Taxane-induced hedgehog signaling is linked to expansion of breast cancer stem-like populations after chemotherapy

2014 ◽  
Vol 54 (11) ◽  
pp. 1480-1493 ◽  
Author(s):  
Jennifer Sims-Mourtada ◽  
Lynn M. Opdenaker ◽  
Joshua Davis ◽  
Kimberly M. Arnold ◽  
Daniel Flynn
Keyword(s):  
Breast Cancer ◽  
Hedgehog Signaling

Determination of Usnic Acid Responsive miRNAs in Breast Cancer Cell Lines

2019 ◽  
Vol 19 (12) ◽  
pp. 1463-1472 ◽  
Author(s):  
Nil Kiliç ◽  
Yasemin Ö. Islakoğlu ◽  
İlker Büyük ◽  
Bala Gür-Dedeoğlu ◽  
Demet Cansaran-Duman
Keyword(s):  
Breast Cancer ◽  
Hedgehog Signaling ◽  
Treatment Options ◽  
Usnic Acid ◽  
Enrichment Analysis ◽  
Breast Cancer Cell Lines ◽  
Pathway Enrichment Analysis ◽  
Molecular Heterogeneity ◽  
Proliferative Effect ◽  
Mcf 7

Objective: Breast Cancer (BC) is the most common type of cancer diagnosed in women. A common treatment strategy for BC is still not available because of its molecular heterogeneity and resistance is developed in most of the patients through the course of treatment. Therefore, alternative medicine resources as being novel treatment options are needed to be used for the treatment of BC. Usnic Acid (UA) that is one of the secondary metabolites of lichens used for different purposes in the field of medicine and its anti-proliferative effect has been shown in certain cancer types, suggesting its potential use for the treatment. Methods: Anti-proliferative effect of UA in BC cells (MDA-MB-231, MCF-7, BT-474) was identified through MTT analysis. Microarray analysis was performed in cells treated with the effective concentration of UA and UA-responsive miRNAs were detected. Their targets and the pathways that they involve were determined using a miRNA target prediction tool. Results: Microarray experiments showed that 67 miRNAs were specifically responsive to UA in MDA-MB-231 cells while 15 and 8 were specific to BT-474 and MCF-7 cells, respectively. The miRNA targets were mostly found to play role in Hedgehog signaling pathway. TGF-Beta, MAPK and apoptosis pathways were also the prominent ones according to the miRNA enrichment analysis. Conclusion: The current study is important as being the first study in the literature which aimed to explore the UA related miRNAs, their targets and molecular pathways that may have roles in the BC. The results of pathway enrichment analysis and anti-proliferative effects of UA support the idea that UA might be used as a potential alternative therapeutic agent for BC treatment.

scholarly journals FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer

Cell Reports ◽  
2015 ◽  
Vol 13 (5) ◽  
pp. 1046-1058 ◽  
Author(s):  
Bingchen Han ◽  
Ying Qu ◽  
Yanli Jin ◽  
Yi Yu ◽  
Nan Deng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hedgehog Signaling ◽  
Basal Like Breast Cancer

Abstract P3-01-25: Hedgehog signaling-mediated adaptation to hypoxic microenvironment promotes osteoclastogenesis in advanced breast cancer

2020 ◽  
Author(s):  
Tshering Dolma Lama-Sherpa ◽  
Shamik Das ◽  
Ann Hanna ◽  
Sarah Kammerud ◽  
Lalita A Shevde
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Hedgehog Signaling ◽  
Advanced Breast

scholarly journals Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61

Oncogene ◽  
2011 ◽  
Vol 31 (28) ◽  
pp. 3370-3380 ◽  
Author(s):  
L G Harris ◽  
L K Pannell ◽  
S Singh ◽  
R S Samant ◽  
L A Shevde
Keyword(s):  
Breast Cancer ◽  
Hedgehog Signaling ◽  
Spontaneous Metastasis

scholarly journals Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer

2010 ◽  
Vol 102 (2) ◽  
pp. 373-381 ◽  
Author(s):  
Masae Souzaki ◽  
Makoto Kubo ◽  
Masaya Kai ◽  
Chizu Kameda ◽  
Haruo Tanaka ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathway ◽  
Invasive Breast Cancer ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway ◽  
Non Invasive
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