanism ◽  
A Cell

AbstractMycobacterium tuberculosis (Mtb) is a major causal pathogen of human tuberculosis (TB), which is a serious health burden worldwide. The demand for the development of an innovative therapeutic strategy to treat TB is high due to drug-resistant forms of TB. Autophagy is a cell-autonomous host defense mechanism by which intracytoplasmic cargos can be delivered and then destroyed in lysosomes. Previous studies have reported that autophagy-activating agents and small molecules may be beneficial in restricting intracellular Mtb infection, even with multidrug-resistant Mtb strains. Recent studies have revealed the essential roles of host nuclear receptors (NRs) in the activation of the host defense through antibacterial autophagy against Mtb infection. In particular, we discuss the function of estrogen-related receptor (ERR) α and peroxisome proliferator-activated receptor (PPAR) α in autophagy regulation to improve host defenses against Mtb infection. Despite promising findings relating to the antitubercular effects of various agents, our understanding of the molecular mechanism by which autophagy-activating agents suppress intracellular Mtb in vitro and in vivo is lacking. An improved understanding of the antibacterial autophagic mechanisms in the innate host defense will eventually lead to the development of new therapeutic strategies for human TB.

Pathogenesis of thrombosis

Hematology ◽  
2009 ◽  
Vol 2009 (1) ◽  
pp. 255-258 ◽  
Author(s):  
Bruce Furie
Keyword(s):  
High Pressure ◽  
Host Defense ◽  
Intravital Microscopy ◽  
Defense Mechanism ◽  
Tissue Injury ◽  
Thrombus Formation ◽  
Animal Experiments ◽  
Circulatory System ◽  
Live Animal ◽  
Host Defense Mechanism

Abstract The hemostatic process is a host defense mechanism to preserve the integrity of the closed high pressure circulatory system. This process must remain inactive but poised to minimize extravasation of blood from the vasculature following tissue injury. Given the complexity of the hemostatic mechanism, paradigms developed from biochemical and cell biological approaches have been revisited by studying thrombus formation in a live animal by intravital microscopy. Many of these paradigms have proven accurate, but others need to be reconsidered given the results of whole animal experiments.

Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori

2003 ◽  
Vol 125 (6) ◽  
pp. 1613-1625 ◽  
Author(s):  
Koji Hase ◽  
Masamoto Murakami ◽  
Mitsutoshi Iimura ◽  
Sheri P Cole ◽  
Yoshimune Horibe ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Host Defense ◽  
Defense Mechanism ◽  
Gastric Epithelial Cells ◽  
Potential Host ◽  
Host Defense Mechanism
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