Factors Affecting Secondary and Supramolecular Structures of Self‐Assembling Peptide Nanocarriers

2021 ◽  
pp. 2100347
Author(s):  
Megan E. Pitz ◽  
Alexandra M. Nukovic ◽  
Margaret A. Elpers ◽  
Angela A. Alexander‐Bryant
Keyword(s):  
Supramolecular Structures ◽  
Factors Affecting ◽  
Self Assembling

Factors Affecting Molecular Self-Assembly and Its Mechanism

2012 ◽  
Vol 9 (1) ◽  
pp. 43 ◽  
Author(s):  
Hueyling Tan
Keyword(s):  
Self Assembly ◽  
Building Blocks ◽  
Molecular Engineering ◽  
Molecular Structures ◽  
Polymer Science ◽  
New Approach ◽  
Factors Affecting ◽  
Dna Structures ◽  
Self Assembling ◽  
Wide Range

Molecular self-assembly is ubiquitous in nature and has emerged as a new approach to produce new materials in chemistry, engineering, nanotechnology, polymer science and materials. Molecular self-assembly has been attracting increasing interest from the scientific community in recent years due to its importance in understanding biology and a variety of diseases at the molecular level. In the last few years, considerable advances have been made in the use ofpeptides as building blocks to produce biological materials for wide range of applications, including fabricating novel supra-molecular structures and scaffolding for tissue repair. The study ofbiological self-assembly systems represents a significant advancement in molecular engineering and is a rapidly growing scientific and engineering field that crosses the boundaries ofexisting disciplines. Many self-assembling systems are rangefrom bi- andtri-block copolymers to DNA structures as well as simple and complex proteins andpeptides. The ultimate goal is to harness molecular self-assembly such that design andcontrol ofbottom-up processes is achieved thereby enabling exploitation of structures developed at the meso- and macro-scopic scale for the purposes oflife and non-life science applications. Such aspirations can be achievedthrough understanding thefundamental principles behind the selforganisation and self-synthesis processes exhibited by biological systems.

Self-assembling of p-tert-butylcalix[4]arene into supramolecular structures using transition-metal derivatization

1996 ◽  
pp. 119 ◽  
Author(s):  
Antonio Zanotti-Gerosa ◽  
Euro Solari ◽  
Luca Giannini ◽  
Carlo Floriani ◽  
Angiola Chiesi-Villa ◽  
...  
Keyword(s):  
Transition Metal ◽  
Supramolecular Structures ◽  
Self Assembling

scholarly journals Protein Supramolecular Structures: From Self-Assembly to Nanovaccine Design

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 1008 ◽  
Author(s):  
Ximena Zottig ◽  
Mélanie Côté-Cyr ◽  
Dominic Arpin ◽  
Denis Archambault ◽  
Steve Bourgault
Keyword(s):  
Immune Responses ◽  
Self Assembly ◽  
Molecular Level ◽  
Supramolecular Structures ◽  
Atomic Scale ◽  
Supramolecular Interactions ◽  
Protein Assemblies ◽  
Adaptive Immune ◽  
Self Assembling ◽  
Molecular Specificity

Life-inspired protein supramolecular assemblies have recently attracted considerable attention for the development of next-generation vaccines to fight against infectious diseases, as well as autoimmune diseases and cancer. Protein self-assembly enables atomic scale precision over the final architecture, with a remarkable diversity of structures and functionalities. Self-assembling protein nanovaccines are associated with numerous advantages, including biocompatibility, stability, molecular specificity and multivalency. Owing to their nanoscale size, proteinaceous nature, symmetrical organization and repetitive antigen display, protein assemblies closely mimic most invading pathogens, serving as danger signals for the immune system. Elucidating how the structural and physicochemical properties of the assemblies modulate the potency and the polarization of the immune responses is critical for bottom-up design of vaccines. In this context, this review briefly covers the fundamentals of supramolecular interactions involved in protein self-assembly and presents the strategies to design and functionalize these assemblies. Examples of advanced nanovaccines are presented, and properties of protein supramolecular structures enabling modulation of the immune responses are discussed. Combining the understanding of the self-assembly process at the molecular level with knowledge regarding the activation of the innate and adaptive immune responses will support the design of safe and effective nanovaccines.

