scholarly journals Magnetically focused 70 MeV proton minibeams for preclinical experiments combining a tandem accelerator and a 3 GHz linear post accelerator

2021 ◽  
Author(s):  
Michael Mayerhofer ◽  
Gerd Datzmann ◽  
Alberto Degiovanni ◽  
Veliko Dimov ◽  
Günther Dollinger
PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258477
Author(s):  
Michael Mayerhofer ◽  
Andreas Bergmaier ◽  
Gerd Datzmann ◽  
Hermann Hagn ◽  
Ricardo Helm ◽  
...  

To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (designs: AVO-ADAM S.A, Geneva, Switzerland and ENEA, Frascati, Italy). To enhance the transmission of the tandem beam through the post-accelerator by a factor of 3, two drift tube buncher units were designed and constructed: A brazed 5-gap structure (adapted SCDTL tank of the TOP-IMPLART project (ENEA)) and a non-brazed low budget 4-gap structure. Both are made of copper. The performance of the two differently manufactured units was evaluated using a 16 MeV tandem accelerator beam and a Q3D magnetic spectrograph. Both buncher units achieve the required summed voltage amplitude of 42 kV and amplitude stability at a power feed of less than 800 W.


Author(s):  
Muhammad Irfan ◽  
Safdar Abbas ◽  
Beenish Jehan Azhar ◽  
Shakeel Ahmad ◽  
Hafsa Muhammad ◽  
...  

Background: Phytonutrients in peach fruits have health promoting antioxidants against various chronic diseases. However, there is no extensive data to show the nutritional values of Local peach cultivars after post-harvest treatments. Objective: Mainly this study was objective to determine the effect of calcium carbide on nutritional value and quality of fruits of Pakistani peach cultivars. Methods: The peach fruits were collected from three different peach orchids of KPK and the fruits were divided into 4 groups while 5th group was collected from local fruit shop. Each experimental group was treated with different concentration of calcium carbide whereas control group was not treated. The peel and pulp samples were oven dried and ground to fine powder separately. The elemental compositions were determined using Particle Induced X-ray emission and Pelletron Tandem Accelerator. Result: Sixteen elements were identified in peach fruits and the elements were Al, P, S, Cl, K, Ca, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, and Se. In peel, concentration of some elements increased or decreased after treatment with CaC2 while in pulp the conc. of nearly all detected elements was increased in treated samples. We found significantly high amount of heavy metals traces including As, Se, Co, Si, and P in peach fruits treated with CaC2. Interestingly, the presence of trichomes in peach skin prevents the transfer of these heavy metals deep into the pulp which was also verified by the elemental profiling of nectarines. Conclusion: Conclusively, the artificial ripening with CaC2 changed the nutritional value of peach fruits that has higher health risks if consume with the peel. According to our best knowledge, this is the first report that highlights the effects of CaC2 which deteriorate the nutritional value of peach fruits in Pakistan.


Radiocarbon ◽  
2010 ◽  
Vol 52 (2) ◽  
pp. 263-271 ◽  
Author(s):  
P Naysmith ◽  
G T Cook ◽  
S P H T Freeman ◽  
E M Scott ◽  
R Anderson ◽  
...  

In 2003, a National Electrostatics Corporation (NEC) 5MV tandem accelerator mass spectrometer was installed at SUERC, providing the radiocarbon laboratory with 14C measurements to 4–5‰ repeatability. In 2007, a 250kV single-stage accelerator mass spectrometer (SSAMS) was added to provide additional 14C capability and is now the preferred system for 14C analysis. Changes to the technology and to our operations are evident in our copious quality assurance data: typically, we now use the 134-position MC-SNICS source, which is filled to capacity. Measurement of standards shows that spectrometer running without the complication of on-line δ13C evaluation is a good operational compromise. Currently, 3‰ 14C/13C measurements are routinely achieved for samples up to nearly 3 half-lives old by consistent sample preparation and an automated data acquisition algorithm with sample random access for measurement repeats. Background and known-age standard data are presented for the period 2003–2008 for the 5MV system and 2007–2008 for the SSAMS, to demonstrate the improvements in data quality.


1961 ◽  
Vol 32 (5) ◽  
pp. 568-571 ◽  
Author(s):  
P. H. Rose ◽  
A. B. Wittkower ◽  
R. P. Bastide ◽  
A. J. Gale

2014 ◽  
Vol 9 (12) ◽  
pp. P12016-P12016 ◽  
Author(s):  
D. Kasatov ◽  
A. Kuznetsov ◽  
A. Makarov ◽  
I. Shchudlo ◽  
I. Sorokin ◽  
...  

1988 ◽  
Vol 100 ◽  
Author(s):  
J. Koike ◽  
P. R. Okamoto ◽  
M. Meshii

ABSTRACTCuTi was irradiated with 1MeV Ne+ and Kr+ at various temperatures in the Argonne-HVEM interfaced to a tandem accelerator. The integrated intensity of diffuse ring was measured by a microdensitometer and analyzed by Gibbons model for the dose dependence of the amorphous volume. The results indicate that the direct amorphization occurs in a single damage zone with Kr+, but the overlapping of three damage zones is necessary with Ne+. The critical temperature for amorphization was 401±22K for Ne+ and 543±20K for Kr+, respectively. With Kr+, the critical temperature was nearly equal to the thermal crystallization temperature of an amorphous zone embedded in the crystalline matrix. Using the present observations, the relation between the amorphization process and the critical temperature is discussed.


Author(s):  
M. Schiffer ◽  
A. Dewald ◽  
C. Feuerstein ◽  
R. Altenkirch ◽  
A. Stolz ◽  
...  
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