Hyperbranched polymer vesicles: from self-assembly, characterization, mechanisms, and properties to applications

2015 ◽  
Vol 44 (12) ◽  
pp. 3874-3889 ◽  
Author(s):  
Wenfeng Jiang ◽  
Yongfeng Zhou ◽  
Deyue Yan
Keyword(s):  
Self Assembly ◽  
Hyperbranched Polymer ◽  
Polymer Vesicles

This tutorial review summarizes the first 10 years of work on hyperbranched polymer vesicles from syntheses, self-assembly, and properties to applications.

Flow Chemistry Controls Both Self-Assembly and the Entrapped Oscillatory Cargo in Belousov-Zhabotinsky Driven Polymerization-Induced Self-Assembly

2019 ◽  
Author(s):  
Liman Hou ◽  
Marta Dueñas-Diez ◽  
Rohit Srivastava ◽  
Juan Perez-Mercader
Keyword(s):  
Self Assembly ◽  
Flow Chemistry ◽  
Batch Reactors ◽  
Equilibrium Conditions ◽  
One Pot ◽  
Bz Reaction ◽  
Polymer Vesicles ◽  
Simultaneous Control ◽  
Novel Method ◽  
Continuously Stirred Tank Reactor

<p></p><p>Belousov-Zhabotinsky (B-Z) reaction driven polymerization-induced self-assembly (PISA), or B-Z PISA, is a novel method for the autonomous one-pot synthesis of polymer vesicles from a macroCTA (macro chain transfer agent) and monomer solution (“soup”) containing the above and the BZ reaction components. In it, the polymerization is driven (and controlled) by periodically generated radicals generated in the oscillations of the B-Z reaction. These are inhibitor/activator radicals for the polymerization. Until now B-Z PISA has only been carried out in batch reactors. In this manuscript we present the results of running the system using a continuously stirred tank reactor (CSTR) configuration which offers some interesting advantages.Indeed, by controlling the CSTR parameters we achieve reproducible and simultaneous control of the PISA process and of the properties of the oscillatory cargo encapsulated in the resulting vesicles. Furthermore, the use of flow chemistry enables a more precise morphology control and chemical cargo tuning. Finally, in the context of biomimetic applications a CSTR operation mimics more closely the open non-equilibrium conditions of living systems and their surrounding environments.</p><p></p>

On-demand shape transformation of polymer vesicles via site-specific isomerization of hydrazone photoswitches in monodisperse hydrophobic oligomers

2021 ◽  
Author(s):  
Valene Wang ◽  
Jiwon Kim ◽  
Junyoung Kim ◽  
Seul Woo Lee ◽  
Kyoung Taek Kim
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Conformational Change ◽  
Self Assembly ◽  
Shape Control ◽  
Shape Transformation ◽  
Site Specific ◽  
On Demand ◽  
Polymer Vesicles

The shape control of nanostructures formed by the solution self-assembly of block copolymers is of significance for drug delivery. In particular, site-specific perturbation resulting in the conformational change of the...

Size‐Stable Supramolecular Hyperbranched Polymer Vesicles for Redox‐Triggered Double‐Drug Release

2018 ◽  
Vol 220 (3) ◽  
pp. 1800467 ◽  
Author(s):  
Guowen Du ◽  
Shuodong Wang ◽  
Hongxing Yuan ◽  
Jingxia Wang ◽  
Yanli Song ◽  
...  
Keyword(s):  
Drug Release ◽  
Hyperbranched Polymer ◽  
Polymer Vesicles

scholarly journals Confinement of Therapeutic Enzymes in Selectively Permeable Polymer Vesicles by Polymerization-Induced Self-Assembly (PISA) Reduces Antibody Binding and Proteolytic Susceptibility

2018 ◽  
Vol 4 (6) ◽  
pp. 718-723 ◽  
Author(s):  
Lewis D. Blackman ◽  
Spyridon Varlas ◽  
Maria C. Arno ◽  
Zachary H. Houston ◽  
Nicholas L. Fletcher ◽  
...  
Keyword(s):  
Self Assembly ◽  
Antibody Binding ◽  
Polymer Vesicles ◽  
Permeable Polymer ◽  
Therapeutic Enzymes

scholarly journals Aqueous interfacial gels assembled from small molecule supramolecular polymers

