scholarly journals Correlation of Altered Expression of the Autophagy Marker LC3B with Poor Prognosis in Astrocytoma

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Daniel Winardi ◽  
Hung-Pei Tsai ◽  
Chee-Yin Chai ◽  
Chia-Li Chung ◽  
Joon-Khim Loh ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Poor Prognosis ◽  
Beclin 1 ◽  
High Level Expression ◽  
Altered Expression ◽  
Protein Expressions ◽  
Weak Expression ◽  
High Level ◽  
The Relationship ◽  
Resistance To Chemotherapy

Glioblastoma multiforme is one of the most serious malignant brain tumors and is characterized by resistance to chemotherapy and radiation therapy. Recent studies suggest that autophagy may play an important role not only in the regulation of cancer development and progression but also in determining the response of cancer cells to anticancer therapy. The purpose of the present study was to assess the relationship between protein expressions of two autophagy markers, LC3B and Beclin-1, with clinical parameters in astrocytoma patients. Furthermore, the expression of CD133, a marker of the cancer stem-like cells, in astrocytoma patients was also investigated. A total of 106 thin-section slides were retrospectively collected from astrocytoma patients. LC3B, but not Beclin-1, protein expression was found to significantly correlate with resistance to radiation- or chemotherapy. In addition, high intensity of LC3B staining was predictive of poor prognosis. Furthermore, survival time of patients with high-level expression in both CD133 and LC3B was significantly shorter than those with weak expression in both CD133 and LC3B. These results suggest that astrocytoma cancer stem-like cells together with enhanced autophagy may cause resistance to radiation therapy/chemotherapy and that targeting the cancer stem-like cell in astrocytoma may offer a viable therapeutic approach.

scholarly journals High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (29) ◽  
pp. 46042-46055 ◽  
Author(s):  
Chao Li ◽  
Jian Chen ◽  
Yupeng Wang ◽  
Guohe Song ◽  
Chao Xiao ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level Expression ◽  
High Level

scholarly journals Correction: High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (27) ◽  
pp. 45031-45031 ◽  
Author(s):  
Chao Li ◽  
Jian Chen ◽  
Yupeng Wang ◽  
Guohe Song ◽  
Chao Xiao ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level Expression ◽  
High Level

High‐level expression of PRSS3 correlates with metastasis and poor prognosis in patients with gastric cancer

2019 ◽  
Vol 119 (8) ◽  
pp. 1108-1121 ◽  
Author(s):  
Fei Wang ◽  
Yi‐Lin Hu ◽  
Ying Feng ◽  
Yi‐Bing Guo ◽  
Yi‐Fei Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
High Level Expression ◽  
High Level

Comparison of the effects of C-KIT, MMP-2, Ki-67, Bcl-2 and metallothionein expression on prognostic factors in skin and non-skin malignant melanomas

2021 ◽  
Author(s):  
Berna Eriten ◽  
Fahrettin Göze
Keyword(s):  
Prognostic Factors ◽  
Poor Prognosis ◽  
Cell Kinetics ◽  
Rare Event ◽  
Invasion And Metastasis ◽  
Ki 67 ◽  
Significant Difference ◽  
The Difference ◽  
High Level ◽  
The Relationship

Abstract Objectives: We aimed the relationship between with selected prognostic factors of MM, 1) C-KIT (CD117), which related to MM pathogenesis, 2) Ki-67, which is the determinant of cell kinetics, 3) MMP-2, which degradation of the basement membrane and extracellular matrix required for cell migration, invasion and metastasis in melanogenesis, 4) bcl-2, which reduces the apoptotic response to cytotoxic chemotherapy and 5) MT’s whose overexpression shows resistance to anticancer drugs and radiotherapy and thus poor prognosis.Material and Methods: In this study, 30 skin and 15 non-skin MMM cases diagnosed between January 01, 2000 and June 01, 2011 in SCU-TF Medical Pathology Department were examined. C-Kit, MMP-2, Ki-67, bcl-2 and MT markers were applied to these cases.Results: When comparing the skin and non-skin groups, the difference between Ki-67 and MMP-2 expressions was found to be statistically significant, but no significant difference was found in staining with c-Kit, MT and bcl-2. It was thought that high MMP-2, C-KIT, bcl-2 expressions and high Ki-67 index as well as loss of MT expression might be associated with poor prognosis. Despite the high level of KIT immunostaining in melanomas, this parameter does not appear to be a good predictor of the presence of molecular mutations. Mutations that activate KIT should be considered a rare event in this tumor.

High-Level Expression of S100A4 Correlates with Lymph Node Metastasis and Poor Prognosis in Patients with Gastric Cancer

2009 ◽  
Vol 17 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Yuan-Yu Wang ◽  
Zai-Yuan Ye ◽  
Zhong-Sheng Zhao ◽  
Hou-Quan Tao ◽  
Yong-Quan Chu
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Poor Prognosis ◽  
High Level Expression ◽  
Node Metastasis ◽  
High Level
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