scholarly journals Mental retardation genes in drosophila: New approaches to understanding and treating developmental brain disorders

2005 ◽  
Vol 11 (4) ◽  
pp. 286-294 ◽  
Author(s):  
Linda L. Restifo
PEDIATRICS ◽  
1985 ◽  
Vol 76 (3) ◽  
pp. 457-458 ◽  
Author(s):  

Neurologic and communicative disorders affect 42 million Americans. Mental retardation is present in 780,000 school-age children, cerebral palsy affects 750,000 Americans, and nearly 2 million individuals have epilepsy. Among these 42 million are countless individuals who suffer combinations of these neurologic disabilities. In an effort to define our current state of knowledge about the prenatal and perinatal factors associated with brain disordens, the National Institute of Neurologic and Communicative Disorders and Stroke (NINCDS) and the National Institute of Child Health and Human Development (NICHHD) appointed a group of experts to survey current data in order to identify pregnancy- and birth-related events that may account for the continued incidence of neurologic handicap among infants and children. Their results were published in a report entitled Prenatal and Perinatal Factors Associated with Brain Disorders. Despite rapid advances in obstetric and neonatal medicine during the past several decades, physicians, patients, and attorneys still believe that the major causes of brain disorders are related to birth trauma and problems of labor. The Committee found that, although it was once simple to say that a specific event such as birth trauma or asphyxia caused brain disorders, it is not usually possible to pinpoint a single cause and its effect. The normal brain's ability to repair or compensate for even major developmental disruptions, combined with the gross and subtle interactions of biologic, social and environmental factors, confounds the task of assigning etiologies to brain disorders. The causes of severe mental retardation are primarily genetic, biochemical, viral, and developmental and not related to birth events.


2019 ◽  
Vol 42 ◽  
Author(s):  
John P. A. Ioannidis

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.


2019 ◽  
Vol 42 ◽  
Author(s):  
Karen Bartsch ◽  
David Estes

Abstract In challenging the assumption of autistic social uninterest, Jaswal & Akhtar have opened the door to scrutinizing similar unexamined assumptions embedded in other literatures, such as those on children's typically developing behaviors regarding others’ minds and morals. Extending skeptical analysis to other areas may reveal new approaches for evaluating competing claims regarding social interest in autistic individuals.


Author(s):  
Line Buhl ◽  
David Muirhead

There are four lysosomal diseases of which the neuronal ceroid lipofuscinosis is the rarest. The clinical presentation and their characteric abnormal ultrastructure subdivide them into four types. These are known as the Infantile form (Santavuori-Haltia), Late infantile form (Jansky-Bielschowsky), Juvenile form (Batten-Spielmeyer-Voght) and the Adult form (Kuph's).An 8 year old Omani girl presented wth myclonic jerks since the age of 4 years, with progressive encephalopathy, mental retardation, ataxia and loss of vision. An ophthalmoscopy was performed followed by rectal suction biopsies (fig. 1). A previous sibling had died of an undiagnosed neurological disorder with a similar clinical picture.


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