Scytalidium dimidiatum associated invasive fungal sinusitis in an immunocompetent patient

2014 ◽  
Vol 128 (11) ◽  
pp. 1018-1021 ◽  
Author(s):  
A Hariri ◽  
N Choudhury ◽  
H A Saleh
Keyword(s):  
Corticosteroid Treatment ◽  
Fruit Trees ◽  
Immunocompetent Patient ◽  
Human Infection ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Fungal Sinusitis ◽  
Endemic Region ◽  
Invasive Fungal Sinusitis ◽  
First Case

AbstractBackground:Scytalidium dimidiatum is a soil and plant pathogen that frequently affects fruit trees, but can also cause human infection. There are only two reported cases of invasive fungal sinusitis involving this rare micro-organism.Objective:This paper reports the first case of invasive fungal sinusitis caused by Scytalidium dimidiatum occurring in a young immunocompetent patient from a non-endemic region, and discusses potential sources of exposure and relevance of local factors.Method:Case report.Results:The patient was treated successfully with a combination of functional endoscopic sinus surgery, and antifungal and corticosteroid treatment.Conclusion:This paper describes the first reported case of invasive fungal sinusitis secondary to Scytalidium dimidiatum in a young immunocompetent patient from a non-endemic region. Importance is placed on following a systematic process of investigation and management, and adhering to well-defined basic surgical principles.

scholarly journals Chronic Invasive Fungal Sinusitis: A Report of Two Atypical Cases

2002 ◽  
Vol 81 (7) ◽  
pp. 462-466 ◽  
Author(s):  
Nicolas Y. Busaba ◽  
Daryl G. Colden ◽  
William C. Faquin ◽  
Salah D. Salman
Keyword(s):  
Soft Tissues ◽  
Middle Turbinate ◽  
Sinus Surgery ◽  
Intracranial Extension ◽  
Dependent Diabetes Mellitus ◽  
Variant Form ◽  
Fungal Sinusitis ◽  
Pathologic Examination ◽  
Invasive Fungal Sinusitis ◽  
Fungal Hyphae

The purpose of this article is to describe a chronic variant of invasive fungal sinusitis (IFS) and discuss its management. This is a retrospective review of two cases of IFS that were characterized by atypical clinical courses. Patient 1 was a 75-year-old man with noninsulin-dependent diabetes mellitus who came to us with a 5-month history of headache. Computed tomography detected an opacified left sphenoid sinus. After the man failed to respond to medical therapy, he underwent a left endoscopic sphenoidotomy. Pathologic examination revealed that septate, branching fungal hyphae had invaded the soft tissues. The patient was started on oral itraconazole, but later switched to intravenous amphotericin B in response to intracranial extension. The man's disease stabilized, but he died a little more than 1 year later of unrelated causes. Patient 2 was an otherwise healthy 41-year-old woman who came to us with nasal congestion and unilateral nasal polyps. She underwent endoscopic sinus surgery. Pathologic examination identified granulomatous sinusitis and septate, branching fungal hyphae that had invaded the soft tissue of the middle turbinate. The patient was not treated with systemic antifungal medications because of the localized nature of the fungal invasion and the lack of bone invasion or erosion. She has now been symptom-free for 5 years. These two cases demonstrate that IFS can appear in a chronic variant form that is characterized by an indolent course and histologic evidence of tissue invasion by fungal hyphae. The type of treatment is dependent on the extent of the disease on initial examination and the rapidity of its progression.

Paranasal Sinuses Fungal Balls in Children

2010 ◽  
Vol 3 (3) ◽  
pp. 181-183
Author(s):  
Sunita Agarwal
Keyword(s):  
Case Report ◽  
Young Children ◽  
Ct Scan ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Fungal Sinusitis ◽  
Provisional Diagnosis ◽  
Invasive Fungal Sinusitis ◽  
First Case ◽  
Rule Out

Abstract Objective Rare cases of fungal balls of paranasal sinuses in children. No case has been reported in young children so far. However, allergic aspergillosis has been reported in young children. Method A case report of 2 cases of fungal balls of paranasal sinuses in children and review of the current literature concerning fungal balls of paranasal sinuses in children are presented. Result 2 cases of fungal balls in paranasal sinuses were diagnosed in children of 9 and 10 years respectively. Both of them presented with nasal obstruction and eye signs provisional diagnosis was based on CT scan findings. FESS was done and fungal balls were subjected to histopathological examination to rule out invasive fungal sinusitis, fungal staining and culture were done which confirmed the diagnosis of Aspergillosis. Conclusion To our knowledge this is the first case report of fungal balls in PNS in children in otolaryngology literature. Both the patients were males with age of 9 and 10 years respectively.

