Self‐Report versus Clinician Examination in Early Parkinson's Disease

Background: Cognitive impairment is common in Parkinson’s disease (PD) and highly associated with loss of independence, caregiver burden, and assisted living placement. The need for cognitive functional capacity tools validated for use in PD clinical and research applications has thus been emphasized in the literature. The Virtual Reality Functional Capacity Assessment Tool (VRFCAT-SL) is a tablet-based instrument that assesses proficiency for performing real world tasks in a highly realistic environment. Objective: The present study explored application of the VRFCAT-SL in clinical assessments of patients with PD. Specifically, we examined associations between VRFCAT-SL performance and measures of cognition, motor severity, and self-reported cognitive functioning. Methods: The VRFCAT-SL was completed by a sample of 29 PD patients seen in clinic for a comprehensive neuropsychological evaluation. Fifteen patients met Movement Disorders Society Task Force criteria for mild cognitive impairment (PD-MCI); no patients were diagnosed with dementia. Non-parametric correlations between VRFCAT-SL performance and standardized neuropsychological tests and clinical measures were examined. Results: VRFCAT-SL performance was moderately associated with global rank on neuropsychological testing and discriminated PD-MCI. Follow-up analyses found completion time was associated with visual memory, sustained attention, and set-switching, while errors were associated with psychomotor inhibition. No clinical or motor measures were associated with VRFCAT-SL performance. Self-report was not associated with VRFCAT-SL or neuropsychological test performance. Conclusion: The VRFCAT-SL appears to provide a useful measure of cognitive functional capacity that is not confounded by PD motor symptoms. Future studies will examine utility in PD dementia.

Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease

Movement Disorders ◽

10.1002/mds.28608 ◽

2021 ◽

Author(s):

Thomas Kremer ◽

Kirsten I. Taylor ◽

Juliane Siebourg‐Polster ◽

Thomas Gerken ◽

Andreas Staempfli ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cerebrospinal Fluid ◽

Longitudinal Analysis ◽

Early Parkinson’S Disease ◽

Neurotransmitter Metabolites

Nose swab could point to early Parkinson's disease

The New Scientist ◽

10.1016/s0262-4079(21)00859-9 ◽

2021 ◽

Vol 250 (3335) ◽

pp. 14

Author(s):

Clare Wilson

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Early Parkinson’S Disease

Medical follow up assessments of iPrognosis application users for early Parkinson's disease detection

Parkinsonism & Related Disorders ◽

10.1016/j.parkreldis.2020.06.155 ◽

2020 ◽

Vol 79 ◽

pp. e37

Author(s):

L. Klingelhoefer ◽

S. Bostanjopoulou ◽

D. Trivedi ◽

S. Hadjidimitriou ◽

D. Hausbrand ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Disease Detection ◽

Early Parkinson’S Disease

Value of combined midbrain sonography, olfactory and motor function assessment in the differential diagnosis of early Parkinson's disease

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp-2011-301719 ◽

2012 ◽

Vol 83 (4) ◽

pp. 441-447 ◽

Cited By ~ 55

Author(s):

Knut Busse ◽

Robert Heilmann ◽

Sabine Kleinschmidt ◽

Mazen Abu-Mugheisib ◽

Jacqueline Höppner ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Differential Diagnosis ◽

Motor Function ◽

Early Parkinson’S Disease ◽

Function Assessment