High‐level expression of PRSS3 correlates with metastasis and poor prognosis in patients with gastric cancer

2019 ◽  
Vol 119 (8) ◽  
pp. 1108-1121 ◽  
Author(s):  
Fei Wang ◽  
Yi‐Lin Hu ◽  
Ying Feng ◽  
Yi‐Bing Guo ◽  
Yi‐Fei Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
High Level Expression ◽  
High Level

High-Level Expression of S100A4 Correlates with Lymph Node Metastasis and Poor Prognosis in Patients with Gastric Cancer

2009 ◽  
Vol 17 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Yuan-Yu Wang ◽  
Zai-Yuan Ye ◽  
Zhong-Sheng Zhao ◽  
Hou-Quan Tao ◽  
Yong-Quan Chu
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Poor Prognosis ◽  
High Level Expression ◽  
Node Metastasis ◽  
High Level

High level of TXNDC9 predicts poor prognosis and contributes to the NF-κB-regulated metastatic potential in gastric cancer

Neoplasma ◽  
2021 ◽  
Author(s):  
Qun-Cao Yang ◽  
Nan Hao ◽  
Rui-Hua Li ◽  
Yuan-Yuan Duan ◽  
Yong Zhang
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level

scholarly journals High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (29) ◽  
pp. 46042-46055 ◽  
Author(s):  
Chao Li ◽  
Jian Chen ◽  
Yupeng Wang ◽  
Guohe Song ◽  
Chao Xiao ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level Expression ◽  
High Level

scholarly journals Correction: High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (27) ◽  
pp. 45031-45031 ◽  
Author(s):  
Chao Li ◽  
Jian Chen ◽  
Yupeng Wang ◽  
Guohe Song ◽  
Chao Xiao ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level Expression ◽  
High Level

High-level expression of periostin is closely related to metastatic potential and poor prognosis of hepatocellular carcinoma

2012 ◽  
Vol 30 (1) ◽  
Author(s):  
Yang Lv ◽  
Wei Wang ◽  
Wei-Dong Jia ◽  
Qi-Kai Sun ◽  
Jian-Sheng Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level Expression ◽  
High Level

scholarly journals Correlation of Altered Expression of the Autophagy Marker LC3B with Poor Prognosis in Astrocytoma

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Daniel Winardi ◽  
Hung-Pei Tsai ◽  
Chee-Yin Chai ◽  
Chia-Li Chung ◽  
Joon-Khim Loh ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Poor Prognosis ◽  
Beclin 1 ◽  
High Level Expression ◽  
Altered Expression ◽  
Protein Expressions ◽  
Weak Expression ◽  
High Level ◽  
The Relationship ◽  
Resistance To Chemotherapy

Glioblastoma multiforme is one of the most serious malignant brain tumors and is characterized by resistance to chemotherapy and radiation therapy. Recent studies suggest that autophagy may play an important role not only in the regulation of cancer development and progression but also in determining the response of cancer cells to anticancer therapy. The purpose of the present study was to assess the relationship between protein expressions of two autophagy markers, LC3B and Beclin-1, with clinical parameters in astrocytoma patients. Furthermore, the expression of CD133, a marker of the cancer stem-like cells, in astrocytoma patients was also investigated. A total of 106 thin-section slides were retrospectively collected from astrocytoma patients. LC3B, but not Beclin-1, protein expression was found to significantly correlate with resistance to radiation- or chemotherapy. In addition, high intensity of LC3B staining was predictive of poor prognosis. Furthermore, survival time of patients with high-level expression in both CD133 and LC3B was significantly shorter than those with weak expression in both CD133 and LC3B. These results suggest that astrocytoma cancer stem-like cells together with enhanced autophagy may cause resistance to radiation therapy/chemotherapy and that targeting the cancer stem-like cell in astrocytoma may offer a viable therapeutic approach.

scholarly journals Novel prognostic marker LINC00205 promotes tumorigenesis and metastasis by competitively suppressing miRNA-26a in gastric cancer

2022 ◽  
Vol 8 (1) ◽  
Author(s):  
Longtao Huangfu ◽  
Biao Fan ◽  
Gangjian Wang ◽  
Xuejun Gan ◽  
Shanshan Tian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Lines ◽  
Poor Prognosis ◽  
Epithelial Mesenchymal Transition ◽  
Serum Samples ◽  
Mesenchymal Transition ◽  
Non Coding Rna ◽  
Public Datasets ◽  
High Level

AbstractRapid proliferation and metastasis of gastric cancer (GC) resulted in a poor prognosis in the clinic. Previous studies elucidated that long non-coding RNA (LncRNA) LINC00205 was upregulated in various tumors and participated in tumor progression. The aim of our study was to investigate the regulating role of LINC00205 in tumorigenesis and metastasis of GC. Both public datasets and our data showed that the LINC00205 was highly expressed in GC tissues and several cell lines. Notably, GC patients with high level of LINC00205 had a poor prognosis in our cohort. Mechanistically, knockdown of LINC00205 by shRNAs suppressed GC cells proliferation, migration, invasion remarkably, and induced cell cycle arrest. Based on bioinformatics prediction, we found that LINC00205 might act as a competitive endogenous RNA (ceRNA) through targeting miR-26a. The level of miR-26a had negatively correlated with LINC00205 expression and was decreased among GC cell lines, tissues, and serum samples. Our results for the first time confirmed that miR-26a was a direct target of LINC00205 and might have the potential to become a plasma marker for clinical tumor diagnosis. Indeed, LINC00205 knockdown resulted in the dramatic promotion of miR-26a expression as well as inhibition of miR-26a potential downstream targets, such as HMGA2, EZH2, and USP15. These targets were essential for cell survival and epithelial-mesenchymal transition. Importantly, LINC00205 was able to remodel the miR-26a-mediated downstream silence, which identified a new mechanism of malignant transformation of GC cells. In conclusion, this study revealed the regulating role of the LINC00205/miR-26a axis in GC progression and provided a new potential therapeutic strategy for GC treatment.

scholarly journals High Level of COP1 Expression is Associated with Poor Prognosis in Primary Gastric Cancer

2012 ◽  
Vol 8 (8) ◽  
pp. 1168-1177 ◽  
Author(s):  
Yuan-fang Li ◽  
Dan-dan Wang ◽  
Bai-wei Zhao ◽  
Wei Wang ◽  
Chun-yu Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Primary Gastric Cancer ◽  
High Level

scholarly journals High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients

2014 ◽  
Vol 12 (1) ◽  
pp. 17 ◽  
Author(s):  
Hiroki Sato ◽  
Kanako C Hatanaka ◽  
Yutaka Hatanaka ◽  
Hiromitsu Hatakeyama ◽  
Ari Hashimoto ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Neck Squamous Cell Carcinoma ◽  
High Level Expression ◽  
High Level
Sign in / Sign up

Export Citation Format

Share Document