Functional Endoscopic Sinus Surgery in the Immunocompromised Child

1991 ◽  
Vol 105 (6) ◽  
pp. 818-825 ◽  
Author(s):  
Brian J. Wiatrak ◽  
Paul Willging ◽  
Charles M. Myer
Keyword(s):  
Endoscopic Sinus Surgery ◽  
Fatal Outcome ◽  
Chemotherapeutic Agents ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Fungal Sinusitis ◽  
Sinus Disease ◽  
Immunocompromised Child ◽  
Surgical Modality ◽  
Sinonasal Disease

Fungal sinusitis in the immunocompromised child is an aggressive, invasive process that may result in a fatal outcome if not diagnosed early. As a result of increasing use of bone marrow transplantation and new cytotoxic chemotherapeutic agents resulting in severe agranulocytopenia, more patients have become susceptible to fungal sinus disease. Functional endoscopic sinus surgery has emerged recently as an important surgical modality in the treatment of sinus disease in adults and children. Use of this technique in immunosuppressed children has allowed early diagnosis of fungal sinonasal disease, resulting in earlier surgical intervention. The high-quality fiberoptic capability of nasal endoscopes allows very detailed visualization of the internal anatomy of the nose and detects early mucosal changes as a result of intranasal fungal disease. Our experience using functional endoscopic sinus surgery in immunocompromised children over an 18-month period is reviewed. Our philosophy for diagnosis and management of immunocompromised children with suspected fungal sinonasal disease is discussed.

Report of the First Case of Invasive Fungal Sinusitis Caused by Scopulariopsis acremonium

1998 ◽  
Vol 124 (9) ◽  
pp. 1014 ◽  
Author(s):  
Matthew D. Ellison ◽  
Richard T. Hung ◽  
Kevin Harris ◽  
Bruce H. Campbell
Keyword(s):  
Fungal Sinusitis ◽  
Invasive Fungal Sinusitis ◽  
First Case

Bilateral Antrochoanal Polyp with Diabetes: A Rare Presentation of Cystic Fibrosis

2010 ◽  
Vol 3 (3) ◽  
pp. 173-176
Author(s):  
Monica Gupta ◽  
Manish Gupta
Keyword(s):  
Cystic Fibrosis ◽  
Endoscopic Sinus Surgery ◽  
English Literature ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Adolescent Male ◽  
Antrochoanal Polyp ◽  
Rare Presentation ◽  
First Case

Abstract Bilateral antrochoanal (AC) polyps have been rarely reported in english literature. Here we report the first case of an adolescent male with bilateral AC polyps, cystic fibrosis and diabetes. The case was managed successfully by functional endoscopic sinus surgery (FESS). The patient has been under follow-up for the last six months with no signs of recurrence.

A Case of Relapse of Invasive Fungal Sinusitis after Endoscopic Sinus Surgery

2013 ◽  
Vol 106 (2) ◽  
pp. 115-121
Author(s):  
Kenji Noda ◽  
Satoru Kodama ◽  
Hideaki Mabuchi ◽  
Kanako Noda ◽  
Masashi Suzuki
Keyword(s):  
Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Fungal Sinusitis ◽  
Invasive Fungal Sinusitis

Efficacy of Different Modalities of Treatment in Management of Different Types of Fungal Sinusits

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
AbdElhamid AbdElhamid Al-Nashar ◽  
Waleed Farag Ezzat ◽  
Mohammed Abdelaleem Mohammed ◽  
Mohammed Al-Shahat Ibrahim Al-Bahet
Keyword(s):  
Antifungal Therapy ◽  
Endoscopic Sinus Surgery ◽  
Endoscopic Technique ◽  
Sinus Surgery ◽  
Fungal Sinusitis ◽  
Fungal Ball ◽  
Non Invasive ◽  
Invasive Fungal Sinusitis ◽  
Canine Fossa ◽  
Different Types

