Invasive fungal sinusitis in post COVID ‐19 patients: a new clinical entity

AbstractBackground:Scytalidium dimidiatum is a soil and plant pathogen that frequently affects fruit trees, but can also cause human infection. There are only two reported cases of invasive fungal sinusitis involving this rare micro-organism.Objective:This paper reports the first case of invasive fungal sinusitis caused by Scytalidium dimidiatum occurring in a young immunocompetent patient from a non-endemic region, and discusses potential sources of exposure and relevance of local factors.Method:Case report.Results:The patient was treated successfully with a combination of functional endoscopic sinus surgery, and antifungal and corticosteroid treatment.Conclusion:This paper describes the first reported case of invasive fungal sinusitis secondary to Scytalidium dimidiatum in a young immunocompetent patient from a non-endemic region. Importance is placed on following a systematic process of investigation and management, and adhering to well-defined basic surgical principles.

Download Full-text

Acute invasive fungal sinusitis in immunocompromised children

Hematology Transfusion and Cell Therapy ◽

10.1016/j.htct.2021.01.012 ◽

2021 ◽

Author(s):

Rejin Kebudi

Keyword(s):

Fungal Sinusitis ◽

Invasive Fungal Sinusitis

Download Full-text

Prognostic Factors in the Outcome of Invasive Fungal Sinusitis in a Pediatric Population

The Pediatric Infectious Disease Journal ◽

10.1097/inf.0000000000001015 ◽

2016 ◽

Vol 35 (4) ◽

pp. 384-386 ◽

Cited By ~ 11

Author(s):

Katherine K. Green ◽

Henry P. Barham ◽

Gregory C. Allen ◽

Kenny H. Chan

Keyword(s):

Prognostic Factors ◽

Pediatric Population ◽

Fungal Sinusitis ◽

Invasive Fungal Sinusitis

Download Full-text

Chronic Invasive Fungal Sinusitis With Negative Histopathology: A Diagnostic Challenge

Ear Nose & Throat Journal ◽

10.1177/0145561320973773 ◽

2021 ◽

pp. 014556132097377

Author(s):

Anne Ning ◽

Arminé Kocharyan ◽

W Colby Brown ◽

Brian D’Anza

Keyword(s):

Definitive Diagnosis ◽

Fungal Sinusitis ◽

Chain Reaction ◽

Diagnostic Challenge ◽

Invasive Fungal Sinusitis ◽

Fungal Organisms ◽

Fungal Dna ◽

Polymerase Chain ◽

Histopathologic Findings ◽

Chronic Invasive

Although the diagnosis of chronic invasive fungal sinusitis relies chiefly on identification of invasive fungi on histology, the insidious nature of the disease can preclude detection of fungal organisms. Here, we present a case of chronic invasive fungal sinusitis with negative histopathologic findings and a definitive diagnosis made through fungal DNA detection. Clinicians should consider polymerase chain reaction an important complement to histology and culture in the diagnosis of chronic invasive fungal sinusitis.

Download Full-text

Invasive Fungal Sinusitis in Patients With Coronavirus Disease 2019 Seen in South India

Journal of Neuro-Ophthalmology ◽

10.1097/wno.0000000000001516 ◽

2022 ◽

Vol Publish Ahead of Print ◽

Author(s):

V. K. Hema ◽

Karthik Kumar ◽

Virna M. Shah

Keyword(s):

South India ◽

Fungal Sinusitis ◽

Invasive Fungal Sinusitis

Download Full-text

Invasive Fungal Sinusitis following Liver or Bone Marrow Transplantation

American Journal of Rhinology ◽

10.2500/105065894781874485 ◽

1994 ◽

Vol 8 (2) ◽

pp. 77-84 ◽

Cited By ~ 10

Author(s):

Perry J. Johnson ◽

William M. Lydiatt ◽

James V. Huerter ◽

Frederic P. Ogren ◽

Julie M. Vose ◽

...

Keyword(s):

Bone Marrow ◽

Bone Marrow Transplantation ◽

Marrow Transplantation ◽

Effective Means ◽

Management Strategies ◽

Retrospective Chart Review ◽

Signs And Symptoms ◽

Fungal Sinusitis ◽

Hematopoietic Growth Factors ◽

Invasive Fungal Sinusitis

Invasive fungal infection of the nose and paranasal sinuses occurs almost exclusively in immunocompromised patients and is increasingly recognized as a complication of organ transplantation. We performed a retrospective chart review of 955 bone marrow and 749 liver transplant patients to identify risk factors, presenting signs and symptoms, methods of diagnosis, and successful management strategies. We report on five cases following bone marrow transplantation and one case following liver transplantation. Neutropenia is the single most important risk factor in the development of and recovery from invasive fungal sinusitis. Early diagnosis, combined with antifungal agents, hematopoietic growth factors, and aggressive surgical debridement is the most effective means of management.

Download Full-text