Preoperative prognostic nutritional index and systemic immune‐inflammation index predict survival outcomes in osteosarcoma: A comparison between young and elderly patients

2021 ◽  
Author(s):  
Cong Ma ◽  
Ronghui Yu ◽  
Junhong Li ◽  
Jingjing Guo ◽  
Jianyun Xu ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Prognostic Nutritional Index ◽  
Survival Outcomes ◽  
Nutritional Index ◽  
Immune Inflammation

scholarly journals Prognostic nutritional index in elderly patients hospitalized for acute heart failure

2020 ◽  
Vol 7 (5) ◽  
pp. 2479-2484 ◽  
Author(s):  
Matteo Candeloro ◽  
Marcello Di Nisio ◽  
Martina Balducci ◽  
Stefano Genova ◽  
Emanuele Valeriani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Elderly Patients ◽  
Acute Heart Failure ◽  
Prognostic Nutritional Index ◽  
Nutritional Index

scholarly journals Clinical and therapeutic features and prognostic factors of metastatic colorectal cancer over age 80: a retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hiroyuki Hisada ◽  
Yu Takahashi ◽  
Manabu Kubota ◽  
Haruhisa Shimura ◽  
Ei Itobayashi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Elderly Patients ◽  
Metastatic Colorectal Cancer ◽  
Carcinoembryonic Antigen ◽  
Prognostic Nutritional Index ◽  
Hazard Ratio ◽  
Elderly Group ◽  
Younger Patients ◽  
Nutritional Index

Abstract Background Colorectal cancer (CRC) is one of the most common cancers in the world. The number of elderly patients with CRC increases due to aging of the population. There are few studies that examined chemotherapy and prognostic factors in metastatic colorectal cancer (mCRC) patients aged ≥ 80 years. We assessed the efficacy of chemotherapy and prognostic factors among patients with mCRC aged ≥ 80 years. Methods We retrospectively analyzed clinical and laboratory findings of 987 patients newly diagnosed with CRC at Asahi General Hospital (Chiba, Japan) between January 2012 and December 2016. The Kaplan–Meier method was used for the overall survival (OS) and the log-rank test was used to identify difference between patients. A multivariate Cox proportional hazard regression analysis was performed to determine the hazard ratios and 95% confidence intervals (CIs) of prognostic factors among super-elderly patients. Results In total, 260 patients were diagnosed with mCRC (super-elderly group: n = 43, aged ≥ 80 years and younger group, n = 217, aged < 80 years). The performance status and nutritional status were worse in the super-elderly group than in the younger group. The OS of super-elderly patients who received chemotherapy was worse than that of younger patients (18.5 vs. 28.8 months; P = 0.052), although the difference was not significant. The OS of patients who received chemotherapy tended to be longer than that of those who did not; however, there were no significant differences in OS in the super-elderly group (18.5 vs. 8.4 months P = 0.33). Multivariate analysis revealed that carcinoembryonic antigen levels ≥ 5 ng/mL (hazard ratio: 2.27; 95% CI 1.09–4.74; P = 0.03) and prognostic nutritional index ≤ 35 (hazard ratio: 8.57; 95% CI 2.63–27.9; P = 0.0003) were independently associated with poor OS in the super-elderly group. Conclusions Patients with mCRC aged ≥ 80 years had lower OS than younger patients even though they received chemotherapy. Carcinoembryonic antigen and prognostic nutritional index were independent prognostic factors in super-elderly patients with mCRC, but chemotherapy was not. Trial registration: retrospectively registered.

scholarly journals Impact of the preoperative prognostic nutritional index on survival outcomes in upper tract urothelial carcinomas

2019 ◽  
Vol 8 (6) ◽  
pp. 2971-2978 ◽  
Author(s):  
Wenbin Xue ◽  
Ping Tan ◽  
Hang Xu ◽  
Lu Yang ◽  
Qiang Wei
Keyword(s):  
Prognostic Nutritional Index ◽  
Survival Outcomes ◽  
Upper Tract ◽  
Nutritional Index ◽  
Urothelial Carcinomas

scholarly journals Prognostic Nutritional Index and Systemic Immune-Inflammation Index Predict the Prognosis of Patients with HCC

2020 ◽  
Author(s):  
Dong Wang ◽  
Xi Hu ◽  
Liang Xiao ◽  
Guo Long ◽  
Lei Yao ◽  
...  
Keyword(s):  
Prognostic Nutritional Index ◽  
Nutritional Index ◽  
Immune Inflammation

Prognostic nutritional index (PNI): A predictive factor for elderly patients with COPD

2020 ◽  
Author(s):  
Eiko Suzuki ◽  
Naoko Kawata ◽  
Jun Ikari ◽  
Rie Anazawa ◽  
Masaki Suzuki ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Predictive Factor ◽  
Prognostic Nutritional Index ◽  
Nutritional Index

scholarly journals Comparison of Systemic Immune-Inflammation Index (SII), Early Warning Score (ANDC) and Prognostic Nutritional Index (PNI) in Hospitalized Patients with Malignancy, and Their Influence on Mortality from COVID-19

2021 ◽  
Author(s):  
Muge Bilge ◽  
Isil Kibar Akilli ◽  
Aylia Yesilova ◽  
Kadriye Kart Yasar
Keyword(s):  
Early Warning ◽  
Prognostic Significance ◽  
Prognostic Nutritional Index ◽  
Biological Indicators ◽  
Early Warning Score ◽  
Hospital Death ◽  
Lymphocyte Ratio ◽  
Nutritional Index ◽  
Mortality Ratio ◽  
Immune Inflammation

