The changing landscape in management of desmoplastic melanoma

2021 ◽  
Author(s):  
Jonathan A. Dunne ◽  
George Adigbli
Keyword(s):  
Desmoplastic Melanoma

scholarly journals Evolution of superficial spreading melanoma to resemble desmoplastic melanoma: case report

2021 ◽  
Author(s):  
Martin G. Cook ◽  
Barry W. E. M. Powell ◽  
Megan E. Grant ◽  
Adele C. Green
Keyword(s):  
Case Report ◽  
Clinical Management ◽  
Unusual Case ◽  
Primary Site ◽  
Mixed Tumor ◽  
Superficial Spreading ◽  
Superficial Spreading Melanoma ◽  
Desmoplastic Melanoma ◽  
Mixed Features ◽  
Melanoma Case

AbstractDesmoplastic melanoma commonly occurs on the head and neck in a pure form, but occasionally, it occurs in a mixed tumor with another type, usually superficial spreading melanoma (SSM), and rarely as a metastasis from a primary SSM. We report here a primary SSM on the leg of a 32-year-old male which metastasised to lymph nodes, and 10 years later recurred at the primary site initially with mixed features but evolving to resemble a uniformly desmoplastic, deeply invasive melanoma. This unusual case has implications for clinical management and is additionally notable for its reversal in behavior, from metastatic to local infiltrative type, correlating with the change in morphology.

Desmoplastic melanoma in a fingertip: A rare entity

2015 ◽  
Vol 68 (2) ◽  
pp. e45-e46
Author(s):  
Jurga Pikturnaite ◽  
Jill Webb
Keyword(s):  
Rare Entity ◽  
Desmoplastic Melanoma

Acute appendicitis secondary to desmoplastic melanoma metastasis in immune-checkpoint inhibitors era

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Gianluca Avallone ◽  
Chiara Astrua ◽  
Paolo Fava ◽  
Luca Tonella ◽  
Luca Mastorino ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Melanoma Metastasis ◽  
Desmoplastic Melanoma

An Unusual Case of Desmoplastic Melanoma With Monster Cells Imitating an Atypical Fibroxanthoma

2021 ◽  
pp. 106689692110447
Author(s):  
Juan J. Ríos-Martín ◽  
Manuel Pérez-Pérez ◽  
Sebastián Umbría-Jiménez ◽  
David Moreno-Ramírez ◽  
Ana Vallejo-Benítez
Keyword(s):  
Cyclin D1 ◽  
Copy Number ◽  
Poor Prognosis ◽  
Unusual Case ◽  
Prognostic Significance ◽  
Mutation Status ◽  
Atypical Fibroxanthoma ◽  
Desmoplastic Melanoma ◽  
Aggressive Tumor

Numerous cells with very large and irregular nuclei (“monster” cells) have not hitherto been reported in desmoplastic melanoma (DM). Their prognostic significance in melanomas is a matter of debate, although some authors have associated them with more aggressive tumor behavior. We report a mixed DM on the scalp of an 88-year-old woman imitating an atypical fibroxanthoma. Tumor cells stained positive for SOX10, S100, and cyclin D1; BRAF mutation status was negative, and fluorescence in situ hybridization analysis showed copy number gains in 11q13 (cyclin D1) and 6p25 (RREB1), and loss in 6q23 (MYB). Cyclin D1 amplification is associated with poor prognosis in melanoma.

Tyrosinase Expression in Malignant Melanoma, Desmoplastic Melanoma, and Peripheral Nerve Tumors

2002 ◽  
Vol 126 (7) ◽  
pp. 816-822 ◽  
Author(s):  
Jenny L. Boyle ◽  
Helen M. Haupt ◽  
Jere B. Stern ◽  
Hinke A. B. Multhaupt
Keyword(s):  
Peripheral Nerve ◽  
S100 Protein ◽  
Dermatofibrosarcoma Protuberans ◽  
Antigen Retrieval ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Desmoplastic Melanoma ◽  
Nerve Sheath ◽  
Tyrosinase Expression ◽  
Hmb 45

