Injectable Hydrogel for Sustained Protein Release by Salt-Induced Association of Hyaluronic Acid Nanogel

2012 ◽  
Vol 12 (4) ◽  
pp. 475-483 ◽  
Author(s):  
Takashi Nakai ◽  
Tai Hirakura ◽  
Yuji Sakurai ◽  
Tsuyoshi Shimoboji ◽  
Masaki Ishigai ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Protein Release ◽  
Injectable Hydrogel ◽  
Sustained Protein Release

scholarly journals How Poloxamer Addition in Hyaluronic-Acid-Decorated Biodegradable Microparticles Affects Polymer Degradation and Protein Release Kinetics

2021 ◽  
Vol 11 (16) ◽  
pp. 7567
Author(s):  
Teresa Silvestri ◽  
Barbara Immirzi ◽  
Giovanni Dal Poggetto ◽  
Paola Di Donato ◽  
Valentina Mollo ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Degradation Rate ◽  
Degradation Kinetics ◽  
Dynamic Balance ◽  
Release Kinetics ◽  
Slight Modification ◽  
Gel Permeation Chromatography ◽  
Protein Release ◽  
Polymeric Microparticles ◽  
Biodegradable Microparticles

Polymeric microparticles (MPs) designed for the intravitreal administration of therapeutic proteins result in a prolonged half-life in the vitreous and can delay or discourage the onset of adverse effects inevitably related to this route of administration. Hence, here we designed MPs composed of a polymeric blend based on poly(lactic-co-glycolic) acid and poloxamers, externally decorated with hyaluronic acid. The MPs are intended for intravitreal administration of bovine serum albumin. In detail, a systematic formulative study aiming to shed light on the complex relationship between protein release rate and MP degradation rate was carried out by means of calorimetric and gel permeation chromatography analyses. We found out that poloxamer addition caused a compact MP matrix, which led to a slight modification of the degradation kinetics and a reduction in the initial BSA initial release, which is of the utmost importance to ensure a relatively regular BSA release. It must also be underlined that for acid-labile molecules such as proteins, the poloxamer’s presence induced complex and hardly predictable effects on MP degradation/protein release, due to the dynamic balance between the time-evolving hydrophilicity of MPs and the influence of poloxamers themselves on the PLGA degradation rate.

Injectable Acylhydrazone‐linked RAFT Polymer Hydrogels for Sustained Protein Release and Cell Encapsulation

2021 ◽  
pp. 2101284
Author(s):  
Fang‐Yi Lin ◽  
Nathan H. Dimmitt ◽  
Mariana Moraes de Lima Perini ◽  
Jiliang Li ◽  
Chien‐Chi Lin
Keyword(s):  
Cell Encapsulation ◽  
Protein Release ◽  
Polymer Hydrogels ◽  
Sustained Protein Release

Regeneration of ischemic heart using hyaluronic acid-based injectable hydrogel

2009 ◽  
Vol 91B (1) ◽  
pp. 163-171 ◽  
Author(s):  
So Jeong Yoon ◽  
Yong Hu Fang ◽  
Choon Hak Lim ◽  
Bum Shik Kim ◽  
Ho Sung Son ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Ischemic Heart ◽  
Injectable Hydrogel

Potential application of an injectable hydrogel scaffold loaded with mesenchymal stem cells for treating traumatic brain injury

2018 ◽  
Vol 6 (19) ◽  
pp. 2982-2992 ◽  
Author(s):  
Kun Zhang ◽  
Zhenqing Shi ◽  
Jiankang Zhou ◽  
Qu Xing ◽  
Shanshan Ma ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Brain Injury ◽  
Sodium Alginate ◽  
Potential Application ◽  
Hydrogel Scaffold ◽  
Injectable Hydrogel ◽  
Tissue Scaffold

In this contribution, we developed an injectable hydrogel composed of sodium alginate and hyaluronic acid that acts as a tissue scaffold to create a more optimal microenvironment for the stem cells for potential application of traumatic brain injury implantation.

A rapid crosslinking injectable hydrogel for stem cell delivery, from multifunctional hyperbranched polymers via RAFT homopolymerization of PEGDA

2015 ◽  
Vol 6 (34) ◽  
pp. 6182-6192 ◽  
Author(s):  
Yixiao Dong ◽  
Yue Qin ◽  
Marie Dubaa ◽  
John Killion ◽  
Yongsheng Gao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hyaluronic Acid ◽  
Hyperbranched Polymers ◽  
Cell Delivery ◽  
Injectable Hydrogel ◽  
Stem Cell Delivery

A novel injectable hydrogel for stem cell delivery was prepared from multifunctional hyperbranched polyPEGDA and thiolated hyaluronic acid.

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