Abstract Introduction: COVID-19 pandemic is a serious cause of increased mortality in patients having malignancy. Therefore, to help predict the clinical progression of those patients with COVID-19 who have multiple comorbidities as cancer, we need various indices whose parameters we can easily measure and rapidly calculate. We evaluated several biological indicators based on inflammation and/or nutritional status, such as systemic immune-inflammation index (SII), early warning score (ANDC) and prognostic nutritional index (PNI) in hospitalized COVID-19 patients with and without malignancies for a prognostic significance. Methodology: This is a retrospective and observational study on 186 patients with SARS-CoV-2, who were diagnosed with COVID-19 by real-time PCR testing and hospitalized due to COVID-19 pneumonia. 75 patients had various malignancies, and the rest (111), having a similar age and comorbidity profile based on propensity score matching, had no malignancy. Results: None of the measures as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (MLR), monocyte to lymphocyte ratio (PLR), SII, PNI or ANDC was found to be significantly different between two groups. Mortality ratio was found to be significantly higher in malignancy group (17,3%). Odds ratio for the mortality, OR:2,39 (%95 CI:1,80 -3,16) was found to be significantly higher for the malignancy group, even though the duration of hospitalization was statistically similar for both groups. PNI was found to be significantly lower for deceased patients compared with survivors in the malignancy group. Contrarily, ANDC was found to be significantly higher for deceased patients in the malignancy group. Conclusions: PNI and ANDC have independent predictive power on determining the in-hospital death in COVID-19 malignancy cases. It is suggested that ANDC seems to be a more sensitive score than SII in COVID-19 cases with malignancies.

Systemic immune-inflammation index predicting survival outcome in patients with classical Hodgkin lymphoma

2019 ◽  
Vol 13 (18) ◽  
pp. 1565-1575 ◽  
Author(s):  
Cem Mirili ◽  
Semra Paydas ◽  
Tuba Korkmaz Kapukaya ◽  
Ali Yılmaz
Keyword(s):  
Overall Survival ◽  
Hodgkin Lymphoma ◽  
Prognostic Nutritional Index ◽  
Progression Free Survival ◽  
Free Survival ◽  
Cox Regression Analysis ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Nutritional Index ◽  
Immune Inflammation

Aim: To evaluate the prognostic significance of neutrophil lymphocyte ratio, prognostic nutritional index, systemic immune-inflammation index (SII) and B2M in Hodgkin Lymphoma (HL). Materials & methods: Neutrophil–lymphocyte ratio, prognostic nutritional index, SII and B2M were analyzed to assess their prognostic value via the Kaplan–Meier method and Cox regression analysis in 122 HL patients, retrospectively. Results: SII was found to have the highest area under curve and the most sensitive and specific among all markers. In univariate analyses, all four parameters were prognostic for overall survival and progression-free survival, in multivariate analyzes only SII was found to be independent factors for both of them. Conclusion: SII can be suggested as a novel independent and better prognostic factor for predicting overall survival and progression-free survival in HL.

The use of preoperative prognostic nutritional index and age to predict postoperative delirium in elderly patients

2020 ◽  
Vol 20 (5) ◽  
pp. 805-806
Author(s):  
Shao‐Hua Liu ◽  
Fu‐Shan Xue ◽  
Hai‐Jun Hou
Keyword(s):  
Elderly Patients ◽  
Postoperative Delirium ◽  
Prognostic Nutritional Index ◽  
Nutritional Index

scholarly journals Predictive value of prognostic nutritional index and systemic immune‐inflammation index on tumor progression in bladder cancer patients with after radical cystectomy

2020 ◽  
Author(s):  
Jiatong Zhou ◽  
Xitong Xu ◽  
RanLu Liu
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Predictive Value ◽  
Cox Regression ◽  
Prognostic Nutritional Index ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Nutritional Index ◽  
Immune Inflammation ◽  
Muscle Invasive

Abstract OBJECTIVES: The purpose of this study was to explore the predictive value of preoperative prognostic nutritional index(PNI) and systemic immune‐inflammation index(SII) for local tumor stage in bladder cancer(BC) after radical cystectomy(RC).METHODS: We researched our database between April 2011 and October 2019. There were 195 BC patients who underwent RC. The PNI and SII were calculated using preoperative blood sample results. The predictive value of SII and PNI was analysed with univariate and multivariate Cox regression models. Receiver operating characteristic (ROC) was used to determine the optimum PNI. Signifcant P was P<0.05.RESULTS: Of patients, all patients were males with a mean age of 67.94±8.97years. Mean serum albumin was 42.13±4.28(g/L), mean PNI score was 51.29±6.09 and mean SII was 661.67±506.22. Multivariable Cox regression analysis demonstrated that PNI scores and SII could not play a significantly predictive factor between muscle invasive bladder cancer(MIBC) and non-muscle-invasive bladder cancer(NMIBC). While we also found PNI was an independent risk factors for predicting tumor stagep(pT＜3a and pT≥3a).CONCLUSIONS: Our research revealed that preoperative low PNI but not SII could be used as an independent factor to predict worse pathologically stage(pT≥3a). But preoperative PNI and SII might not were significantly related with the incidence risk of muscle invasive. We still need future studies with large cohorts to identify our results.

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