A Supramolecular Host-Guest Interaction-mediated Injectable Hydrogel System with Enhanced Stability and Sustained Protein Release

2021 ◽  
Author(s):  
Seung Yong Lee ◽  
Seong Ik Jeon ◽  
Sung Bo Sim ◽  
Youngro Byun ◽  
Cheol-Hee Ahn
Keyword(s):  
Protein Release ◽  
Injectable Hydrogel ◽  
Sustained Protein Release ◽  
Enhanced Stability ◽  
Hydrogel System

Injectable Hydrogel for Sustained Protein Release by Salt-Induced Association of Hyaluronic Acid Nanogel

2012 ◽  
Vol 12 (4) ◽  
pp. 475-483 ◽  
Author(s):  
Takashi Nakai ◽  
Tai Hirakura ◽  
Yuji Sakurai ◽  
Tsuyoshi Shimoboji ◽  
Masaki Ishigai ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Protein Release ◽  
Injectable Hydrogel ◽  
Sustained Protein Release

Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment

2019 ◽  
Vol 7 (10) ◽  
pp. 4195-4207 ◽  
Author(s):  
Thai Minh Duy Le ◽  
Bo-Kyeong Jung ◽  
Yi Li ◽  
Huu Thuy Trang Duong ◽  
Thanh Loc Nguyen ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Temperature Responsive ◽  
Oncolytic Adenoviruses ◽  
Term Delivery ◽  
Physically Crosslinked ◽  
Hydrogel System

A dual pH- and temperature-responsive physically crosslinked and injectable hydrogel system was developed for efficient and long-term delivery of oncolytic adenoviruses (Ads).

Injectable Acylhydrazone‐linked RAFT Polymer Hydrogels for Sustained Protein Release and Cell Encapsulation

2021 ◽  
pp. 2101284
Author(s):  
Fang‐Yi Lin ◽  
Nathan H. Dimmitt ◽  
Mariana Moraes de Lima Perini ◽  
Jiliang Li ◽  
Chien‐Chi Lin
Keyword(s):  
Cell Encapsulation ◽  
Protein Release ◽  
Polymer Hydrogels ◽  
Sustained Protein Release

A novel injectable hydrogel system based on polyampholyte microgels

2017 ◽  
Vol 259 ◽  
pp. e101-e102
Author(s):  
Peijian Sun ◽  
Cong Nie ◽  
Zhihua Gan
Keyword(s):  
Injectable Hydrogel ◽  
Hydrogel System

Metal-chelating affinity hydrogels for sustained protein release

2007 ◽  
Vol 83A (4) ◽  
pp. 954-964 ◽  
Author(s):  
Chien-Chi Lin ◽  
Andrew T. Metters
Keyword(s):  
Protein Release ◽  
Metal Chelating ◽  
Sustained Protein Release

Injectable Fibrin/Polyethylene Oxide Semi-IPN Hydrogel for a Segmental Meniscal Defect Regeneration

2021 ◽  
pp. 036354652199802
Author(s):  
Jin-A Kim ◽  
Young-Hyeon An ◽  
Hyun-Gu Yim ◽  
Woo-Jung Han ◽  
Yong-Beom Park ◽  
...  
Keyword(s):  
Polyethylene Oxide ◽  
Interpenetrating Polymer Network ◽  
Segmental Defect ◽  
Dependent Manner ◽  
Clinical Practices ◽  
Defect Model ◽  
Tissue Quality ◽  
Injectable Hydrogel ◽  
Hydrogel System

Background: Meniscal deficiency from meniscectomy is a common situation in clinical practices. Regeneration of the deficient meniscal portion, however, is still not feasible. Purpose: To develop an injectable hydrogel system consisting of fibrin (Fb) and polyethylene oxide (PEO) and to estimate its clinical potential for treating a segmental defect of the meniscus in a rabbit meniscal defect model. Study Design: Controlled laboratory study. Methods: The Fb/PEO hydrogel was fabricated by extruding 100 mg·mL-1 of fibrinogen solution and 2,500 U·mL-1 of thrombin solution containing 100 mg·mL-1 of PEO through a dual-syringe system. The hydrogels were characterized by rheological analysis and biodegradation tests. The meniscal defects of New Zealand White male rabbits were generated by removing 60% of the medial meniscus from the anterior side. The removed portion included the central portion. The Fb/PEO hydrogel was injected into the meniscal defect of the experimental knee through the joint space between the femoral condyle and tibial plateau at the anterior knee without a skin incision. The entire medial menisci from both knees of each rabbit were collected and photographed before placement in formalin for histological processing. Hematoxylin and eosin, safranin O, and immunohistochemical staining for type II collagen was performed. The biomechanical property of the regenerated meniscus was evaluated using a universal tensile machine. Results: The Fb/PEO hydrogel was fabricated by an in situ gelation process, and the hydrogel displayed a semi-interpenetrating polymer network structure. We demonstrated that the mechanical properties of Fb-based hydrogels increased in a PEO-dependent manner. Furthermore, the addition of PEO delayed the biodegradation of the hydrogel. Our in vivo data demonstrated that, as compared with Fb hydrogel, Fb/PEO hydrogel injection into the meniscectomy model showed improved tissue regeneration. The regenerated meniscal tissue by Fb/PEO hydrogel showed enhanced tissue quality, which was supported by the histological and biomechanical properties. Conclusion: The Fb/PEO hydrogel had an effective tissue-regenerative ability through injection into the in vivo rabbit meniscal defect model. Clinical Relevance: This injectable hydrogel system can promote meniscal repair and be readily utilized in clinical application.

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