Low Levels of Hepatocyte‐Specific Methylation in cfDNA are a Strong Negative Predictor for Acute T‐cell Mediated Rejection requiring Treatment following Liver Transplantation

2021 ◽  
Author(s):  
Daniel R.A. Cox ◽  
Nicholas Low ◽  
Su Kah Goh ◽  
Eunice Lee ◽  
Angela Vago ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
T Cell ◽  
Low Levels ◽  
Negative Predictor

SAT-440-Molecular fingerprint of T cell-mediated and antibody-mediated rejection after human liver transplantation

2019 ◽  
Vol 70 (1) ◽  
pp. e830
Author(s):  
Anne Höfer ◽  
Danny Jonigk ◽  
Björn Hartleben ◽  
Robert Geffers ◽  
Murielle Verboom ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
T Cell ◽  
Human Liver ◽  
Molecular Fingerprint ◽  
Antibody Mediated Rejection

scholarly journals Differential Effects of IL-2 and IL-6 on the Development of Three Distinct Precursor T-Cell Populations in the Thymus

1990 ◽  
Vol 1 (2) ◽  
pp. 77-84 ◽  
Author(s):  
Naoko Nakano ◽  
Hitoshi Kikutani ◽  
Tadamitsu Kishimoto
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Bone Marrow Cells ◽  
Cell Populations ◽  
High Dose ◽  
Transfer System ◽  
Cell Sorter ◽  
Lineage Markers ◽  
Low Levels ◽  
Normal Differentiation

Three distinct T-cell precursors: bone marrow cells that express low levels of the Thy-1 antigen but no lineage markers (Thy-1-lo/BM); CD4-, CD8-, and CD3-thymocytes that express low levels of the Thy-1 antigen (Thy-1-lo/Thym); and CD4-, CD8-, and CD3-thymocytes that express high levels of the Thy-1 antigen and the IL-2 Rαchain (Thy-1+/ IL2R+) were isolated by fluorescence-activated cell sorter (FACS). These three populations expanded with different kinetics in the thymus of irradiated recipient mice after intrathymic transfer. When a high dose of human recombinant IL-2 (r-IL-2) or human recombinant IL-6 (r-IL-6) was administered, r-IL-6 accelerated donor Thy-1+/IL2R+to differentiate, whereas r-IL-2 blocked normal differentiation and expansion of donor Thy-1-lo/Thym, but did not show any significant effect on donor Thy-1+/IL2R+. Neither r-IL-2 nor r-IL-6 worked directly on donor Thy-1-lo/BM in this transfer system.

scholarly journals HIV-specific CD8 T cells express low levels of IL-7Rα: Implications for HIV-specific T cell memory

Virology ◽  
2006 ◽  
Vol 353 (2) ◽  
pp. 366-373 ◽  
Author(s):  
E. John Wherry ◽  
Cheryl L. Day ◽  
Rika Draenert ◽  
Joseph D. Miller ◽  
Photini Kiepiela ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
T Cell Memory ◽  
Cell Memory ◽  
Low Levels

MicroRNAs 155‐5p, 122‐5p, and 181a‐5p Identify Patients With Graft Dysfunction Due to T Cell–Mediated Rejection After Liver Transplantation

2020 ◽  
Vol 26 (10) ◽  
pp. 1275-1286 ◽  
Author(s):  
Pablo Ruiz ◽  
Olga Millán ◽  
Jose Ríos ◽  
Alba Díaz ◽  
Lydia Sastre ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
T Cell ◽  
Graft Dysfunction

Number of Antibody-verified Eplet in HLA-C Locus as an Independent Factor of T-cell–Mediated Rejection After Liver Transplantation

2020 ◽  
Vol 104 (3) ◽  
pp. 562-567
Author(s):  
Sandra Guiral ◽  
David San Segundo ◽  
Juan Irure ◽  
Fernando Casafont ◽  
Jose Ignacio Fortea ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
T Cell ◽  
Independent Factor

scholarly journals Spontaneous clearance of chronic hepatitis C after liver transplantation: Are hepatitis C virus-specific T cell responses the clue?

2008 ◽  
Vol 14 (8) ◽  
pp. 1225-1227 ◽  
Author(s):  
P. V. Suneetha ◽  
Ingmar Mederacke ◽  
Albert Heim ◽  
Murat Bastürk ◽  
Markus Cornberg ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Chronic Hepatitis C ◽  
T Cell Responses ◽  
Spontaneous Clearance ◽  
Cell Responses

Diagnostic value of peripheral blood T-cell activation and soluble IL-2 receptor for acute rejection in liver transplantation

2002 ◽  
Vol 320 (1-2) ◽  
pp. 69-78 ◽  
Author(s):  
Andreas Lun ◽  
Mi Young Cho ◽  
Christian Müller ◽  
Gerhard Staffa ◽  
Wolf Otto Bechstein ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
T Cell ◽  
Acute Rejection ◽  
T Cell Activation ◽  
Peripheral Blood ◽  
Cell Activation ◽  
Diagnostic Value

scholarly journals CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 ◽  
Vol 182 (2) ◽  
pp. 459-465 ◽  
Author(s):  
M F Krummel ◽  
J P Allison
Keyword(s):  
T Cells ◽  
T Cell ◽  
Costimulatory Molecule ◽  
Surface Glycoprotein ◽  
T Cell Proliferation ◽  
Cell Surface Glycoprotein ◽  
Costimulatory Signals ◽  
Low Levels ◽  
Opposing Effects ◽  
Antigen Presenting

The importance of the B7/CD28/CTLA-4 molecules has been established in studies of antigen-presenting cell-derived B7 and its interaction with the T cell costimulatory molecule CD28. CTLA-4, a T cell surface glycoprotein that is related to CD28, can also interact with B7-1 and B7-2. However, less is known about the function of CTLA-4, which is expressed at highest levels after activation. We have generated an antibody to CTLA-4 to investigate the consequences of engagement of this molecule in a carefully defined system using highly purified T cells. We show here that the presence of low levels of B7-2 on freshly explanted T cells can partially inhibit T cell proliferation, and this inhibition is mediated by interactions with CTLA-4. Cross-linking of CTLA-4 together with the TCR and CD28 strongly inhibits proliferation and IL-2 secretion by T cells. Finally, results show that CD28 and CTLA-4 deliver opposing signals that appear to be integrated by the T cell in determining the response to activation. These data strongly suggest that the outcome of T cell antigen receptor stimulation is regulated by CD28 costimulatory signals, as well as inhibitory signals derived from CTLA-4.

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