Abstract Context.—Pathologists may encounter problems in the differential diagnosis of malignant melanoma, spindle and epithelioid neoplasms of peripheral nerves, and fibrohistiocytic tumors. Tyrosinase has been demonstrated to be a sensitive marker for melanoma. Objective.—To determine the specificity of tyrosinase expression in the differential diagnosis of melanoma, desmoplastic melanoma, and peripheral nerve sheath tumors. Design.—Immunoreactivity for tyrosinase, HMB-45 (anti-gp100 protein), S100 protein, CD34, and vimentin was studied in 70 tumors, including 15 melanomas (5 desmoplastic, 4 amelanotic, 6 melanotic), 13 malignant peripheral nerve sheath tumors; 10 schwannomas (1 pigmented), 12 neurofibromas (4 pigmented), and 20 fibrohistiocytic tumors (10 dermatofibrosarcoma protuberans and 10 dermatofibromas). Microwave-based antigen retrieval was performed in 10mM citrate buffer, pH 6.0, for 20 minutes at 121°C. Results.—All melanomas demonstrated positive immunostaining for tyrosinase, HMB-45, and S100 protein. Immunoreactivity for HMB-45 was generally stronger than that for tyrosinase in amelanotic lesions and significantly stronger in 1 of the desmoplastic lesions. The 4 pigmented neurofibromas were focally positive for tyrosinase, but did not stain for HMB-45. The pigmented schwannoma was focally positive for both tyrosinase and HMB-45. The malignant peripheral nerve sheath tumors, dermatofibrosarcoma protuberans, and dermatofibromas were nonreactive for tyrosinase and HMB-45. Conclusions.—Our results support the sensitivity of tyrosinase expression and demonstrate the relative specificity of tyrosinase as a marker for melanocytic lesions, including desmoplastic melanoma, although pigmented peripheral nerve tumors may demonstrate focal positive staining. Immunoreactivity for tyrosinase and HMB-45 may have been enhanced by the microwave-based antigen-retrieval technique used in this study.

Desmoplastic melanoma: Recent advances and persisting challenges

Pathology ◽  
2013 ◽  
Vol 45 (5) ◽  
pp. 453-463 ◽  
Author(s):  
Benjamin A. Wood
Keyword(s):  
Desmoplastic Melanoma ◽  
Recent Advances

scholarly journals Primary Cutaneous Melanoma Arising in a Long-Standing Irradiated Keloid

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Lindsay M. Fish ◽  
Lisa Duncan ◽  
Keith D. Gray ◽  
John L. Bell ◽  
James M. Lewis
Keyword(s):  
Ionizing Radiation ◽  
Cutaneous Melanoma ◽  
Low Dose ◽  
Primary Cutaneous Melanoma ◽  
Desmoplastic Melanoma ◽  
Increased Risk ◽  
Clinical Conditions

Ionizing radiation has been used therapeutically for a variety of clinical conditions, including treatment of hypertrophic keloids. Keloids may rarely be associated with malignancy, but the use of low-dose ionizing radiation is associated with an increased risk of cutaneous malignancies. We describe a case in which a primary desmoplastic melanoma arose in a long-standing, previously irradiated keloid.

27. Pathological features of metastases from primary cutaneous desmoplastic melanoma

Pathology ◽  
2011 ◽  
Vol 43 ◽  
pp. S97
Author(s):  
Rajmohan Murali ◽  
Diana Zannino ◽  
Maria Synnott ◽  
Stanley McCarthy ◽  
John Thompson ◽  
...  
Keyword(s):  
Pathological Features ◽  
Desmoplastic Melanoma

Perineural extension of cutaneous desmoplastic melanoma mimicking an intracranial malignant peripheral nerve sheath tumor

2011 ◽  
Vol 115 (2) ◽  
pp. 273-277 ◽  
Author(s):  
Samuel L. Barnett ◽  
Michael J. Wells ◽  
Bruce Mickey ◽  
Kimmo J. Hatanpaa
Keyword(s):  
Peripheral Nerve ◽  
Skin Lesions ◽  
Nerve Sheath Tumor ◽  
Facial Skin ◽  
Perineural Spread ◽  
Peripheral Nerve Sheath Tumor ◽  
Desmoplastic Melanoma ◽  
Nerve Sheath ◽  
Diagnostic Difficulties ◽  
The Brain

The authors present a case illustrating the importance of obtaining a biopsy of any facial skin lesions in a patient presenting with an intracranial tumor involving the facial or trigeminal nerve. Conventional malignant melanoma metastasizes to the brain frequently and does not usually pose diagnostic difficulties. Direct intracranial spread of cutaneous melanoma is rare. In our patient, desmoplastic melanoma with perineural spread to the Meckel cave mimicked a malignant peripheral nerve sheath tumor clinically, radiographically, and histologically.

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