High-level expression of periostin is closely related to metastatic potential and poor prognosis of hepatocellular carcinoma

2012 ◽  
Vol 30 (1) ◽  
Author(s):  
Yang Lv ◽  
Wei Wang ◽  
Wei-Dong Jia ◽  
Qi-Kai Sun ◽  
Jian-Sheng Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level Expression ◽  
High Level

scholarly journals High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (29) ◽  
pp. 46042-46055 ◽  
Author(s):  
Chao Li ◽  
Jian Chen ◽  
Yupeng Wang ◽  
Guohe Song ◽  
Chao Xiao ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level Expression ◽  
High Level

scholarly journals Correction: High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (27) ◽  
pp. 45031-45031 ◽  
Author(s):  
Chao Li ◽  
Jian Chen ◽  
Yupeng Wang ◽  
Guohe Song ◽  
Chao Xiao ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level Expression ◽  
High Level

scholarly journals Activation of β-Catenin by Hypoxia in Hepatocellular Carcinoma Contributes to Enhanced Metastatic Potential and Poor Prognosis

2010 ◽  
Vol 16 (10) ◽  
pp. 2740-2750 ◽  
Author(s):  
Liang Liu ◽  
Xiao-Dong Zhu ◽  
Wen-Quan Wang ◽  
Yuan Shen ◽  
Yi Qin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential

Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway

2021 ◽  
Author(s):  
Qian Ding ◽  
Caihua Jiang ◽  
Yajing Zhou ◽  
Jianping Duan ◽  
Jianming Lai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Family Member ◽  
Poor Prognosis ◽  
Migration And Invasion ◽  
Erk Pathway ◽  
High Level ◽  
The Impact ◽  
Kinesin Family ◽  
Hcc Cells

ABSTRACT The current work was intended to explore the function and mechanism of Kinesin family member 2C (KIF2C) in hepatocellular carcinoma (HCC). In this study, KIF2C expression was at a high level in HCC and indicated poor prognosis. Silencing KIF2C significantly suppressed the proliferation, migration and invasion in HCC cells. Furthermore, silencing KIF2C markedly decreased the expression of Snail, Vimentin, p-MEK and p-ERK, but increased E-cadherin expression in HCC cells. Moreover, we also found that MEK/ERK inhibitor U0126 could enhance the impact on cell proliferation, migration and invasion induced by silencing KIF2C in HCC. On the contrary, MEK/ERK activator PAF could weaken the impact induced by silencing KIF2C in HCC. Thus, our findings indicate that KIF2C can promote the proliferation, migration and invasion by activating MEK/ERK pathway in HCC.

scholarly journals Correlation of Altered Expression of the Autophagy Marker LC3B with Poor Prognosis in Astrocytoma

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Daniel Winardi ◽  
Hung-Pei Tsai ◽  
Chee-Yin Chai ◽  
Chia-Li Chung ◽  
Joon-Khim Loh ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Poor Prognosis ◽  
Beclin 1 ◽  
High Level Expression ◽  
Altered Expression ◽  
Protein Expressions ◽  
Weak Expression ◽  
High Level ◽  
The Relationship ◽  
Resistance To Chemotherapy

Glioblastoma multiforme is one of the most serious malignant brain tumors and is characterized by resistance to chemotherapy and radiation therapy. Recent studies suggest that autophagy may play an important role not only in the regulation of cancer development and progression but also in determining the response of cancer cells to anticancer therapy. The purpose of the present study was to assess the relationship between protein expressions of two autophagy markers, LC3B and Beclin-1, with clinical parameters in astrocytoma patients. Furthermore, the expression of CD133, a marker of the cancer stem-like cells, in astrocytoma patients was also investigated. A total of 106 thin-section slides were retrospectively collected from astrocytoma patients. LC3B, but not Beclin-1, protein expression was found to significantly correlate with resistance to radiation- or chemotherapy. In addition, high intensity of LC3B staining was predictive of poor prognosis. Furthermore, survival time of patients with high-level expression in both CD133 and LC3B was significantly shorter than those with weak expression in both CD133 and LC3B. These results suggest that astrocytoma cancer stem-like cells together with enhanced autophagy may cause resistance to radiation therapy/chemotherapy and that targeting the cancer stem-like cell in astrocytoma may offer a viable therapeutic approach.

High‐level expression of PRSS3 correlates with metastasis and poor prognosis in patients with gastric cancer

2019 ◽  
Vol 119 (8) ◽  
pp. 1108-1121 ◽  
Author(s):  
Fei Wang ◽  
Yi‐Lin Hu ◽  
Ying Feng ◽  
Yi‐Bing Guo ◽  
Yi‐Fei Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
High Level Expression ◽  
High Level
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