Disulfiram and its novel derivative sensitize prostate cancer cells to the growth regulatory mechanisms of the cell by re-expressing the epigenetically repressed tumor suppressor-estrogen receptor β

2015 ◽  
Vol 55 (11) ◽  
pp. 1843-1857 ◽  
Author(s):  
Vikas Sharma ◽  
Vikas Verma ◽  
Nand Lal ◽  
Santosh K. Yadav ◽  
Saumya Sarkar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Estrogen Receptor Β ◽  
Regulatory Mechanisms ◽  
Prostate Cancer Cells

Androgen receptor regulation by physiological concentration of the isoflavonoid genistein in LNCaP prostate cancer cells is mediated by estrogen receptor β

2003 ◽  
Vol 2 (6) ◽  
pp. 62
Author(s):  
Jasmin Bektic ◽  
Andreas P Berger ◽  
Karina Pfeil ◽  
Gabriele Dobler ◽  
Georg Bartsch ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Estrogen Receptor Β ◽  
Receptor Regulation ◽  
Prostate Cancer Cells ◽  
Physiological Concentration

Abstract 1715: Estrogen receptor β induces apoptosis through PUMA independent of p53 in prostate cancer cells.

2013 ◽  
Author(s):  
Prasenjit Dey ◽  
Jan-Ake Gustafsson ◽  
Anders M. Strom
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Estrogen Receptor Β ◽  
Prostate Cancer Cells

scholarly journals ICI 182,780-Regulated Gene Expression in DU145 Prostate Cancer Cells Is Mediated by Estrogen Receptor-β/NFκB Crosstalk

Neoplasia ◽  
2006 ◽  
Vol 8 (4) ◽  
pp. 242-249 ◽  
Author(s):  
Yuet-Kin Leung ◽  
Ying Gao ◽  
Kin-Mang Lau ◽  
Xiang Zhang ◽  
Shuk-Mei Ho
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Estrogen Receptor Β ◽  
Prostate Cancer Cells ◽  
Ici 182,780 ◽  
Regulated Gene Expression

Apigenin manipulates the ubiquitin–proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells

2014 ◽  
Vol 54 (8) ◽  
pp. 1255-1267 ◽  
Author(s):  
Vishal Singh ◽  
Vikas Sharma ◽  
Vikas Verma ◽  
Deepti Pandey ◽  
Santosh K. Yadav ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Ubiquitin Proteasome System ◽  
Estrogen Receptor Β ◽  
Prostate Cancer Cells ◽  
Ubiquitin Proteasome

Androgen receptor or estrogen receptor-β blockade alters DHEA-, DHT-, and E2-induced proliferation and PSA production in human prostate cancer cells

The Prostate ◽  
2007 ◽  
Vol 67 (11) ◽  
pp. 1152-1162 ◽  
Author(s):  
Julia T. Arnold ◽  
Xunxian Liu ◽  
Jeffrey D. Allen ◽  
Hanh Le ◽  
Kimberly K. McFann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Estrogen Receptor Β ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

The p202 Gene as a Tumor Suppressor in Prostate Cancer Cells

2003 ◽  
Author(s):  
Mien-Chie Hung
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Prostate Cancer Cells

scholarly journals Crosstalk between Prostate Cancer Cells and Tumor-Associated Fibroblasts Enhances the Malignancy by Inhibiting the Tumor Suppressor PLZF

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1083
Author(s):  
Kum Hee Noh ◽  
Ae Jin Jeong ◽  
Haeri Lee ◽  
Song-Hee Lee ◽  
Eunhee Yi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Cancer Metastasis ◽  
Tyrosine Phosphatase ◽  
Migration And Invasion ◽  
Metastatic Progression ◽  
Prostate Cancer Cells ◽  
Prostate Cancer Metastasis

Although prostate cancer is clinically manageable during the early stages of progression, metastatic progression severely compromises the prognosis and leads to mortality. Constitutive activation of STAT3 has been connected to prostate cancer malignancy, and abolishing the STAT3 activity may diminish tumor growth and metastasis. However, its suppressor genes and pathways have not been well established. In this study, we show that promyelocytic leukemia zinc finger (PLZF) has a putative tumor-suppressor function in prostate cancer by inhibiting phosphorylation of STAT3. Compared with a benign prostate, high-grade prostate cancer patient tissue was negatively correlated with PLZF expression. PLZF depletion accelerated proliferation and survival, migration, and invasion in human prostate cancer cells. Mechanistically, we demonstrated a novel role of PLZF as the transcriptional regulator of the tyrosine phosphatase SHP-1 that inhibits the oncogenic JAKs–STAT3 pathway. These results suggest that the collapse of PLZF expression by the CCL3 derived from fibroblasts accelerates the cell migration and invasion properties of prostate cancer cells. Our results suggest that increasing PLZF could be an attractive strategy for suppressing prostate cancer metastasis as well as for tumor growth.

The androgen receptor antagonist enzalutamide induces apoptosis, dysregulates the heat shock protein system, and diminishes the androgen receptor and estrogen receptor β1 expression in prostate cancer cells

2019 ◽  
Vol 120 (10) ◽  
pp. 16711-16722
Author(s):  
Alexander Abazid ◽  
Benedikt Martin ◽  
Anja Choinowski ◽  
Rhiannon V. McNeill ◽  
Lars‐Ove Brandenburg ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Androgen Receptor ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Receptor Antagonist ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Protein System ◽  
Androgen Receptor Antagonist
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