2017 ◽  
Vol 8 (2) ◽  
pp. 1350-1355 ◽  
Author(s):  
Alexander S. Groombridge ◽  
Aniello Palma ◽  
Richard M. Parker ◽  
Chris Abell ◽  
Oren A. Scherman
Keyword(s):  
Small Molecules ◽  
Small Molecule ◽  
Self Assembly ◽  
Hyperbranched Polymer ◽  
Soft Matter ◽  
Supramolecular Polymers ◽  
Supramolecular Network ◽  
Self Healing ◽  
Liquid Interfaces ◽  
Stimuli Responsive

The successful self-assembly of a stimuli-responsive aqueous supramolecular hyperbranched polymer from small molecules and the macrocyclic host cucurbit[8]uril (CB[8]) is reported. This self-healing supramolecular network can act as a soft matter barrier at liquid–liquid interfaces.

scholarly journals Tuning Size and Morphology of mPEG-b-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2572
Author(s):  
Jaleesa Bresseleers ◽  
Mahsa Bagheri ◽  
Coralie Lebleu ◽  
Sébastien Lecommandoux ◽  
Olivier Sandre ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Size Difference ◽  
Flow Rates ◽  
Polymer Vesicles ◽  
Attractive Option ◽  
Self Assembled ◽  
Size And Morphology ◽  
Poly Ethylene ◽  
Careful Design

The careful design of nanoparticles, in terms of size and morphology, is of great importance to developing effective drug delivery systems. The ability to precisely tailor nanoparticles in size and morphology during polymer self-assembly was therefore investigated. Four poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) mPEG-b-p(HPMA-Bz) block copolymers with a fixed hydrophilic block of mPEG 5 kDa and a varying molecular weight of the hydrophobic p(HPMA-Bz) block (A: 17.1, B: 10.0, C: 5.2 and D: 2.7 kDa) were self-assembled into nanoparticles by nanoprecipitation under well-defined flow conditions, using microfluidics, at different concentrations. The nanoparticles from polymer A, increased in size from 55 to 90 nm using lower polymer concentrations and slower flow rates and even polymer vesicles were formed along with micelles. Similarly, nanoparticles from polymer D increased in size from 35 to 70 nm at slower flow rates and also formed vesicles along with micelles, regardless of the used concentration. Differently, polymers B and C mainly self-assembled into micelles at the different applied flow rates with negligible size difference. In conclusion, this study demonstrates that the self-assembly of mPEG-b-p(HPMA-Bz) block copolymers can be easily tailored in size and morphology using microfluidics and is therefore an attractive option for further scaled-up production activities.

Self‐Assembly of Giant Polymer Vesicles by Light‐Assisted Solid Hydration

2019 ◽  
Vol 40 (9) ◽  
pp. 1900027 ◽  
Author(s):  
Lucas Caire da Silva ◽  
Emeline Rideau ◽  
Katharina Landfester
Keyword(s):  
Self Assembly ◽  
Polymer Vesicles

Open-air preparation of cross-linked CO2-responsive polymer vesicles by enzyme-assisted photoinitiated polymerization-induced self-assembly

2019 ◽  
Vol 55 (79) ◽  
pp. 11920-11923 ◽  
Author(s):  
Liangliang Yu ◽  
Yuxuan Zhang ◽  
Xiaocong Dai ◽  
Qin Xu ◽  
Li Zhang ◽  
...  
Keyword(s):  
Self Assembly ◽  
High Solids ◽  
Photoinitiated Polymerization ◽  
Polymer Vesicles ◽  
Responsive Polymer

An open-air strategy via enzyme-assisted photoinitiated polymerization-induced self-assembly (photo-PISA) in water is developed for preparing cross-linked CO2-responsive vesicles at high solids contents.

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