scholarly journals Diverse supramolecular structures formed by self‐assembling proteins of the B acillus subtilis spore coat

2015 ◽  
Vol 97 (2) ◽  
pp. 347-359 ◽  
Author(s):  
Shuo Jiang ◽  
Qiang Wan ◽  
Daniela Krajcikova ◽  
Jilin Tang ◽  
Svetomir B. Tzokov ◽  
...  
Keyword(s):  
Supramolecular Structures ◽  
Spore Coat ◽  
Subtilis Spore ◽  
Self Assembling

Lead(II) supramolecular structures formed through a cooperative influence of the hydrazinecarbothioamide derived and ancillary ligands

CrystEngComm ◽  
2021 ◽  
Author(s):  
Isabel Garcia-Santos ◽  
Alfonso Castineiras ◽  
Ghodrat Mahmoudi ◽  
Maria G. Babashkina ◽  
Ennio Zangrando ◽  
...  
Keyword(s):  
Coordination Compounds ◽  
Supramolecular Structures ◽  
Ancillary Ligands ◽  
Self Assembling

In this work we report on new heteroleptic coordination compounds [Pb2(LI)2](NO3)2∙2MeOH (1), [Pb2(LII)2](NO3)2 (2), [Pb2(LIII)2](NO3)2∙MeOH∙H2O (3) and [Pb2(LIII)2(H2O)](NCS)2 (4), which were obtained through self-assembling of 2-(amino(pyridin-2-yl)methylene)hydrazine-1-carbothioamide (HLI), 2-(amino(pyrazin-2-yl)methylene)hydrazine-1-carbothioamide (HLII) or...

scholarly journals β-Cyclodextrin- and adamantyl-substituted poly(acrylate) self-assembling aqueous networks designed for controlled complexation and release of small molecules

2017 ◽  
Vol 13 ◽  
pp. 1879-1892 ◽  
Author(s):  
Liang Yan ◽  
Duc-Truc Pham ◽  
Philip Clements ◽  
Stephen F Lincoln ◽  
Jie Wang ◽  
...  
Keyword(s):  
Methyl Orange ◽  
Small Molecules ◽  
Controlled Drug Release ◽  
Methyl Red ◽  
Dialysis Membrane ◽  
Factors Affecting ◽  
H Nmr ◽  
Self Assembling ◽  
Vis Spectroscopy ◽  
Insight Into

Three aqueous self-assembling poly(acrylate) networks have been designed to gain insight into the factors controlling the complexation and release of small molecules within them. These networks are formed between 8.8% 6A-(2-aminoethyl)amino-6A-deoxy-6A-β-cyclodextrin, β-CDen, randomly substituted poly(acrylate), PAAβ-CDen, and one of the 3.3% 1-(2-aminoethyl)amidoadamantyl, ADen, 3.0% 1-(6-aminohexyl)amidoadamantyl, ADhn, or 2.9% 1-(12-aminododecyl)amidoadamantyl, ADddn, randomly substituted poly(acrylate)s, PAAADen, PAAADhn and PAAADddn, respectively, such that the ratio of β-CDen to adamantyl substituents is ca. 3:1. The variation of the characteristics of the complexation of the dyes methyl red, methyl orange and ethyl orange in these three networks and by β-cyclodextrin, β-CD, and PAAβ-CDen alone provides insight into the factors affecting dye complexation. The rates of release of the dyes through a dialysis membrane from the three aqueous networks show a high dependence on host–guest complexation between the β-CDen substituents and the dyes as well as the structure and the viscosity of the network as shown by ITC, 1H NMR and UV–vis spectroscopy, and rheological studies. Such networks potentially form a basis for the design of controlled drug release systems.

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