Focal adhesion kinase (FAK) inhibitor‐defactinib suppresses the malignant progression of human esophageal squamous cell carcinoma (ESCC) cells via effective blockade of PI3K/AKT axis and downstream molecular network

2020 ◽  
Author(s):  
Lingyuan Zhang ◽  
Di Zhao ◽  
Yan Wang ◽  
Weimin Zhang ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Squamous Cell ◽  
Malignant Progression ◽  
Molecular Network

Focal adhesion kinase overexpression: Correlation with lymph node metastasis and shorter survival in oral squamous cell carcinoma

Head & Neck ◽  
2012 ◽  
Vol 35 (6) ◽  
pp. 826-830 ◽  
Author(s):  
Juan Carlos de Vicente ◽  
Pablo Rosado ◽  
Paloma Lequerica-Fernández ◽  
Eva Allonca ◽  
Lucas Villallaín ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Squamous Cell ◽  
Node Metastasis

CCL18-induced HOTAIR upregulation promotes malignant progression in esophageal squamous cell carcinoma through the miR-130a-5p-ZEB1 axis

2019 ◽  
Vol 460 ◽  
pp. 18-28 ◽  
Author(s):  
Wenjian Wang ◽  
Duoguang Wu ◽  
Xiaotian He ◽  
Xueting Hu ◽  
Chuwen Hu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Progression

scholarly journals Unbalanced YAP–SOX9 circuit drives stemness and malignant progression in esophageal squamous cell carcinoma

Oncogene ◽  
2018 ◽  
Vol 38 (12) ◽  
pp. 2042-2055 ◽  
Author(s):  
Lianghai Wang ◽  
Zhiyu Zhang ◽  
Xiaodan Yu ◽  
Xuan Huang ◽  
Zheng Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Progression

scholarly journals The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells

2011 ◽  
Vol 131 (2) ◽  
pp. 287-297 ◽  
Author(s):  
Alan Serrels ◽  
Kenneth McLeod ◽  
Marta Canel ◽  
Andrew Kinnaird ◽  
Kathryn Graham ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Catalytic Activity ◽  
Cell Carcinoma ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals CircCNTNAP3-TP53-positive feedback loop suppresses malignant progression of esophageal squamous cell carcinoma

2020 ◽  
Vol 11 (11) ◽  
Author(s):  
Hui Wang ◽  
Xuming Song ◽  
Yajing Wang ◽  
Xuewen Yin ◽  
Yingkuan Liang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Malignant Progression ◽  
Gene Transcript ◽  
Wild Type ◽  
Positive Feedback Loop

AbstractMutation or downregulation of p53 (encoded by TP53) accelerates tumorigenesis and malignant progression in esophageal squamous cell carcinoma (ESCC). However, it is still unknown whether circular RNAs (circRNAs), a novel class of endogenous noncoding RNAs, participate in the regulation of this progress. In this study, we explored the expression profiles of circRNAs in three paired samples of ESCC and identified cCNTNAP3, which is a circRNA that originates from the CNTNAP3 gene transcript and is highly expressed in normal human esophageal tissue. However, we found that the cCNTNAP3 expression level was significantly downregulated in ESCC tissues. In vitro and in vivo studies revealed that cCNTNAP3 inhibited proliferation and increased apoptosis in p53 wild-type ESCC cells, but not in mutant cells. Mechanistically, we found that cCNTNAP3 promotes the expression of p53 by sponging miR-513a-5p. Rescue assay confirmed that the suppressive function of cCNTNAP3 was dependent on miR-513a-5p. We also observed that p53/RBM25 participated in the formation of cCNTNAP3, which implied the existence of a positive feedback loop between cCNTNAP3 and p53. Furthermore, the downregulation of cCNTNAP3 was significantly correlated with later T stage and thus can serve as an independent risk factor for the overall survival of patients with p53 wild-type ESCC. In conclusion, the cCNTNAP3-TP53 positive feedback loop may provide a potential target for the management of ESCC, which also reveals the important role of circRNAs in the regulation of p53.

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