Is elevated microsatellite alterations at selected tetranucleotide repeats (EMAST)‐negative/MSI‐high colorectal cancer a distinct subtype of the disease?

2020 ◽  
Vol 122 (7) ◽  
pp. 1462-1469
Author(s):  
Yeshong Park ◽  
Duck‐Woo Kim ◽  
Yun Ji Hong ◽  
Kyoung Un Park ◽  
Soo Kyung Nam ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tetranucleotide Repeats ◽  
Distinct Subtype

scholarly journals Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients

2020 ◽  
Vol 21 (10) ◽  
pp. 3532 ◽  
Author(s):  
Francesca Pirini ◽  
Luigi Pasini ◽  
Gianluca Tedaldi ◽  
Emanuela Scarpi ◽  
Giorgia Marisi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Progression Free Survival ◽  
Vascular Endothelial ◽  
Free Survival ◽  
Antiangiogenic Treatment ◽  
Tetranucleotide Repeats ◽  
Few Data ◽  
Colorectal Cancer Patients ◽  
Endothelial Growth Factor

Very few data are reported in the literature on the association between elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and prognosis in advanced colorectal cancer. Moreover, there is no information available in relation to the response to antiangiogenic treatment. We analyzed EMAST and vascular endothelial growth factor-B (VEGF-B) microsatellite status, together with standard microsatellite instability (MSI), in relation to prognosis in 141 patients with metastatic colorectal cancer (mCRC) treated with chemotherapy (CT) alone (n = 51) or chemotherapy with bevacizumab (B) (CT + B; n = 90). High MSI (MSI-H) was detected in 3% of patients and was associated with progression-free survival (PFS; p = 0.005) and overall survival (OS; p < 0.0001). A total of 8% of cases showed EMAST instability, which was associated with worse PFS (p = 0.0006) and OS (p < 0.0001) in patients treated with CT + B. A total of 24.2% of patients showed VEGF-B instability associated with poorer outcome in (p = 0.005) in the CT arm. In conclusion, our analysis indicated that EMAST instability is associated with worse prognosis, particularly evident in patients receiving CT + B.

The clinical features and genomic landscape of elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) in patients with colorectal cancer.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e15591-e15591
Author(s):  
Ming Huang Chen ◽  
Shih-Ching Chang ◽  
Jen-Kou Lin ◽  
Shung-Haur Yang ◽  
Jeng-Kai Jiang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Features ◽  
Genomic Landscape ◽  
Tetranucleotide Repeats

Mucinous adenocarcinoma is a pharmacogenomically distinct subtype of colorectal cancer

2019 ◽  
Vol 20 (3) ◽  
pp. 524-532 ◽  
Author(s):  
Ian S. Reynolds ◽  
Emer O’Connell ◽  
Michael Fichtner ◽  
Deborah A. McNamara ◽  
Elaine W. Kay ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mucinous Adenocarcinoma ◽  
Distinct Subtype

scholarly journals Combined Microsatellite Instability and Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) Might Be a More Promising Immune Biomarker in Colorectal Cancer

2019 ◽  
Vol 24 (12) ◽  
pp. 1534-1542 ◽  
Author(s):  
Ming‐Huang Chen ◽  
Shih‐Ching Chang ◽  
Pei‐Ching Lin ◽  
Shung‐Haur Yang ◽  
Chun‐Chi Lin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Tetranucleotide Repeats

Deletion mapping on chromosome 6 in colorectal cancer associated with ulcerative colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A121-A122
Author(s):  
T EZAKI ◽  
M WATANABE ◽  
S FUNAKOSHI ◽  
M NAGANUMA ◽  
T AZUMA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ulcerative Colitis ◽  
Deletion Mapping ◽  
Chromosome 6
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