Inhibitory mechanism of lactoferrin on antibacterial activity of oenothein B: isothermal titration calorimetry and computational docking simulation

2020 ◽  
Vol 100 (6) ◽  
pp. 2494-2501 ◽  
Author(s):  
Lichao Zhao ◽  
Aidi Zhou ◽  
Zitao Liu ◽  
Jian Xiao ◽  
Yu Wang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Isothermal Titration Calorimetry ◽  
Docking Simulation ◽  
Titration Calorimetry ◽  
Inhibitory Mechanism ◽  
Computational Docking ◽  
Oenothein B

Investigation on the Interaction Behavior Between Oenothein B and Pepsin by Isothermal Titration Calorimetry and Spectral Studies

2019 ◽  
Vol 84 (9) ◽  
pp. 2412-2420
Author(s):  
Zitao Liu ◽  
Li Wang ◽  
Lei Shi ◽  
Xun Chen ◽  
Yanlei Chang ◽  
...  
Keyword(s):  
Isothermal Titration Calorimetry ◽  
Spectral Studies ◽  
Titration Calorimetry ◽  
Interaction Behavior ◽  
Oenothein B

Investigation on the inactivation of trypsin by oenothein B: isothermal titration calorimetry and docking studies

2019 ◽  
Vol 55 (3) ◽  
pp. 1351-1358
Author(s):  
Li Wang ◽  
Huijun Liang ◽  
Zitao Liu ◽  
Jingfeng Zhang ◽  
Yu Wang ◽  
...  
Keyword(s):  
Isothermal Titration Calorimetry ◽  
Docking Studies ◽  
Titration Calorimetry ◽  
Oenothein B

Active site-targeted carbon dots for the inhibition of human insulin fibrillation

2017 ◽  
Vol 5 (10) ◽  
pp. 2010-2018 ◽  
Author(s):  
Q. Q. Yang ◽  
J. C. Jin ◽  
Z. Q. Xu ◽  
J. Q. Zhang ◽  
B. B. Wang ◽  
...  
Keyword(s):  
Isothermal Titration Calorimetry ◽  
Human Insulin ◽  
Active Site ◽  
Carbon Dots ◽  
Titration Calorimetry ◽  
Inhibitory Mechanism

This work aimed to study the inhibitory mechanism of carbon dots for HI fibrillation using isothermal titration calorimetry.

scholarly journals Evaluation of affinity of bioactive isolates from various coffee extracts through binding with PPAR-γ with the use of isothermal titration calorimetry and docking simulation to prevent antidiabetic effects

2020 ◽  
Vol 142 (2) ◽  
pp. 877-887
Author(s):  
Joanna Grzelczyk ◽  
Grażyna Budryn ◽  
Horacio Pérez-Sánchez
Keyword(s):  
Isothermal Titration Calorimetry ◽  
Green Light ◽  
Docking Simulation ◽  
Titration Calorimetry ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Molecular Docking Simulation ◽  
Ppar Γ ◽  
Tissue Sensitivity

Abstract Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a major receptor responsible for the pathogenesis of type 2 diabetes mellitus (T2DM). Deficiency in the human body of ligands binding to PPAR-γ causes the disorder of expression of many genes in adipose tissue and contributes to reducing tissue sensitivity to insulin, making it difficult to maintain glucose homeostasis, which consequently leads to T2DM. Therefore, natural non-toxic PPAR-γ ligands are sought. The aim of the research was to assess the affinity of single hydroxycinnamic or chlorogenic acids, coffee extracts and bioactive isolates from various coffee extracts of green, light and dark roasted Arabica and Robusta for PPAR-γ. This allows determining what type of coffee extract or its fraction can be used for therapy of T2DM. The research was carried out by means of isothermal titration calorimetry and molecular docking simulation. The studies have shown that caffeine and dihydrocaffeic acid had the highest affinity for PPAR-γ, which amounted ΔG = − 39.46 kJ mol−1 and − 33.60 kJ mol−1, respectively.

scholarly journals Enzymatic degradation of polyethylene terephthalate nanoplastics analyzed in real time by isothermal titration calorimetry

2021 ◽  
Vol 773 ◽  
pp. 145111
Author(s):  
Kristina Vogel ◽  
Ren Wei ◽  
Lara Pfaff ◽  
Daniel Breite ◽  
Hassan Al-Fathi ◽  
...  
Keyword(s):  
Real Time ◽  
Polyethylene Terephthalate ◽  
Isothermal Titration Calorimetry ◽  
Enzymatic Degradation ◽  
Titration Calorimetry
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