Abstract Background Fungal sinusitis is generally classified into invasive and non invasive fungal sinusitis based on histological features, invasive fungal sinusitis divided into acute, chronic and chronic granulomatous invasive fungal sinusitis. While non invasive fungal sinusitis include saprophytic fungal infestation, fungal ball, and fungus-related eosinophilic. Distinguishing invasive disease from noninvasive disease is important because the treatment and prognosis are different for each. AIM A systemic review of effective and safe method in management of different types of fungal sinusitis either by medical or surgical approaches or even combined. Be up to date with the different upcoming new modalities. Methodology A meta-analysis study is done to evaluate the medical and surgical outcomes of patients with invasive and noninvasive Fungal Sinusits. Results Finally, forty-five studies were included in the present systematic review and metaanalysis. Fifteen included studies (No = 539 patients) assessed different modalities for management of fungal ball, via classic endoscopic technique, Canine-fossa approach, gauze technique and osteoplastic approach for FB of the maxillary sinus. The results showed that functional endoscopic sinus surgery has led to success rate of 98.1%. Twenty included studies (No = 806 patients) have assessed the efficacy and safety of different modalities for the management of allergic fungal sinusitis via,Endoscopic Sinus Surgery, Post-ESS Systemic steroids, Antifungals and immunotherapy. The results showed that ESS represents the firstline management strategy of AFRS, followed by aggressive medical therapies, the recurrence rate after postoperative steroids was 20.6%, postoperative antifungals was 40% and after immunotherapy was 9.1%. Ten studies (No = 327 patients) for Invasive Fungal Sinusitis.the results showed that combination of systematic antifungal therapy and aggressive surgical debridement are the treatment of choice. Conclusion FESS is the treatment of choice of fungal ball via classic endoscopic technique, Canine-fossa approach, gauze technique and osteoplastic approach. AFS treatment consists of surgical extirpation of the allergic mucin and polyps with maintenance of adequate sinus drainage followed by medical therapy consists of topical steroids, anti fungal therapy, Immunotherapy, and systemic corticosteroids. Treatment of invasive fungal sinusitis includes surgical resection of necrotic tissues, systemic antifungal therapy and reversal of immune dysfunction.

scholarly journals Computed Tomography of Paranasal Sinus Pathologies with Functional Endoscopic Sinus Surgery/Nasal Endoscopy Correlation

2016 ◽  
Vol 9 (1) ◽  
pp. 1-5
Author(s):  
Kiran Rao
Keyword(s):  
Computed Tomography ◽  
Paranasal Sinus ◽  
Endoscopic Sinus Surgery ◽  
Disease Incidence ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Nasal Endoscopy ◽  
Lower Sensitivity ◽  
Fungal Sinusitis ◽  
Diagnostic Modality

ABSTRACT A prospective study was conducted on 50 patients at the SGRD Institute of Medical Sciences and Research, Amritsar, suffering from paranasal sinus disease correlating the findings of computed tomography (CT) using Siemens SOMATOM Emotion 6 slice CT machine with diagnostic nasal endoscopy or functional endoscopic sinus surgery (FESS). Infection of the paranasal sinuses is very common. Surgical clearance of these chronically infected sinuses while maintaining their ventilation and drainage is the treatment of choice. To achieve this goal, there should be some diagnostic modality that guides us toward the exact diagnosis and safe intervention. Computed tomography proves to be the most reliable method of preoperative assessment of patients undergoing FESS as it delineates the extent of the disease and defines any anatomical variants and relationship of the sinuses with the surrounding important structures, thus providing a road map for sinus surgery. In our study, most patients were in the 3rd and 4th decades of their life with equal disease incidence in males and females. The most common sinus involved was anterior ethmoid sinus, while sphenoid sinus was the least commonly involved. The most common pattern of inflammation was sinonasal polyposis followed by osteomeatal unit pattern. On correlating CT diagnosis with the final diagnosis, chronic sinusitis had 86% sensitivity and 96.5% specificity. Polyps had sensitivity of 96.15% and specificity of 95.83%. Again for fungal sinusitis, CT had a lower sensitivity of 71.4% and specificity of 93.02%. For diagnosing benign and malignant lesions, CT had 100% sensitivity and specificity, which could be due to the small number of masses evaluated. This study proved that CT is the modality of choice for evaluating and planning the management of symptomatic patients of paranasal sinus pathologies. How to cite this article Rao K. Computed Tomography of Paranasal Sinus Pathologies with Functional Endoscopic Sinus Surgery/Nasal Endoscopy Correlation. Clin Rhinol An Int J 2016;9(1):1-5.

Primary Paranasal Aspergillus Granuloma: Case Report and Review of the Literature

2002 ◽  
Vol 16 (3) ◽  
pp. 165-168 ◽  
Author(s):  
John Currens ◽  
Patricia S. Hutcheson ◽  
Raymond G. Slavin ◽  
Martin J. Citardi
Keyword(s):  
United States ◽  
Chronic Infection ◽  
Plasma Cells ◽  
Giant Cells ◽  
The United States ◽  
Fungal Sinusitis ◽  
Review Of The Literature ◽  
Invasive Fungal Sinusitis ◽  
First Case ◽  
Chronic Invasive

Background Primary paranasal aspergillus granuloma (PPAG) is a slowly progressive chronic infection of the sinus extending beyond the confines of the sinus. It has been reported only in patients from the Sudan and India. Microscopically, it differs from chronic invasive fungal sinusitis in that there are pseudotubercles containing giant cells, histiocytes, lymphocytes, plasma cells, newly formed capillaries, eosinophils, and Aspergillus fungal elements. Conclusion We describe the first case of PPAG in the United States in an immunocompetent nonatopic woman who had never left Missouri.

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