scholarly journals Prenatal exposure to persistent organic pollutants and rapid weight gain and overweight in infancy

Obesity ◽  
2013 ◽  
Vol 22 (2) ◽  
pp. 488-496 ◽  
Author(s):  
Damaskini Valvi ◽  
Michelle Ann Mendez ◽  
Raquel Garcia-Esteban ◽  
Ferran Ballester ◽  
Jesús Ibarluzea ◽  
...  
2021 ◽  
Vol 151 ◽  
pp. 106469
Author(s):  
Nuria Güil-Oumrait ◽  
Damaskini Valvi ◽  
Raquel Garcia-Esteban ◽  
Monica Guxens ◽  
Jordi Sunyer ◽  
...  

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Marlene Cervantes González

Abstract Persistent Organic Pollutants (POPs) are exogenous, artificially made chemicals that can disrupt the biological system of individuals and animals. POPs encompass a variety of chemicals including, dioxins, organochlorines (OCs), polychlorinated biphenyl (PCBs), and perfluoroalkyl substances (PFASs) that contain a long half-life and highly resistant to biodegradation. These environmental pollutants accumulate over time in adipose tissues of living organisms and alter various insulin function-related genes. Childhood Metabolic Syndrome (MetS) consists of multiple cardiovascular risk factors, insulin function being one of them. Over the years, the incidence of the syndrome has increased dramatically. It is imperative to explore the role of persistent organic pollutants in the development of Childhood Metabolic Syndrome. Some epidemiological studies have reported an association between prenatal exposure to POPs and offspring MetS development throughout childhood. These findings have been replicated in animal studies in which these pollutants exercise negative health outcomes such as obesity and increased waist circumference. This review discusses the role of prenatal exposure to POPs among offspring who develop MetS in childhood, the latest research on the MetS concept, epidemiological and experimental findings on MetS, and the POPs modes of action. This literature review identified consistent research results on this topic. Even though the studies in this review had many strengths, one major weakness was the usage of different combinations of MetS criteria to measure the outcomes. These findings elucidate the urgent need to solidify the pediatric MetS definition. An accurate definition will permit scientists to measure the MetS as a health outcome properly and allow clinicians to diagnose pediatric MetS and provide individualized treatment appropriately.


2015 ◽  
Vol 123 (10) ◽  
pp. 1015-1021 ◽  
Author(s):  
Marina Vafeiadi ◽  
Vaggelis Georgiou ◽  
Georgia Chalkiadaki ◽  
Panu Rantakokko ◽  
Hannu Kiviranta ◽  
...  

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Hilde B. Lauritzen ◽  
Tricia L. Larose ◽  
Torbjørn Øien ◽  
Torkjel M. Sandanger ◽  
Jon Ø. Odland ◽  
...  

2018 ◽  
Vol 119 ◽  
pp. 398-406 ◽  
Author(s):  
Sujin Kim ◽  
Yoon Hee Cho ◽  
Inae Lee ◽  
Wonji Kim ◽  
Sungho Won ◽  
...  

2018 ◽  
Vol 121 ◽  
pp. 13-22 ◽  
Author(s):  
Sietske A. Berghuis ◽  
Koenraad N.J.A. Van Braeckel ◽  
Pieter J.J. Sauer ◽  
Arend F. Bos

Author(s):  
Anna A. Krönke ◽  
Anne Jurkutat ◽  
Maike Schlingmann ◽  
Tanja Poulain ◽  
Matthias Nüchter ◽  
...  

Abstract Background Potentially harmful effects of persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (DDT) on prenatal development and the endocrine system have been controversially discussed. Methods Working with a German cohort of 324 pregnant women, we assessed POP levels and used robust linear regression models to determine potential associations between maternal POP concentrations and pre- and postnatal development in the children, as well as the thyroid hormone status of the mother and child. Results Maternal p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) and most measured PCBs positively correlated with postnatal weight gain. We detected no correlation between newborn birth weight and head circumference, respectively, and maternal PCB and p,p′-DDE serum levels, while body length at birth was negatively associated with the maternal serum concentration of PCB 183. Maternal p,p′-DDE and nearly all PCB serum levels showed a negative correlation with maternal free triiodothyronine (FT3). p,p′-DDE and PCB 74 and 118 were negatively associated with maternal thyroid-stimulating hormone levels. In addition, we identified significant associations between maternal POP levels and thyroid hormone parameters of the child. Conclusions These results indicate that POP exposure likely affects different aspects of pre- and postnatal development and impacts the thyroid hormone status of both mother and child. Impact Pregnant women in a German cohort display a substantial accumulation of POPs. Body mass index and age influence maternal serum POP levels. Maternal POP levels show correlations with the child’s length at birth and weight gain, and FT3 levels in the mother and child. Our data provide additional evidence for the potentially harmful influence of POPs. Our data indicate that POPs influence pre- and postnatal development.


2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Aimin Chen ◽  
Changchun Xie ◽  
Roman Jandarov ◽  
Ann Vuong ◽  
Kim Dietrich ◽  
...  

2014 ◽  
Vol 133 ◽  
pp. 211-219 ◽  
Author(s):  
Martin S. Forde ◽  
Eric Dewailly ◽  
Lyndon Robertson ◽  
Elhadji A. Laouan Sidi ◽  
Suzanne Côté ◽  
...  

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