In the title compound (3-(2-chlorophenyl)-5-tosyl-1,3,3a,4,5,9b-hexahydroisoxazolo[4,3-c]quinolin-3a-yl)methanamine (3-CPTHIQM), the Thorpe–Ingold effect causes the S atom's tetrahedral geometry to be deformed, with O-S-O and N-S-C angles diverging from ideal tetrahedral values. The crystal packing features C—H⋯O hydrogen-bond inter¬actions.The supramolecular interactions were confirmed and quantified using Hirshfeld surface analysis. Quantum chemical calculations of sulfonamide are calculated at DFT/B3LYP/6-311++G(d,p) basis set. The NLO properties were calculated at the same level of theory. Furthermore, frontier molecular orbitals (FMOs) and molecular electrostatic potential (MEP) surfaces were calculated and analyzed in detail. In a molecular docking study, the investigated sulfonamide compound is evaluated as a new potential cancer inhibitor.