Size‐Stable Supramolecular Hyperbranched Polymer Vesicles for Redox‐Triggered Double‐Drug Release

2018 ◽  
Vol 220 (3) ◽  
pp. 1800467 ◽  
Author(s):  
Guowen Du ◽  
Shuodong Wang ◽  
Hongxing Yuan ◽  
Jingxia Wang ◽  
Yanli Song ◽  
...  
Keyword(s):  
Drug Release ◽  
Hyperbranched Polymer ◽  
Polymer Vesicles

Hyperbranched polymer vesicles: from self-assembly, characterization, mechanisms, and properties to applications

2015 ◽  
Vol 44 (12) ◽  
pp. 3874-3889 ◽  
Author(s):  
Wenfeng Jiang ◽  
Yongfeng Zhou ◽  
Deyue Yan
Keyword(s):  
Self Assembly ◽  
Hyperbranched Polymer ◽  
Polymer Vesicles

This tutorial review summarizes the first 10 years of work on hyperbranched polymer vesicles from syntheses, self-assembly, and properties to applications.

Preparations of hyperbranched polymer nano micelles and the pH/redox controlled drug release behaviors

2017 ◽  
Vol 79 ◽  
pp. 116-122 ◽  
Author(s):  
Liping Zhang ◽  
Yamin Zhou ◽  
Gang Shi ◽  
Xinxin Sang ◽  
Caihua Ni
Keyword(s):  
Drug Release ◽  
Hyperbranched Polymer ◽  
Controlled Drug Release

Polymer vesicles assembled from ALG- g -PNIPAM and β -cyclodextrin through inclusion complexation for drug release

2015 ◽  
Vol 213 ◽  
pp. e35 ◽  
Author(s):  
Guiying Li ◽  
Minyi Qi ◽  
Nana Yu ◽  
Qian Tao
Keyword(s):  
Drug Release ◽  
Inclusion Complexation ◽  
Polymer Vesicles

Synthesis of monodisperse nanocolloidal microspheres with controlled size by vesicle bilayer templating

2014 ◽  
Vol 50 (55) ◽  
pp. 7363-7366 ◽  
Author(s):  
Tong Huang ◽  
Xiaohua Huang ◽  
Xiaoyi Sun ◽  
Yongfeng Zhou ◽  
Yongping Bai ◽  
...  
Keyword(s):  
Hyperbranched Polymer ◽  
Colloidal Particles ◽  
Mass Scale ◽  
Polymer Vesicles ◽  
Controllable Size

Uniform PS colloidal particles with controllable size ranging from 60 to 150 nm were prepared on a mass scale by using the bilayers of hyperbranched polymer vesicles as templates.

Intelligent CO2- and photo-dual-responsive polymer vesicles with tunable wall thickness

2019 ◽  
Vol 10 (13) ◽  
pp. 1610-1618 ◽  
Author(s):  
Jia Tian ◽  
Baoxuan Huang ◽  
Chao Xiao ◽  
Philipp Vana
Keyword(s):  
Drug Release ◽  
Wall Thickness ◽  
Dual Responsive ◽  
Polymer Vesicles ◽  
Responsive Polymer

CO2- and photo-dual-responsive polymer vesicles with tunable wall thickness were explored and used as a potential “smart” platform for drug release.

Tracing drug release process with dual-modal hyperbranched polymer-gold nanoparticle complexes

2016 ◽  
Vol 59 (12) ◽  
pp. 1600-1608 ◽  
Author(s):  
Yuanyuan Zhuang ◽  
Dali Wang ◽  
Chunhui Yin ◽  
Hongping Deng ◽  
Mo Sun ◽  
...  
Keyword(s):  
Drug Release ◽  
Gold Nanoparticle ◽  
Hyperbranched Polymer ◽  
Release Process

Multifunctional hybrid aerogels: hyperbranched polymer-trapped mesoporous silica nanoparticles for sustained and prolonged drug release

Nanoscale ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 1704-1715 ◽  
Author(s):  
Heveline D. M. Follmann ◽  
Osvaldo N. Oliveira ◽  
Danielle Lazarin-Bidóia ◽  
Celso V. Nakamura ◽  
Xiaoxi Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Hyperbranched Polymer ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Systems ◽  
Hybrid Aerogels ◽  
Prolonged Drug Release

Aerogels comprising hyperbranched polymers containing mesoporous silica nanoparticles are synthesized and demonstrated to serve as outstanding drug delivery systems.

Modified drug release of poloxamer matrix by including water-soluble and water-insoluble polymer

2009 ◽  
Vol 00 (00) ◽  
pp. 090911111149010-8
Author(s):  
Y.M. Gonzalez ◽  
E.S. Ghaly
Keyword(s):  
Drug Release ◽  
Water Soluble ◽  
Insoluble Polymer

Formulation, Design and Development of Niosome Based Topical Gel for Skin Cancer

2017 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Skin Cancer ◽  
Drug Release ◽  
Hemorrhagic Cystitis ◽  
The Body ◽  
Cancer Drug ◽  
Inversion Method ◽  
Body Parts ◽  
Basal Cells ◽  
Formulation Design ◽  
Topical Gel

Melanoma is the most dangerous type of skin cancer in which mostly damaged unpaired DNA starts mutating abnormally and staged an unprecedented proliferation of epithelial skin to form a malignant tumor. In epidemics of skin, pigment-forming melanocytes of basal cells start depleting and form uneven black or brown moles. Melanoma can further spread all over the body parts and could become hard to detect. In USA Melanoma kills an estimated 10,130 people annually. This challenge can be succumbed by using the certain anti-cancer drug. In this study design, cyclophosphamide were used as a model drug. But it has own limitation like mild to moderate use may cause severe cytopenia, hemorrhagic cystitis, neutropenia, alopecia and GI disturbance. This is a promising challenge, which is caused due to the increasing in plasma drug concentration above therapeutic level and due to no rate limiting steps involved in formulation design. In this study, we tried to modify drug release up to threefold and extended the release of drug by preparing and designing niosome based topical gel. In the presence of Dichloromethane, Span60 and cholesterol, the initial niosomes were prepared using vacuum evaporator. The optimum percentage drug entrapment efficacy, zeta potential, particle size was found to be 72.16%, 6.19mV, 1.67µm.Prepared niosomes were further characterized using TEM analyzer. The optimum batch of niosomes was selected and incorporated into topical gel preparation. Cold inversion method and Poloxamer -188 and HPMC as core polymers, were used to prepare cyclophosphamide niosome based topical gel. The formula was designed using Design expert 7.0.0 software and Box-Behnken Design model was selected. Almost all the evaluation parameters were studied and reported. The MTT shows good % cell growth inhibition by prepared niosome based gel against of A375 cell line. The drug release was extended up to 20th hours. Further as per ICH Q1A (R2), guideline 6 month stability studies were performed. The results were satisfactory and indicating a good formulation approach design was achieved for Melanoma treatment.

Effects of release modifier on Carvedilol release from Kollidon SR based matrix

2012 ◽  
Vol 1 (8) ◽  
pp. 186 ◽  
Author(s):  
Urmi Das ◽  
Mohammad Salim Hossain
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Microcrystalline Cellulose ◽  
Matrix Tablets ◽  
Dissolution Time ◽  
Release Mechanism ◽  
Matrix Tablet ◽  
Weight Variation ◽  
The Matrix ◽  
Tablet Formulations

<p>Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.</p><p>DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.11095">http://dx.doi.org/10.3329/icpj.v1i8.11095</a></p> <p>International Current Pharmaceutical Journal 2012, 1(8): 186-192</p>

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